Physical activity and cardiometabolic risk in male children and adolescents: the Balcarce study.

abstract：:The opiate antagonist naloxone was found to block nitrous oxide analgesia in a stereospecific fashion. Using a modified hotplate test in mice, the (-)-enantiomer of naloxone (which has a KD of approximately 1 nM for opiate receptors) antagonized the analgesic actions of nitrous oxide in a dose-dependent (2.5-20 mg/kg)...

journal_title：Life sciences

authors： Moody EJ,Mattson M,Newman AH,Rice KC,Skolnick P

更新日期：1989-01-01 00:00:00

abstract：:We studied the effect of thapsigargin on intracellular calcium levels ([Ca2+]i) measured by fura-2 fluorimetry in Madin Darby canine kidney (MDCK) cells. Thapsigargin elevated [Ca2+]i dose dependently with an EC50 of approximately 0.15 microM. The Ca2+ signal consisted of a slow rise, a gradual decay and a plateau. De...

journal_title：Life sciences

authors： Jan CR,Ho CM,Wu SN,Tseng CJ

更新日期：1999-01-01 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：:The effects of caffeine (Cf), theophylline (Tph) and theobromine (Tb) on the adrenal cortex were studied. No direct effect (hypophysectomized: hypo(-) rats) was observed with any of the three methyl-xanthines (MX) after chronic oral administration (5 days). An indirect effect (via the hypothalamo-hypophyseal-adrenal a...

journal_title：Life sciences

authors： Okyayuz GI,Ventura MA,Gardey C,Rey E,Thiroux G

更新日期：1985-09-30 00:00:00

abstract：:Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and syn...

journal_title：Life sciences

authors： Mei L,Si J

更新日期：1995-01-01 00:00:00

abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...

journal_title：Life sciences

authors： Kumar R,Yadav A,Pakrasi PL

更新日期：2017-02-01 00:00:00

abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...

journal_title：Life sciences

authors： Shukla GS,Hussain T,Chandra SV

更新日期：1987-11-09 00:00:00

abstract：AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

journal_title：Life sciences

authors： Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

更新日期：2020-06-01 00:00:00

abstract：AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...

journal_title：Life sciences

authors： Lin Z,Dodd CA,Filipov NM

更新日期：2013-01-17 00:00:00

abstract：:The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex. The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin. The membrane bound and soluble mitochondr...

journal_title：Life sciences

authors： Parola AL,Laird HE 2nd

更新日期：1991-01-01 00:00:00

abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...

journal_title：Life sciences

authors： Niisato N,Nishio K,Marunaka Y

更新日期：2002-07-26 00:00:00

abstract：:Several cryopreservation methods for precision-cut rat liver slices (PCLS) have been proposed, allowing a short-term (a few hours) maintainance of viability and functionality upon thawing. The aim of the present study was to test the metabolic capacity of PCLS cryopreserved by an ultrarapid method. The biotransformati...

journal_title：Life sciences

authors： Vanhulle VP,Martiat GA,Verbeeck RK,Horsmans Y,Calderon PB,Eeckhoudt SL,Taper HS,Delzenne N

更新日期：2001-04-13 00:00:00

abstract：:To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a holding potential of ...

journal_title：Life sciences

authors： Ma B,Yu LH,Fan J,Ni X,Burnstock G

更新日期：2008-08-01 00:00:00

abstract：:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...

journal_title：Life sciences

authors： Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna I

更新日期：1996-01-01 00:00:00

abstract：:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine....

journal_title：Life sciences

authors： Winfree CJ,Coombs DW,DeLeo JA,Colburn RW

更新日期：1992-01-01 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...

journal_title：Life sciences

authors： Henriksen SJ,Chouvet G,Bloom FE

更新日期：1982-10-18 00:00:00

abstract：:Mucosal mast cells are implicated in visceral hypersensitivity associated with irritable bowel syndrome (IBS). In this study, we investigated the role of mast cells in the development of visceral hypersensitivity by using mast cell deficient (Ws/Ws) rats and their control (W+/W+). In W+/W+ rats, an injection of 2,4,6-...

journal_title：Life sciences

authors： Ohashi K,Sato Y,Kawai M,Kurebayashi Y

更新日期：2008-02-13 00:00:00

abstract：AIMS:Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibito...

journal_title：Life sciences

authors： Bai XM,Jiang H,Ding JX,Peng T,Ma J,Wang YH,Zhang L,Zhang H,Leng J

更新日期：2010-01-30 00:00:00

abstract：AIMS:We explored the effect of aerobic exercise on renal sinus adipose (RSA) accumulation and RSA accumulation-related renal injury in obese mice. MAIN METHODS:C57BL/6J male mice (n = 30) were evenly divided into three groups: control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and obese + aerob...

journal_title：Life sciences

authors： Wang SS,Gu Q,Liu N,Li J,Liu X

更新日期：2021-01-23 00:00:00

abstract：:The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...

journal_title：Life sciences

authors： Tebano MT,Marinelli S,Sagratella S

更新日期：1997-01-01 00:00:00

abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...

journal_title：Life sciences

authors： Guimarães AG,Scotti L,Scotti MT,Mendonça Júnior FJ,Melo NS,Alves RS,De Lucca Júnior W,Bezerra DP,Gelain DP,Quintans Júnior LJ

更新日期：2014-10-22 00:00:00

abstract：:Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

journal_title：Life sciences

authors： Holtzman SG

更新日期：1987-01-26 00:00:00

abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

journal_title：Life sciences

authors： Yasmineh WG,Tsai MY,Theologides A

更新日期：1995-01-01 00:00:00

abstract：:We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...

journal_title：Life sciences

authors： Nanji AA,Sadrzadeh SM

更新日期：1994-01-01 00:00:00

abstract：:Synthetic atriopeptin II (APII) was infused directly into the right renal artery of intact conscious SHR at rates of 0.25-1 microgram/kg/min, while simultaneously measuring blood pressure (MAP) and selected regional blood flows. The latter were measured using chronically implanted miniaturized Doppler flowprobes that ...

journal_title：Life sciences

authors： Smits JF,van Essen H,Struyker-Boudier HA,Lappe RW

更新日期：1986-01-06 00:00:00

abstract：:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one su...

journal_title：Life sciences

authors： Elliott SN,McKnight W,Davies NM,MacNaughton WK,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

journal_title：Life sciences

authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

更新日期：2015-10-01 00:00:00

abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

journal_title：Life sciences

authors： Dufy B,Barker JL

更新日期：1982-05-31 00:00:00

abstract：AIMS:We herein investigated the inducibility of cytochrome P450 1A1 (CYP1A1) by Δ(9)-tetrahydrocannabinol, cannabidiol (CBD), and cannabinol, three major phytocannabinoids, using human hepatoma HepG2 cells. MAIN METHODS:The expression of CYP1A1 and the aryl hydrocarbon receptor (AhR) was measured by a quantitative rea...

journal_title：Life sciences

authors： Yamaori S,Kinugasa Y,Jiang R,Takeda S,Yamamoto I,Watanabe K

更新日期：2015-09-01 00:00:00