Effect of lithium on norepinephrine metabolic pathways.

Abstract:

:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC method with electrochemical detection for amines. The results obtained with a group of rats treated by lithium chloride (2 mmol/kg/IP) were compared with a control group receiving sodium chloride (2 mmol/kg/IP). Animals were killed at different times over a period of six hours in the morning following salt administration to minimize possible chronobiological effects. There are two pathways leading to MHPG formation: way A, without DHPG, and way B, with DHPG. In plasma and cerebral cortex of lithium treated rats, way A catabolism seems to be preferential. Lithium increases Mg(2+) and K(+) plasma levels. These results suggest that lithium may increase inactivation of NE and decrease NE available for adrenergic receptors.

journal_name

Life Sci

journal_title

Life sciences

authors

Sastre E,Nicolay A,Bruguerolle B,Portugal H

doi

10.1016/j.lfs.2004.12.033

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

758-67

issue

7

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(05)00251-1

journal_volume

77

pub_type

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