Abstract：
:Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and after recovery injected once daily for three consecutive days with 0.5 microgram estradiol benzoate (EB) followed by an injection of 500 micrograms progesterone on the fourth day 4-5 hr before testing. They were either placed in a cage with a sexually-active male until mounted ten times (mounted) or were briefly placed in the cage and removed before being mounted (unmounted). Both groups were then killed and their thymuses aseptically removed. Computerized analysis of saturation binding data showed that the densities of oxytocin receptors from mounted animals were significantly (p < 0.02) lower than those of unmounted controls (beta max for unmounted animals = 8.45 +/- 0.84 fmol/mg protein; and for mounted rats = 5.5 +/- 0.33 fmol/mg protein; t6 = 3.23). The possibility is discussed that sexual activity reduces thymic oxytocin receptors which may alter immune responsiveness to sexually-transmitted diseases.
journal_name
Life Scijournal_title
Life sciencesauthors
Caldwell JD,Walker CH,Pedersen CA,Mason GAdoi
10.1016/0024-3205(93)90467-hsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
1781-6issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(93)90467-Hjournal_volume
52pub_type
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