Abstract:
:The effects of morphine-3-glucuronide (M3G) and morphine on the K+-evoked release of [14C]-gamma-aminobutyric acid (GABA) and [3 H]-glutamic acid were investigated in rat brain synaptosomes using superfusion techniques. K+-evoked release of both [14C]-GABA and [3H]-glutamic acid from rat brain synaptosomes was eliminated in the absence of calcium, indicating that K+-evoked neurotransmitter release was from vesicular stores in a manner analagous to that which occurs in vivo following an action potential (1). Addition of M3G or morphine in a range of concentrations (0.1-10 microM) to the superfusion medium did not alter the K+-evoked release of [14C]-GABA or [3H]-glutamic acid from rat brain synaptosomes, suggesting that the CNS excitation observed following central administration of M3G (2-5) and supra-analgesic doses of morphine (2,3,6,7) does not occur by a generalized inhibition of GABA release or facilitation of glutamic acid release from pre-synaptic nerve terminals.
journal_name
Life Scijournal_title
Life sciencesauthors
Bartlett SE,Smith MTdoi
10.1016/0024-3205(95)02310-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
447-54issue
5eissn
0024-3205issn
1879-0631pii
0024320595023100journal_volume
58pub_type
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