Autoradiographic localization of angiotensin II receptors in the rat brainstem.

abstract：:The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function. In recent years, emerging research has found that CD123 is highly expressed on the surface of various cells (e.g., leukemia stem cells, LSCs), and it is associated wit...

journal_title：Life sciences

authors： Liu K,Zhu M,Huang Y,Wei S,Xie J,Xiao Y

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:This study investigated the role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in kidney injury induced by urine-derived sepsis (US). MATERIALS AND METHODS:An Escherichia coli suspension was injected into the distal ureter of adult male Sprague Dawley rats to establish a US model. Lipo...

journal_title：Life sciences

authors： Shen J,Zhang J,Jiang X,Wang H,Pan G

更新日期：2018-10-01 00:00:00

abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

journal_title：Life sciences

authors： Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

更新日期：2013-03-28 00:00:00

abstract：:Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group);...

journal_title：Life sciences

authors： Carmignani M,Volpe AR,Boscolo P,Qiao N,Di Gioacchino M,Grilli A,Felaco M

更新日期：2000-12-15 00:00:00

abstract：AIMS:Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in the respi...

journal_title：Life sciences

authors： Kimura S,Ohi Y,Haji A

更新日期：2015-04-15 00:00:00

abstract：:Six diterpenes (three clerodanes, two abietanes and one rosane) were tested for interactions with the cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism and for effects of nitric oxide production. Two abietane diterpenes, aethiopinone and 11,12-dihydroxy-6-oxo-8,11,13-abietatriene and the rosane lag...

journal_title：Life sciences

authors： de las Heras B,Abad MJ,Silván AM,Pascual R,Bermejo P,Rodríguez B,Villar AM

更新日期：2001-12-07 00:00:00

abstract：AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...

journal_title：Life sciences

authors： Jiao FZ,Wang Y,Zhang WB,Zhang HY,Chen Q,Shi CX,Wang LW,Gong ZJ

更新日期：2019-08-01 00:00:00

abstract：:The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...

journal_title：Life sciences

authors： Winzerling JJ,Jouni ZE,McNamara DJ

更新日期：1996-01-01 00:00:00

abstract：:The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...

journal_title：Life sciences

authors： Mosberg HI,Hurst R,Hruby VJ,Galligan JJ,Burks TF,Gee K,Yamamura HI

更新日期：1983-05-30 00:00:00

abstract：:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibite...

journal_title：Life sciences

authors： Liew HC,Khoo HE,Moore PK,Bhatia M,Lu J,Moochhala SM

更新日期：2007-04-10 00:00:00

abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...

journal_title：Life sciences

authors： Qi LL,Fang SH,Shi WZ,Huang XQ,Zhang XY,Lu YB,Zhang WP,Wei EQ

更新日期：2011-01-03 00:00:00

abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

journal_title：Life sciences

authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

更新日期：2001-08-17 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...

journal_title：Life sciences

authors： Mizoguchi H,Narita M,Nagase H,Suzuki T,Quock RM,Tseng LF

更新日期：1996-01-01 00:00:00

abstract：AIMS:The aim of this study is to determine whether Nkx2.5 transfection of transplanted bone marrow mesenchymal stem cells (MSCs) improves the efficacy of treatment of adriamycin-induced heart failure in a rat model. MAIN METHODS:Nkx2.5 was transfected in MSCs by lentiviral vector transduction. The expressions of Nkx2....

journal_title：Life sciences

authors： Deng B,Wang JX,Hu XX,Duan P,Wang L,Li Y,Zhu QL

更新日期：2017-08-01 00:00:00

abstract：:Nicotine is the main constituent of tobacco smoke responsible for the elevated risk of the cardiovascular disease and sudden coronary death associated with smoking, presumably by provoking cardiac arrhythmias. The cellular mechanisms may be related to the ability of nicotine to prolong action potentials and to depolar...

journal_title：Life sciences

authors： Wang H,Shi H,Wang Z

更新日期：1999-01-01 00:00:00

abstract：:Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic pat...

journal_title：Life sciences

authors： Gruener N,Gross B,Gozlan O,Barak M

更新日期：1994-01-01 00:00:00

abstract：:Vascular endothelial cells have been found to produce a relaxant mediator, identified as nitric oxide (NO) and implicated in numerous physiological functions. Subsequently, there has been an intensive search for accurate and specific detection methods to measure biological NO production. In the present study, we compa...

journal_title：Life sciences

authors： Privat C,Lantoine F,Bedioui F,Millanvoye van Brussel E,Devynck J,Devynck MA

更新日期：1997-01-01 00:00:00

abstract：:We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...

journal_title：Life sciences

authors： Davidson-Garcia CA,Nalbantian-Brandt C,Umans JG

更新日期：2000-02-11 00:00:00

abstract：:The effects of morphine-3-glucuronide (M3G) and morphine on the K+-evoked release of [14C]-gamma-aminobutyric acid (GABA) and [3 H]-glutamic acid were investigated in rat brain synaptosomes using superfusion techniques. K+-evoked release of both [14C]-GABA and [3H]-glutamic acid from rat brain synaptosomes was elimina...

journal_title：Life sciences

authors： Bartlett SE,Smith MT

更新日期：1996-01-01 00:00:00

abstract：:Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and aft...

journal_title：Life sciences

authors： Caldwell JD,Walker CH,Pedersen CA,Mason GA

更新日期：1993-01-01 00:00:00

abstract：:Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...

journal_title：Life sciences

authors： Tanaka H,Masumiya H,Sekine T,Kase J,Kawanishi T,Hayakawa T,Miyata S,Sato Y,Nakamura R,Shigenobu K

更新日期：2001-12-28 00:00:00

abstract：:Prenatal exposure to nicotine has been shown to produce postnatal up-regulation of central nervous system nicotinic receptors and to alter subsequent differentiation of neural tissues. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump ...

journal_title：Life sciences

authors： Slotkin TA,Lappi SE,Tayyeb MI,Seidler FJ

更新日期：1991-01-01 00:00:00

abstract：:Intravenous (IV) administration of 10 ug/kg of morphine sulfate increased the firing rate of Type A dopamine neurons but decreased the extracellular activity of Type B dopamine cells in the substantia nigra pars compacta and ventral tegmental area of anesthetized male rats. The morphine-produced increase in Type A cel...

journal_title：Life sciences

authors： Ostrowski NL,Hatfield CB,Caggiula AR

更新日期：1982-11-15 00:00:00

abstract：:Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...

journal_title：Life sciences

authors： Oyanagui Y,Sato S

更新日期：1993-01-01 00:00:00

abstract：:The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The s...

journal_title：Life sciences

authors： Gosnell BA,Grace M,Billington CJ,Levine AS

更新日期：1989-01-01 00:00:00

abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...

journal_title：Life sciences

authors： Guimarães AG,Scotti L,Scotti MT,Mendonça Júnior FJ,Melo NS,Alves RS,De Lucca Júnior W,Bezerra DP,Gelain DP,Quintans Júnior LJ

更新日期：2014-10-22 00:00:00

abstract：AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to...

journal_title：Life sciences

authors： Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

更新日期：2020-11-01 00:00:00

abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...

journal_title：Life sciences

authors： Jain A,Rani V

更新日期：2018-07-15 00:00:00