当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.

Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.

Abstract：

AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition remain unclear. The goal of this study was to evaluate whether cardiac fibroblast function is altered in a rat model of type II DM. MAIN METHODS:Cardiac fibroblasts were isolated from 14 week old Zucker diabetic and lean control (LC) adult male rat hearts. Fibroblasts were examined for their ability to remodel 3-dimensional collagen matrices, their adhesion, migration and proliferation on collagen and changes in gene expression associated with collagen remodeling. KEY FINDINGS:Cardiac fibroblasts from diabetic animals demonstrated significantly greater ability to contract 3-dimensional collagen matrices compared to cardiac fibroblasts from LC animals. The enhanced contractile behavior was associated with an increase in diabetic fibroblast proliferation and elevated expression of α-smooth muscle actin and type I collagen, suggesting the transformation of diabetic fibroblasts into a myofibroblast phenotype. SIGNIFICANCE:Cardiac fibrosis is a common complication in diabetic cardiomyopathy which may contribute to the observed cardiac dysfunction associated with this disease. Identifying and understanding the changes in fibroblast behavior which contribute to the increased deposition of collagen and other matrix proteins may provide novel therapeutic targets for reducing the devastating effects of diabetes on the heart.

journal_name

Life Sci

journal_title

Life sciences

authors

Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

doi

10.1016/j.lfs.2013.01.003

subject

Has Abstract

pub_date

2013-03-28 00:00:00

pages

669-76

issue

11

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(13)00004-0

journal_volume

92

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy.

    abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.02.033

    authors： Sayyed SG,Kumar A,Sharma SS

    更新日期：2006-07-17 00:00:00

  • Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation.

    abstract：AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.01.005

    authors： Huang CX,Chen N,Wu XJ,He Y,Huang CH,Liu H,Wang WM,Wang HL

    更新日期：2017-02-15 00:00:00

  • Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha.

    abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.11.002

    authors： Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

    更新日期：2017-01-01 00:00:00

  • Spasmolytic and calmodulin inhibitory effect of non-steroidal anti-inflammatory drugs in vitro.

    abstract：:The effect of several anti-inflammatory drugs (NSAIDs), the calmodulin inhibitor W-7 and cortisol on vanadate-induced tonic contraction and on calmodulin dependent cAMP-phosphodiesterase activity have been assayed. Indomethacin, diclofenac, phenylbutazone, mefenamic acid, naproxen, tolmetin, piroxicam, aspirin and W-7...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)02090-6

    authors： Cantabrana B,Perez Vallina JR,Menéndez L,Hidalgo A

    更新日期：1995-01-01 00:00:00

  • Expression of isoforms of NADPH oxidase components in rat pancreatic islets.

    abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.08.031

    authors： Uchizono Y,Takeya R,Iwase M,Sasaki N,Oku M,Imoto H,Iida M,Sumimoto H

    更新日期：2006-12-14 00:00:00

  • The effects of captopril on lipopolysaccharide induced learning and memory impairments and the brain cytokine levels and oxidative damage in rats.

    abstract：AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.10.026

    authors： Abareshi A,Hosseini M,Beheshti F,Norouzi F,Khazaei M,Sadeghnia HR,Boskabady MH,Shafei MN,Anaeigoudari A

    更新日期：2016-12-15 00:00:00

  • Moracin derivatives from Morus Radix as dual BACE1 and cholinesterase inhibitors with antioxidant and anti-glycation capacities.

    abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.08.060

    authors： Seong SH,Ha MT,Min BS,Jung HA,Choi JS

    更新日期：2018-10-01 00:00:00

  • Lithium deficiency reduces thymus weight and alters differential blood count in rats.

    abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00740-6

    authors： Ono T,Iijima M,Shinoda S,Wada O

    更新日期：1997-01-01 00:00:00

  • Contractile responses of the human umbilical artery to KCl and serotonin in Ca-free medium and the effects of levcromakalim.

    abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)02382-2

    authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

    更新日期：2003-02-07 00:00:00

  • Direct determination of homovanillic acid release from the human brain, an indicator of central dopaminergic activity.

    abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90593-z

    authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

    更新日期：1991-01-01 00:00:00

  • Lipid peroxidation: a possible role in gastric damage induced by ethanol in rats.

    abstract：:Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90216-x

    authors： Mizui T,Doteuchi M

    更新日期：1986-06-09 00:00:00

  • Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms.

    abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.071

    authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

    更新日期：2005-11-26 00:00:00

  • Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer.

    abstract：:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATE...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.12.027

    authors： Ma Z,Bao X,Gu J

    更新日期：2019-02-01 00:00:00

  • Somatostatin antagonist analogue stimulates growth in rats.

    abstract：:The somatostatin antagonist analogue cyclo Ahep-Phe-D-Trp-Lys-Thr(Bzl) stimulates growth in young female rats, while somatostatin itself has only equivocal effects on inhibiting growth. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90621-6

    authors： Spencer GS,Hallett KG

    更新日期：1985-07-08 00:00:00

  • Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

    abstract：:We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90429-u

    authors： Thomsen T,Kewitz H

    更新日期：1990-01-01 00:00:00

  • PECAM-1: conflicts of interest in inflammation.

    abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2010.06.001

    authors： Privratsky JR,Newman DK,Newman PJ

    更新日期：2010-07-17 00:00:00

  • L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine.

    abstract：:This study assessed the effects of acute intravenous L-tryptophan (neutral amino acid precursor for serotonin) administration on cocaine-induced dopaminergic responses. Male Sprague-Dawley rats were surgically implanted with guide cannulas in the nucleus accumbens 5 days prior to the study and with vascular catheters ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01276-0

    authors： Molina PE,Ahmed N,Gatley J,Volkow ND,Abumrad NN

    更新日期：2001-09-07 00:00:00

  • pH and thermo dual stimulus-responsive liposome nanoparticles for targeted delivery of platinum-acridine hybrid agent.

    abstract：:The complexes of the type [PtCl(L2)(ACRAMTU)](NO3)2 (ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) were synthesized: PT-ACRAMTU (1), L2 = ethane-1,2-diamine (en); PT(dach)-ACRAMTU (2), L2 = (1R,2R)-1,2-diaminocyclohexane (dach); PT(pda-OH)-ACRAMTU (3), L2 = 2-hydroxy-1,3-propanediamine (pda-OH). The c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.11.052

    authors： Zhou Q,You C,Ling Y,Wu H,Sun B

    更新日期：2019-01-15 00:00:00

  • T-type calcium channel antagonist, TTA-A2 exhibits anti-cancer properties in 3D spheroids of A549, a lung adenocarcinoma cell line.

    abstract：AIMS:Despite the advanced cancer treatments, there is increased resistance to chemotherapy and subsequent mortality. In lack of reliable data in monolayer cultures and animal models, researchers are shifting to 3D cancer spheroids, which represents the in vivo robust tumour morphology. Calcium is essential in cell sign...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118291

    authors： Kumari N,Bhargava A,Rath SN

    更新日期：2020-11-01 00:00:00

  • Paradoxical effects of copper and manganese on brain mitochondrial function.

    abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)00948-1

    authors： Heron P,Cousins K,Boyd C,Daya S

    更新日期：2001-02-23 00:00:00

  • Influence of imidazole on behavioral effects induced by dopaminergic agonists in rats.

    abstract：:Imidazole (IMI) (from 18.7 to 300 mg/Kg) i.p. injected in adult rats induced shaking, which was antagonized by both morphine (MOR) and haloperidol (HALO) but not by methysergide (MET). I.p. IMI pretreatment inhibited the penile erections (PE) and stretching and yawning (SY) typically elicited by N-n-propylnorapomorphi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90046-3

    authors： Francesca F,Baggio G

    更新日期：1985-04-08 00:00:00

  • The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal.

    abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90092-1

    authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

    更新日期：1989-01-01 00:00:00

  • Streptozotocin-induced diabetes increases fructose 2,6-biphosphate levels and glucose metabolism in thymus lymphocytes.

    abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)02312-7

    authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

    更新日期：1996-01-01 00:00:00

  • Role of dietary salt in hypertension.

    abstract：:Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2006.05.017

    authors： Haddy FJ

    更新日期：2006-09-20 00:00:00

  • Muscarinic receptor binding in the mouse heart: the selective modulatory effect of fluoride ion on agonist binding.

    abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90602-6

    authors： Barritt D,Yamamura HI,Roeske WR

    更新日期：1982-03-08 00:00:00

  • Endogenous opioids and ventilatory adaptation to prolonged hypoxia in goats.

    abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90260-8

    authors： Weinberger SE,Steinbrook RA,Carr DB,Fencl V,Gabel RA,Leith DE,Fisher JE,Harris R,Rosenblatt M

    更新日期：1987-02-16 00:00:00

  • Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.

    abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01366-2

    authors： Arnold JC,Hunt GE,McGregor IS

    更新日期：2001-11-21 00:00:00

  • Histone deacetylase inhibitor LMK-235-mediated HO-1 expression induces apoptosis in multiple myeloma cells via the JNK/AP-1 signaling pathway.

    abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.03.011

    authors： Li X,Guo Y,Kuang X,Zhao L,Li H,Cheng B,Wang W,Zhang Z,Liu P,Wang J

    更新日期：2019-04-15 00:00:00

  • The neuronal transport mechanism for noradrenaline is not influenced by the ATP analogue ATP gamma S.

    abstract：:Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake1). There are reports which describe the activity of uptake1 being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a m...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00665-2

    authors： Gliese M,Babin-Ebell J,Schömig E,Russ H

    更新日期：1994-01-01 00:00:00

  • Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.

    abstract：:The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90409-1

    authors： Hammer R,Giraldo E,Schiavi GB,Monferini E,Ladinsky H

    更新日期：1986-05-05 00:00:00