Abstract:
:The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4% at 1 microgram/kg) and the superior mesenteric artery (49.0 +/- 16.8% at 1 microgram/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4 +/- 1.2% at 1 microgram/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.
journal_name
Life Scijournal_title
Life sciencesauthors
Sumi S,Inoue K,Hosotani R,Kogire M,Doi R,Yun M,Higashide S,Minote H,Takaori K,Kaji Hdoi
10.1016/0024-3205(90)90170-vsubject
Has Abstract,Author List Incompletepub_date
1990-01-01 00:00:00pages
1115-9issue
13eissn
0024-3205issn
1879-0631pii
0024-3205(90)90170-Vjournal_volume
47pub_type
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