Abstract:
:Carboxylesterase activity (EC 3.1.1.1) of hen brain including neurotoxic esterases NTEA and NTEB is solubilized from lyophilized lipid-extracted brain material by the use of n-octylglucoside. The solubilized enzymes are subjected to free isoelectric focusing, six carboxyl - esterase activity peaks are obtained. By gel filtration on Sephacryl S-300 neurotoxic esterases are separated from carboxylesterase isoenzymes V and X. The molecular weight of the neurotoxic esterases is estimated to be 1.8 X 10(6).
journal_name
Life Scijournal_title
Life sciencesauthors
Chemnitius JM,Haselmeyer KH,Zech Rdoi
10.1016/0024-3205(84)90082-1subject
Has Abstractpub_date
1984-03-19 00:00:00pages
1119-25issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(84)90082-1journal_volume
34pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90220-6
更新日期:1985-11-11 00:00:00
abstract::Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2005.05.005
更新日期:2005-08-19 00:00:00
abstract::The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90225-5
更新日期:1985-11-11 00:00:00
abstract::This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00416-x
更新日期:1996-01-01 00:00:00
abstract::The effect of anti beta adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after beta adrenoceptor blockade or after the absorption of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90131-7
更新日期:1987-01-26 00:00:00
abstract::A new simplified procedure for determination of nitric oxide (NO) in biological solutions is described utilizing a new reducing system of nitric oxide prior to chemiluminescence. Advantages of the new method makes heating of the reducing solution unnecessary and avoids cooling and condensation of generated vapors. Onl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90625-y
更新日期:1992-01-01 00:00:00
abstract::Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflamm...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.11.009
更新日期:2018-12-15 00:00:00
abstract::Cilostazol(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone) selectively inhibits cGMP-inhibited phosphodiesterase (PDE3) and is a potent inhibitor of platelet aggregation induced by various agonists. Effect of cilostazol on shear stress-induced human platelet aggregation (SIPA) was examined...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00986-7
更新日期:1997-01-01 00:00:00
abstract::Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.11.025
更新日期:2004-05-21 00:00:00
abstract::miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.117865
更新日期:2020-09-01 00:00:00
abstract:AIMS:Thiamine is an important cofactor present in many biochemical reactions, and its deprivation can lead to heart dysfunction. Little is known about the influence of thiamine deprivation on the electrophysiological behavior of the isolated heart cells and information about thiamine deficiency in heart morphology is c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.03.011
更新日期:2009-06-05 00:00:00
abstract::Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00648-9
更新日期:2003-09-19 00:00:00
abstract:AIMS:We investigated the effects of chemical stimulation of cerebellum fastigial nucleus (FN) on the chronic visceral hypersensitivity (CVH) and its possible mechanism in rats. MAIN METHODS:We stimulated the FN by microinjecting glutamate into the FN, in order to explore whether the cerebellum fastigial nucleus played...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.04.043
更新日期:2018-06-15 00:00:00
abstract::The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.06.022
更新日期:2007-08-02 00:00:00
abstract::A variety of milk proteins including lactoferrin, angiogenin-1, alpha-lactalbumin, beta-lactoglobulin, lactoperoxidase, casein and the novel whey proteins lactogenin and glycolactin were tested for inhibitory activity toward human immunodeficiency virus-1 reverse transcriptase (HIV-1 RT), alpha-glucosidase, beta-gluco...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00853-5
更新日期:2000-10-20 00:00:00
abstract::To study the role of IL-5 in allergic airway hyperreactivity, the time course for the production of cytokines, the infiltration of inflammatory cells and the onset of airway hyperreactivity after three inhalations of antigens were studied in mice. The effect of the soluble alpha-chain of murine recombinant interleukin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90139-2
更新日期:1994-01-01 00:00:00
abstract::The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90308-3
更新日期:1982-05-17 00:00:00
abstract::In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90405-8
更新日期:1983-07-11 00:00:00
abstract:AIMS:Ideally, mesenchymal stem cells (MSC) home to and/or remain at the site of damaged myocardium when administered after myocardial infarction. However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.07.020
更新日期:2008-09-26 00:00:00
abstract::Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.071
更新日期:2005-11-26 00:00:00
abstract::Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90444-8
更新日期:1985-05-20 00:00:00
abstract::1-oleoyl-2-acetyl glycerol (OAG), a potent activator of protein kinase C, inhibited the binding of 125I-labelled epidermal growth factor (EGF) in isolated rat pancreatic acini. Unlike cholecystokinin-octapeptide (CCK8) and the C-kinase activator 12-O-tetradecanoyl phorbol-13-acetate (TPA), two inhibitors of 125I-EGF e...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90129-9
更新日期:1987-04-20 00:00:00
abstract::The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.01.038
更新日期:2007-04-03 00:00:00
abstract:AIMS:Smooth muscle cells (SMCs) play a role in medial vascular calcification, which can be stimulated by high levels of serum phosphate and inflammatory mediators. The aim of this study was to investigate whether mitogen-activated protein kinases (MAPKs) (p38 MAPK, ERK1/2, and JNK) and protein kinase A (PKA) can partic...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.051
更新日期:2018-09-15 00:00:00
abstract::Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90609-f
更新日期:1991-01-01 00:00:00
abstract:AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.08.037
更新日期:2017-11-01 00:00:00
abstract::A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.04.014
更新日期:2006-09-05 00:00:00
abstract:AIM:Evidence suggests that task-specific gait training improves locomotor impairments in people with incomplete spinal cord injury (SCI); however, plastic changes in brain areas remain poorly understood. The aim of this study was to examine the possible effects of a task-specific overground gait training on locomotor r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116627
更新日期:2019-09-01 00:00:00
abstract::Foscarnet inhibited noradrenaline and calcium-mediated contractions of the isolated perfused tail artery of the rat. When the noradrenaline contractile response was split into two components, where the first was due to the release of calcium from intracellular stores and the second to the influx of calcium from the ex...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90541-a
更新日期:1993-01-01 00:00:00
abstract::Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic pat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90159-7
更新日期:1994-01-01 00:00:00