Abstract:
:This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response (p less than 0.01) at 15 min after drug administration. Administration of the dopaminergic agonist, bromocriptine, 2.5 mg tid for 4 days eliminated hPP responses to isometric handgrip exercise in these 11 volunteers. These results suggest that dopaminergic mechanisms may exert a tonic inhibitory effect on hPP secretion in normal subjects.
journal_name
Life Scijournal_title
Life sciencesauthors
Sowers JR,Stern N,Taylor ILdoi
10.1016/0024-3205(82)90063-7subject
Has Abstractpub_date
1982-12-27 00:00:00pages
2971-5issue
26eissn
0024-3205issn
1879-0631pii
0024-3205(82)90063-7journal_volume
31pub_type
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