Abstract:
:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one such drug, alendronate, to damage the gastric mucosa and to influence the severity and healing of gastric ulcers in rodents. The effects of alendronate on indomethacin-induced antral ulceration was evaluated in the rabbit, while effects on ulcer healing and on the formation of gastric erosions was evaluated in the rat. Effects of alendronate on gastric acid secretion, blood flow and prostaglandin synthesis were also evaluated. Alendronate caused erosions in the rabbit stomach, but not antral ulceration. However, at the highest doses tested (80 mg) alendronate increased the incidence and size of indomethacin-induced antral ulcers. Alendronate also enhanced indomethacin-induced gastric damage in the rat, and delayed gastric ulcer healing. These effects of alendronate were not attributable to changes in gastric acid secretion, blood flow, prostaglandin synthesis or the pharmacokinetics of indomethacin. The damaging effects of alendronate on the stomach were due to topical irritant effects and could be observed at concentrations as low as 4 mg/ml within 30 min of oral administration or topical superfusion. These results support preliminary clinical evidence that alendronate can damage the gastric mucosa. While gastric injury may be a rare occurrence in patients taking this drug, concomitant use of alendronate and NSAIDs may increase the incidence or severity of ulceration.
journal_name
Life Scijournal_title
Life sciencesauthors
Elliott SN,McKnight W,Davies NM,MacNaughton WK,Wallace JLdoi
10.1016/s0024-3205(97)01040-0subject
Has Abstractpub_date
1998-01-01 00:00:00pages
77-91issue
1eissn
0024-3205issn
1879-0631pii
S0024320597010400journal_volume
62pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.12.025
更新日期:2018-02-15 00:00:00
abstract::This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90277-a
更新日期:1993-01-01 00:00:00
abstract::Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90265-1
更新日期:1986-03-10 00:00:00
abstract::In the present study, we elucidated the possible role of hemodynamic parameters and chemical factors in the development of ventricular hypertrophy (VH) following chronic nitric oxide (NO) deprivation with Nomega-nitro-L-arginine methyl ester (L-NAME). Impedance spectral analysis was used to obtain the arterial hemodyn...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.061
更新日期:2005-11-26 00:00:00
abstract::According to the two-state model of G-protein-coupled receptor (GPCR) activation, GPCRs isomerize from an inactive (R) state to an active (R*) state. In the R* state, GPCRs activate G-proteins. Agonist-independent R/R* isomerization is referred to as constitutive activity and results in an increase in basal G-protein ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(03)00654-4
更新日期:2003-09-19 00:00:00
abstract::Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00612-x
更新日期:2003-10-31 00:00:00
abstract::The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.12.031
更新日期:2006-06-06 00:00:00
abstract::The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90510-x
更新日期:1990-01-01 00:00:00
abstract::The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90626-1
更新日期:1988-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play important roles in fatty acid metabolism. The present study examined the regulation of retinoic acid receptor (RAR alpha, beta, and gamma), RXR (alpha, beta, and gamma), PPAR, cytochrome P450 2E1 (CYP2E1), catalase, and beta-actin gen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00953-8
更新日期:1995-01-01 00:00:00
abstract:AIMS:Major depressive disorder, as a destructive mental health disorder, is a major contributor to disability and death. Numerous studies have illustrated that activation of inflammation and fluctuating immune reactions play a crucial role in the physiopathology of depression. The effectiveness of antidepressants is af...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118501
更新日期:2020-12-01 00:00:00
abstract::The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90649-n
更新日期:1993-01-01 00:00:00
abstract::We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90197-3
更新日期:1985-02-25 00:00:00
abstract:AIMS:To investigate whether hypoxia-inducible factor (HIF) 1alpha and cyclosporin A (CsA) can regulate MICA/B expression and affect NK cytotoxicity during ischemia/reperfusion (I/R) injury. MAIN METHODS:We generated an HIF-1alphaDeltaODD-expressing adenovirus which can functionally and steadily express HIF-1alpha duri...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.05.012
更新日期:2010-07-17 00:00:00
abstract::Resveratrol is an antioxidant present in grapes and their related products. We investigated whether dietary resveratrol could inhibit the proliferation and metastasis of tumors and hyperlipidemia in Donryu rats subcutaneously implanted with an ascites hepatoma cell line of AH109A. By feeding 10 or 50 ppm resveratrol i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00469-7
更新日期:2003-08-01 00:00:00
abstract::The effect of triiodothyronine (T3) on Na+,K(+)-ATPase activity of K562 human erythroleukemic cell was studied to understand why the erythrocyte sodium pump activity is decreased in hyperthyroidism. Na+,K(+)-ATPase activity of K562 cell lysates was assayed by measuring the release of inorganic phosphate (Pi) from ATP....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90107-z
更新日期:1992-01-01 00:00:00
abstract::The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90712-9
更新日期:1983-07-04 00:00:00
abstract::Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01144-2
更新日期:1998-01-01 00:00:00
abstract::Administration of dexamethasone (DEX) during late gestation is a model to study growth restriction in rodents, but the pup's mortality index can be high, depending on DEX dosage, and little is known about the effects of DEX on maternal care (MC). Considering that an inadequate MC can also contribute to pup's mortality...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118599
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116827
更新日期:2019-10-15 00:00:00
abstract:OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.10.003
更新日期:2018-11-01 00:00:00
abstract::Behavioral Hypersensitivity (BH) to dopamine agonists occurs following chronic treatment with most neuroleptics including haloperidol. In the present study we observed that the concurrent administration of thioridazine and haloperidol prevented the development of BH. In contrast, another neuroleptic, fluphenazine, coa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90120-7
更新日期:1986-05-12 00:00:00
abstract::Cilostazol(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone) selectively inhibits cGMP-inhibited phosphodiesterase (PDE3) and is a potent inhibitor of platelet aggregation induced by various agonists. Effect of cilostazol on shear stress-induced human platelet aggregation (SIPA) was examined...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00986-7
更新日期:1997-01-01 00:00:00
abstract:AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118268
更新日期:2020-10-15 00:00:00
abstract::We have recently shown that the vasoconstrictor serotonin (5-HT) inhibits oxygen uptake in perfused hindlimb possibly due to vascular shunting. Thus in the present study the effect of 5-HT on insulin-mediated glucose uptake was assessed. Rat hindlimbs were perfused at constant flow with medium containing 8.3 mM glucos...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90563-i
更新日期:1993-01-01 00:00:00
abstract::The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.02.004
更新日期:2005-07-08 00:00:00
abstract::Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90032-2
更新日期:1983-01-17 00:00:00
abstract::Contractile responses to norepinephrine (NE), and the population of beta-adrenoceptors, were determined in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin (STZ), and age-matched controls. Relaxation and/or contraction of fundus strips of controls and diabetics were induced by 10(-5)M NE....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90505-6
更新日期:1991-01-01 00:00:00
abstract::The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.10.005
更新日期:2006-04-18 00:00:00
abstract::Male Sprague-Dawley rats were castrated and given daily sc. injections of estradiol (E2, 10 micrograms/day), testosterone propionate (TP, 1.0 mg/day), dihydrotestosterone (DHT, 1.0 mg/day) or sesame oil (SO, 0.2 ml/day). A group of sham castrate males received daily sc. injections of SO (0.2 ml/day). On day 8 of stero...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90327-8
更新日期:1984-01-02 00:00:00