Effect of 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)- 2(1H)-quinolinone (OPC-4392), a newly synthesized agonist for presynaptic dopamine D2 receptor, on tyrosine hydroxylation in rat striatal slices.

abstract：:The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...

journal_title：Life sciences

authors： Li L,Vaali K,Paakkari I,Vapaatalo H

更新日期：1997-01-01 00:00:00

abstract：AIMS:Sodium nitrite is used to inhibit the growth of microorganisms and is responsible for the desirable red color of meat; however, it can be toxic in high quantities for humans and other animals. Moreover, glycogen, a branched polysaccharide, efficiently stores and releases glucose monosaccharides to be accessible fo...

journal_title：Life sciences

authors： Al-Gayyar MM,Alyoussef A,Hamdan AM,Abbas A,Darweish MM,El-Hawwary AA

更新日期：2015-01-01 00:00:00

abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

journal_title：Life sciences

authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

更新日期：2004-01-16 00:00:00

abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...

journal_title：Life sciences

authors： Matlib MA,Schwartz A

更新日期：1983-06-20 00:00:00

abstract：UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...

journal_title：Life sciences

authors： Goverde HJ,van de Venne WP

更新日期：1994-01-01 00:00:00

abstract：AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...

journal_title：Life sciences

authors： Zhao Q,Li J,Yan J,Liu S,Guo Y,Chen D,Luo Q

更新日期：2016-07-15 00:00:00

abstract：:Proteinaceous inhibitors with high inhibitory activities against human neutrophil elastase (HNE) were found in seeds of the Tamarind tree (Tamarindus indica). A serine proteinase inhibitor denoted PG50 was purified using ammonium sulphate and acetone precipitation followed by Sephacryl S-300 and Sephadex G-50 gel filt...

journal_title：Life sciences

authors： Fook JM,Macedo LL,Moura GE,Teixeira FM,Oliveira AS,Queiroz AF,Sales MP

更新日期：2005-05-06 00:00:00

abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

journal_title：Life sciences

authors： Malec D,Langwiński R

更新日期：1983-01-01 00:00:00

abstract：:Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...

journal_title：Life sciences

authors： Wang J,Tokoro T,Matsui K,Higa S,Kitajima I

更新日期：2005-03-25 00:00:00

abstract：AIMS:Long non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC. MAIN METHODS:PURPL and NONHSAT062994 LncRNA...

journal_title：Life sciences

authors： Moridi H,Karimi J,Tavilani H,Khodadadi I,Emami Razavi AN

更新日期：2019-11-15 00:00:00

abstract：:The potency of six antimuscarinic oxotremorine analogs at sympathetic ganglionic M1 and brainstem M2 muscarinic receptors was compared in the rat. Inhibition of the pressor effects of McNA343 or physostigmine was used as functional indicators of M1 and M2 blockade, respectively. 50% inhibitory doses (ID50) were calcul...

journal_title：Life sciences

authors： Vargas HM,Ringdahl B

更新日期：1990-01-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...

journal_title：Life sciences

authors： Morra M,Leboulenger F,Homo-Delarche F,Netchitalo P,Vaudry H

更新日期：1989-01-01 00:00:00

abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...

journal_title：Life sciences

authors： Irvine RJ,White JM,Head RJ

更新日期：1995-02-17 00:00:00

abstract：:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...

journal_title：Life sciences

authors： Cicero TJ,Nock B,O'Connor LH,Sewing BN,Adams ML,Meyer ER

更新日期：1994-01-01 00:00:00

abstract：:To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic renal failure (CRF) with and without clinically evident volume overload, and in patients with end-st...

journal_title：Life sciences

authors： Shenker Y,Port FK,Swartz RD,Gross MD,Grekin RJ

更新日期：1987-09-28 00:00:00

abstract：AIMS:Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair of renal diseases. BIO, a small molecule agonist of this pathway, exerted a protec...

journal_title：Life sciences

authors： Sun Z,Xu S,Cai Q,Zhou W,Jiao X,Bao M,Yu X

更新日期：2020-12-15 00:00:00

abstract：:Two groups of individuals, 26 normotensive normolipemic and 37 normotensive hyperlipemic, all without family history of hypertension have been selected in attempt to demonstrate whether Li-Na countertransport of erythrocytes is influenced by plasma and membrane lipid composition. The maximal rate of Li-Na countertrans...

journal_title：Life sciences

authors： Corrocher R,Ferrari S,Bassi A,Guarini P,Bertinato L,Olivieri O,Licia GM,Ruzzenente O,Brugnara C,De Sandre G

更新日期：1987-08-31 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

journal_title：Life sciences

authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

更新日期：1989-01-01 00:00:00

abstract：AIMS:The renin-angiotensin system (RAS) plays a major role in cardiovascular diseases in postmenopausal women, but little is known about its importance to lower urinary tract symptoms. In this study we have used the model of ovariectomized (OVX) estrogen-deficient rats to investigate the role of RAS in functional and m...

journal_title：Life sciences

authors： Ramos-Filho AC,A Faria J,Calmasini FB,Teixeira SA,Mónica FZ,Muscará MN,Gontijo JA,Anhê GF,Zanesco A,Antunes E

更新日期：2013-11-19 00:00:00

abstract：AIMS:There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-drug memory reconsolidation. GABAergic interneurons in the IC are a potent control on network excitability and play an...

journal_title：Life sciences

authors： Sun K,Xiao L,Wu Y,Zuo D,Zhang C,Liu S,He Z,Rong S,Wang F,Sun T

更新日期：2020-08-01 00:00:00

abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...

journal_title：Life sciences

authors： Graham D,Langer SZ

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study is to report the development of a non-radioactive fluorescent peptide assay for measuring protein kinase C activity (PKC). The assay is based on a glycogen synthase derived fluorescent peptide that is phosphorylated by PKC. Phosphorylation causes the peptide to migrate toward the anode while ...

journal_title：Life sciences

authors： Isbell JC,Christian ST,Mashburn NA,Bell PD

更新日期：1995-01-01 00:00:00

abstract：AIMS:Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold e...

journal_title：Life sciences

authors： Wessler I,Michel-Schmidt R,Brochhausen C,Kirkpatrick CJ

更新日期：2012-11-27 00:00:00

abstract：:The protein inhibitor of nitric oxide synthase (PIN) was independently identified as an inhibitor of nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS), and as a member of the cellular dynein light chain family, dynein light chain 8 (LC8), responsible for intracellular protein trafficking. Mast cells ...

journal_title：Life sciences

authors： McCauley SD,Gilchrist M,Befus AD

更新日期：2007-02-13 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：:Seasonal and diurnal variations in tonic pain reactions were examined in female and male CBA/J mice maintained in a 12/12 dark/light cycle, at controlled temperature and humidity conditions. Animals were injected into the dorsum of one hindpaw with a dilute (20 microl, 1%) formalin solution. Pain-related behaviors wer...

journal_title：Life sciences

authors： Perissin L,Facchin P,Porro CA

更新日期：2003-01-10 00:00:00

abstract：AIMS:Elevated levels of epidermal growth factor (EGF) receptor are observed on several human tumors, e.g. cervical carcinoma and mamma carcinomas. The natural ligand EGF is an alternative to established antibodies and tyrosine kinase inhibitors for targeting EGF receptor-overexpressing tumor cells for therapy. Conjugat...

journal_title：Life sciences

authors： Bachran C,Schneider S,Riese SB,Bachran D,Urban R,Schellmann N,Zahn C,Sutherland M,Fuchs H

更新日期：2011-01-31 00:00:00

abstract：AIM:Evidence suggests that task-specific gait training improves locomotor impairments in people with incomplete spinal cord injury (SCI); however, plastic changes in brain areas remain poorly understood. The aim of this study was to examine the possible effects of a task-specific overground gait training on locomotor r...

journal_title：Life sciences

authors： Ilha J,Meireles A,de Freitas GR,do Espírito Santo CC,Machado-Pereira NAMM,Swarowsky A,Santos ARS

更新日期：2019-09-01 00:00:00