Stereospecificity of SP1 and SP2 substance P receptors.

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:The aim of the present work was to study whether physiological doses of melatonin (1nM) modified DNA synthesis in MCF-7 human breast cancer cells. Exponentially growing MCF-7 cells were incubated for 24 h with thymidine (2mM) for blocking mitosis and synchronizing the cell division cycle. Synchronization was assessed ...

journal_title：Life sciences

authors： Cos S,Fernández F,Sánchez-Barceló EJ

更新日期：1996-05-24 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：AIMS:Ischemia/reperfusion injury (IRI), resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether a HIF-1α inhibitor or various antioxidants were able to prevent ischemic injury in a cellular model in which experimental hypoxia was induc...

journal_title：Life sciences

authors： Song H,Han IY,Kim Y,Kim YH,Choi IW,Seo SK,Jung SY,Park S,Kang MS

更新日期：2015-04-01 00:00:00

abstract：:The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The ene...

journal_title：Life sciences

authors： Ozawa K,Fujimoto T,Nakatani T,Asano M,Aoyama H,Tobe T

更新日期：1982-08-16 00:00:00

abstract：:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...

journal_title：Life sciences

authors： Brown-Croyts LM,Caton PW,Radecki DT,McPherson SL

更新日期：2000-06-30 00:00:00

abstract：AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...

journal_title：Life sciences

authors： Li Z,Zhang X,Jin T,Hao J

更新日期：2020-02-15 00:00:00

abstract：:The aim of this study was to verify, by means of functional methods, whether the circadian rhythm changes adrenergic response patterns in the epididymal half of the vas deferens isolated from control rats as well as from rats submitted to acute stress. The experiments were performed at 9:00 a.m., 3:00 p.m., 9:00 p.m.,...

journal_title：Life sciences

authors： Leite-Kassuya CA,Pereira OC

更新日期：2005-08-26 00:00:00

abstract：:The best conditions for extractions of free pyrroloquinoline quinone (PQQ) from crude biological samples were investigated with various organic solvents and Sep-Pak C18 cartridges. PQQ was measured with use of its native fluorescence in aqueous solution. PQQ was well extracted into n-butanol under acid conditions, and...

journal_title：Life sciences

authors： Suzuki O,Kumazawa T,Seno H,Urakami T,Matsumoto T

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:We aimed to explore the expression level and biological function of miR-145-5p in preeclampsia (PE). METHODS:The differentially expressed miRNA/mRNA between normal placentas and PE placentas were screened using the GSE84260 and GSE73374 datasets from the Gene Expression Omnibus Database. The expression of mi...

journal_title：Life sciences

authors： Lv Y,Lu X,Li C,Fan Y,Ji X,Long W,Meng L,Wu L,Wang L,Lv M,Ding H

更新日期：2019-12-15 00:00:00

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...

journal_title：Life sciences

authors： Verona J,Gilligan LE,Giménez C,Verona MF,Lombardo SM,Baenz A,Divita V,González CD,Gómez Rosso L,Brites F

更新日期：2013-07-30 00:00:00

abstract：:Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...

journal_title：Life sciences

authors： Oyanagui Y,Sato S

更新日期：1993-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play important roles in fatty acid metabolism. The present study examined the regulation of retinoic acid receptor (RAR alpha, beta, and gamma), RXR (alpha, beta, and gamma), PPAR, cytochrome P450 2E1 (CYP2E1), catalase, and beta-actin gen...

journal_title：Life sciences

authors： Wan YJ,Morimoto M,Thurman RG,Bojes HK,French SW

更新日期：1995-01-01 00:00:00

abstract：AIMS:The hypoxia-stimulated response of the endocrine system depends on the kind and duration of hypoxia. Hypoxia has been reported to stimulate testosterone (T) production in rats, but the mechanisms remain to be investigated. MATERIALS AND METHODS:Male rats were divided into two groups. The rats exposed to chronic i...

journal_title：Life sciences

authors： Cho YM,Chou JC,Fang CM,Hu S,Wang KL,Wang SW,Wang PS

更新日期：2019-09-15 00:00:00

abstract：:In order to assess the relative cytokine contribution to endotoxin stimulation of pituitary-adrenocortical hormone secretion, we measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF alpha), adrenocorticotropin (ACTH) and corticosterone following lipopolysaccharide (LPS) challenge in rats....

journal_title：Life sciences

authors： Takao T,Nanamiya W,Takemura T,Nishiyama M,Asaba K,Makino S,Hashimoto K,De Souza EB

更新日期：1997-01-01 00:00:00

abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...

journal_title：Life sciences

authors： Pan H,Zhao F,Yang Y,Chang N

更新日期：2020-08-01 00:00:00

abstract：:The activity in cerebrospinal fluid (CSF) of dynorphin-converting enzyme (DCE) has been studied after voluntary exercise in the spontaneously hypertensive (SH) rat. The exercise consisted of spontaneous running in wheels for 4-5 weeks and the average running distance during the last two weeks was 4.0 km/24h. CSF sampl...

journal_title：Life sciences

authors： Persson S,Jónsdóttir I,Thorén P,Post C,Nyberg F,Hoffmann P

更新日期：1993-01-01 00:00:00

abstract：:Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...

journal_title：Life sciences

authors： Qian Y,Bourreau JP

更新日期：1999-01-01 00:00:00

abstract：:In the early 1970's, some papers appeared reporting an immune response to opiates in animals treated with morphine and in heroin addicts, but further researches failed to confirm these results in humans. The aim of the present work is investigating with a newly developed enzyme immunoassay the existence of specific an...

journal_title：Life sciences

authors： Gamaleya N,Tagliaro F,Parshin A,Vrublevskii A,Bugari G,Dorizzi R,Ghielmi S,Marigo M

更新日期：1993-01-01 00:00:00

abstract：:Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...

journal_title：Life sciences

authors： Colquhoun EQ,Eldershaw TP,Bennett KL,Hall JL,Dora KA,Clark MG

更新日期：1995-01-01 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：:We have proposed that the atypical opioid system in the mouse may be representative of that in the anorexia nervosa patient and may account for a biological predisposition to the disorder. This is in the context of our auto-addiction model of anorexia nervosa in which endogenous opioids play a critical role in its eti...

journal_title：Life sciences

authors： Marrazzi MA,Mullings-Britton J,Stack L,Powers RJ,Lawhorn J,Graham V,Eccles T,Gunter S

更新日期：1990-01-01 00:00:00

abstract：:This study assessed the effects of acute intravenous L-tryptophan (neutral amino acid precursor for serotonin) administration on cocaine-induced dopaminergic responses. Male Sprague-Dawley rats were surgically implanted with guide cannulas in the nucleus accumbens 5 days prior to the study and with vascular catheters ...

journal_title：Life sciences

authors： Molina PE,Ahmed N,Gatley J,Volkow ND,Abumrad NN

更新日期：2001-09-07 00:00:00

abstract：:Individuals have an inherent capacity to cope with stressors in the form of stress adaptation. Apart from stress adaptation there is another well documented phenomenon known as cross stress adaptation. In this, there is a reduction in stress responsiveness to a novel stressor (in which the adapted organism had never e...

journal_title：Life sciences

authors： Chauhan E,Bali A,Singh N,Jaggi AS

更新日期：2015-09-15 00:00:00

abstract：:Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...

journal_title：Life sciences

authors： Kumar A,Upadhyay G,Modi DR,Singh MP

更新日期：2007-11-30 00:00:00

abstract：:Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...

journal_title：Life sciences

authors： Piercey MF,Ray CA

更新日期：1988-01-01 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：:Skeletal muscle viability is crucially dependent on the tissue levels of its high energy phosphates. In this study we investigated the effect of the preservation medium Perfadex and illumination with Singlet Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by energy transfer from an excited photosen...

journal_title：Life sciences

authors： Lindgård A,Lundberg J,Rakotonirainy O,Elander A,Soussi B

更新日期：2003-04-25 00:00:00

abstract：:Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ...

journal_title：Life sciences

authors： Fujita K,Matsumura Y,Kita S,Hisaki K,Takaoka M,Morimoto S

更新日期：1994-01-01 00:00:00