Abstract：
AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control group, diabetic nephropathy (DN) model group, LBP prevention group, positive control group and LBP treatment group. LBP (10mg/kg) was given to the LBP prevention group after diabetes mellitus (DM) model succeeded for 12weeks and to the LBP treatment group after DN model succeeded for 4weeks. Telmisartan (3.7mg/kg) was given to the positive group after DN model succeeded for 4weeks, and the same volume of balanced saline was given to the normal group and DN group for 12weeks. Urea nitrogen (BUN), creatinine (SCr), and C-reaction protein (CRP) in serum were detected at the end of the 12th week. The expression of MCP-1 mRNA and ICAM-1 mRNA extracted from cortex were detected by RT-PCR. Western blot analysis was carried out to examine NF-κB p65 protein expression. KEY FINDINGS:LBP improves the renal function and alleviates the inflammatory reaction in the kidneys of diabetic rabbits. In addition, the prevention effect of LBP is better than the treatment effect of LBP. SIGNIFICANCE:LBP has obvious protective effect on the diabetic nephropathy rabbits' renal function and postpones the appearance and development of DN. The mechanisms may be related to the reduction the expression of MCP-1mRNA and ICAM-1mRNA by restraining the expression of NF-κB and AngII.
journal_name
Life Scijournal_title
Life sciencesauthors
Zhao Q,Li J,Yan J,Liu S,Guo Y,Chen D,Luo Qdoi
10.1016/j.lfs.2016.05.045subject
Has Abstractpub_date
2016-07-15 00:00:00pages
82-90eissn
0024-3205issn
1879-0631pii
S0024-3205(16)30346-0journal_volume
157pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIM:Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117541
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:HDAC4/5 and Smad7 are potential therapeutic targets for the onset and progression of B-cell acute lymphocytic leukemia (B-ALL) and indices for clinical prognosis. In contrast, HO-1 (heat shock protein 32) plays a key role in protecting tumor cells from apoptosis. METHODS:HDAC4/5, HO-1 and Smad7 expressions in ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.004
更新日期：2018-08-15 00:00:00
abstract：:The acute natriuretic response to atrial peptides (AP) is highly variable in anesthetized rats, and some rats are unresponsive. To determine if this response to AP was affected by dehydration, we measured hematocrit, plasma volume, and natriuresis (delta UNaV) after intravenous injection of 3 micrograms/kg of rat atri...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90149-9
更新日期：1986-06-02 00:00:00
abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.049
更新日期：2016-02-01 00:00:00
abstract：AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.013
更新日期：2012-10-05 00:00:00
abstract：AIMS:The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS:The animals ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.08.013
更新日期：2017-10-01 00:00:00
abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117033
更新日期：2019-12-15 00:00:00
abstract：:Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00735-7
更新日期：1994-01-01 00:00:00
abstract：:Endogenous dopamine (DA) and norepinephrine (NE) in the superfusate from slices of rat medial prefrontal cortex were measured by high-performance liquid chromatography coupled to electrochemical detection (HPLC-ECD). Stimulation with high K+ or methamphetamine (MAP) evoked a dose-dependent elevation in the release of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90356-g
更新日期：1991-01-01 00:00:00
abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90566-2
更新日期：1987-03-16 00:00:00
abstract：:Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90502-9
更新日期：1987-06-15 00:00:00
abstract：:23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomera...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02176-8
更新日期：2002-11-22 00:00:00
abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90189-9
更新日期：1984-09-10 00:00:00
abstract：:The aim of the present study was to investigate the existence of aging- and sex-related alterations in the permeability of the blood-brain barrier (BBB) in the rat, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. We observed that: a) th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90157-m
更新日期：1990-01-01 00:00:00
abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90334-1
更新日期：1987-04-06 00:00:00
abstract：:We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01206-1
更新日期：2001-07-27 00:00:00
abstract：AIMS:Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.028
更新日期：2018-09-15 00:00:00
abstract：:Effects of emodin (EMD) treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion (I-R) injury were examined in male and female rat hearts. Isolated-perfused hearts prepared from female rats were less susceptible to I-R injury than those of male rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.03.027
更新日期：2005-10-14 00:00:00
abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.039
更新日期：2018-05-15 00:00:00
abstract：:Carboxylesterase activity (EC 3.1.1.1) of hen brain including neurotoxic esterases NTEA and NTEB is solubilized from lyophilized lipid-extracted brain material by the use of n-octylglucoside. The solubilized enzymes are subjected to free isoelectric focusing, six carboxyl - esterase activity peaks are obtained. By gel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90082-1
更新日期：1984-03-19 00:00:00
abstract：:Identifying factors that modulate cocaine self-administration is fundamental to the development of effective strategies to treat and prevent cocaine abuse. In the present study, the influence of an alternative reinforcer on the probability of cocaine use was examined in four adult humans under controlled laboratory co...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/0024-3205(94)00878-7
更新日期：1994-01-01 00:00:00
abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117429
更新日期：2020-04-15 00:00:00
abstract：:The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90712-9
更新日期：1983-07-04 00:00:00
abstract：:A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90333-x
更新日期：1987-04-06 00:00:00
abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90644-3
更新日期：1988-01-01 00:00:00
abstract：:The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00904-x
更新日期：1995-01-01 00:00:00
abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117603
更新日期：2020-06-15 00:00:00
abstract：:Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.053
更新日期：2004-03-12 00:00:00
abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90309-2
更新日期：1987-03-09 00:00:00
abstract：:Several cryopreservation methods for precision-cut rat liver slices (PCLS) have been proposed, allowing a short-term (a few hours) maintainance of viability and functionality upon thawing. The aim of the present study was to test the metabolic capacity of PCLS cryopreserved by an ultrarapid method. The biotransformati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01031-1
更新日期：2001-04-13 00:00:00
