Abstract：
:Despite the fact that numerous studies have been published regarding the possible presence in plasma of an endogenous Na-K pump inhibitor with a digitalis-like structure in essential hypertension, very little is known about this factor in heart disease in general, and in situations characterized by low cardiac output. We measured the ability of plasma obtained from the femoral vein to inhibit a human renal Na(+)-K+ ATPase before and immediately after percutaneous transluminal coronary angioplasty (PTCA) in 6 patients suffering from angina pectoris and severe coronary stenosis. Intraerythrocyte sodium and potassium concentrations were also measured simultaneously. Na(+)-K+ ATPase inhibition proved significantly greater after angioplasty as compared to basal activity (percentage inhibition: 31.5 +/- 7.8 vs 16.1 +/- 12.2). No significant changes in intraerythrocyte sodium and potassium were detected. Though we are not in a position to define the mechanism underlying the increase in the digitalis-like factor, a plausible hypothesis may be that the reduction in cardiac output during PTCA by raising cardiac pressures may stimulate the production of a factor of compensatory inotropic significance.
journal_name
Life Scijournal_title
Life sciencesauthors
Delva P,Barbieri E,Devynck MA,Capra C,Pernollet MA,Meyer P,Destro G,Zardini P,Lechi Adoi
10.1016/0024-3205(90)90295-3subject
Has Abstractpub_date
1990-01-01 00:00:00pages
385-9issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(90)90295-3journal_volume
47pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90060-8
更新日期：1985-01-21 00:00:00
abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(92)90201-y
更新日期：1992-01-01 00:00:00
abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00551-7
更新日期：1999-01-01 00:00:00
abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117555
更新日期：2020-08-01 00:00:00
abstract：:Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00152-6
更新日期：1999-01-01 00:00:00
abstract：AIMS:Smokers have lower plasma concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) compared with nonsmokers. To determine the molecular basis of this observation, the effect of activation of the aryl hydrocarbon receptor (AhR) on apo A-I gene expression was examined. MAIN METH...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.06.002
更新日期：2012-07-26 00:00:00
abstract：AIMS:Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and red...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.022
更新日期：2018-08-15 00:00:00
abstract：:Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft. Another mechanism by which ACh levels can be increased is blockade of presynaptic M2 muscarinic autoreceptors that regulate ACh release. An antagonist designed fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01056-6
更新日期：2001-04-27 00:00:00
abstract：:We investigated serum levels of type III procollagen aminopeptide (CIII), 7S type IV collagen (CIV), and tissue inhibitor of metalloproteinase (TIMP) in 33 patients with type II diabetes mellitus (DM) without uremia (serum creatinine less than 1.5 mg/dl). The patients were divided into three groups based on measuremen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00099-9
更新日期：1996-01-01 00:00:00
abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00586-5
更新日期：2000-05-19 00:00:00
abstract：:Investigated in this study are the effects and mechanisms of exercise and chlorpromazine (CPZ), a widely used conventional antipsychotic drug, on the hepatic insulin sensitivity of 90% pancreatectomized (Px) male Sprague-Dawley rats. The Px diabetic rats were provided with 0, 5, or 50 mg CPZ per kg of body weight (No-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.04.001
更新日期：2007-06-06 00:00:00
abstract：:Recent findings indicate that low concentrations of dopamine (DA) stimulate the secretion of prolactin (PRL) in vitro. In this study, we found that low concentrations of the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY) stimulate PRL secretion in female rats, assessed by reverse hemolytic plaqu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90749-s
更新日期：1993-01-01 00:00:00
abstract：:The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90549-7
更新日期：1990-01-01 00:00:00
abstract：:The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90170-v
更新日期：1990-01-01 00:00:00
abstract：:Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(96)00502-4
更新日期：1997-01-01 00:00:00
abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00024-0
更新日期：1996-01-01 00:00:00
abstract：:Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90530-3
更新日期：1987-11-02 00:00:00
abstract：:It has been shown that lesions of the medial preoptic/suprachiasmatic nuclei (MPO/SCN) abolish the estrogen-induced afternoon prolactin (PRL) surge. Recent studies using both dopamine antagonist and thyrotropin-releasing hormone (TRH) successfully induced an increase in plasma PRL in various animal models. The same dr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(88)80011-0
更新日期：1988-01-01 00:00:00
abstract：AIMS:Carbon nanotube (CNT) membranes offer an exciting opportunity to mimic natural protein channels due to 1) a mechanism of dramatically enhanced fluid flow 2) ability to place 'gatekeeper' chemistry at the entrance to pores 3) the ability for biochemical reactions to occur on gatekeeper molecules and 4) an ability t...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2009.04.006
更新日期：2010-04-10 00:00:00
abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117368
更新日期：2020-03-15 00:00:00
abstract：:To study the role of IL-5 in allergic airway hyperreactivity, the time course for the production of cytokines, the infiltration of inflammatory cells and the onset of airway hyperreactivity after three inhalations of antigens were studied in mice. The effect of the soluble alpha-chain of murine recombinant interleukin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90139-2
更新日期：1994-01-01 00:00:00
abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117429
更新日期：2020-04-15 00:00:00
abstract：:We had previously hypothesized that linoleic acid (LA) was essential for development of alcoholic induced liver injury in our rat model. Male Wistar rats were fed a nutritionally adequate diet (25% calories as fat) with ethanol (8-17 g/kg/day). The source of fat was tallow (0.7% LA), lard (2.5% LA) or tallow supplemen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90599-7
更新日期：1989-01-01 00:00:00
abstract：AIMS:Histone modifications play central epigenetic roles in regulating the entire genome of the cell and cell proliferation. Herein, we investigated the effects of the natural compound, 16-hydroxycleroda-3,13-dien-15,16-olide (PL3), on the expressions of histone-modifying enzymes, and examined how it induces apoptosis ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.09.011
更新日期：2011-12-05 00:00:00
abstract：:Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90219-h
更新日期：1990-01-01 00:00:00
abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118833
更新日期：2021-01-15 00:00:00
abstract：:Glutathione homeostasis was investigated in unilaterally nephrectomized and sham-operated rats. Following twelve days of compensatory renal growth, it was found that the concentrations of glutathione and glutathione disulfide in representative samples of the entire remnant right kidney from the nephrectomized rats wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90132-4
更新日期：1988-01-01 00:00:00
abstract：:The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.005
更新日期：2006-04-18 00:00:00
abstract：:Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02085-w
更新日期：1995-01-01 00:00:00
abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00770-4
更新日期：1997-01-01 00:00:00
