Abstract：
:The neurological mutant whirler mouse, one of several strains of waltzing mice, may be suitable as an animal model for testing studies relative to hyperkinesis. As in hyperkinetic children, behaviorally the mice are extremely restless, nervous, excitable, irritable and aggressive but also show symptoms of rotation behavior, head-shaking and deafness. This study demonstrated that paradoxically oral intubation of daily doses of 5.0 mg/kg of methylphenidate during a 23 week period significantly decreased circling activity in test mice. The effects on circling behavior were reversible following cessation of methylphenidate administration. After 18 weeks of cessation of the CNS stimulant, oral administration of a single dose of 2.5 mg/kg of methylphenidate caused a 37.8% increase in circling activity but the increase compared to control whirler mice was not significant. Use of this strain as an animal model may be especially beneficial in the screening of new drugs for the treatment of hyperkinesis.
journal_name
Life Scijournal_title
Life sciencesauthors
Sackler AM,Weltman ASdoi
10.1016/0024-3205(85)90404-7subject
Has Abstractpub_date
1985-08-05 00:00:00pages
425-31issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(85)90404-7journal_volume
37pub_type
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