Abstract:
:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha, the stable metabolite of prostacyclin (PGI2). Dopamine also induced a significant inhibition of corticosterone and aldosterone secretion. A lag period of 20 min was observed between inhibition of prostanoid and corticosteroid releases. Prolonged dopamine infusion did not prevent the stimulatory effect of PGE1, PGE2 or arachidonic acid on corticosteroid secretion. These observations indicate that activation of dopaminergic receptors in adrenocortical cells is linked to an inhibition of arachidonic acid metabolism. Our data also suggest that the inhibitory effect of dopamine occurs at a step preceding arachidonic acid formation.
journal_name
Life Scijournal_title
Life sciencesauthors
Morra M,Leboulenger F,Homo-Delarche F,Netchitalo P,Vaudry Hdoi
10.1016/0024-3205(89)90292-0subject
Has Abstractpub_date
1989-01-01 00:00:00pages
175-81issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(89)90292-0journal_volume
45pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90197-3
更新日期:1985-02-25 00:00:00
abstract::Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00734-9
更新日期:1994-01-01 00:00:00
abstract:AIMS:Studies using transgenic mouse strains that incorporate Alzheimer's disease (AD) mutations are valuable for the identification of signaling pathways, potential drug targets, and possible mechanisms of disease that will aid in our understanding of AD. However, reports on the effects of specific AD mutations (Swedis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.04.014
更新日期:2010-06-19 00:00:00
abstract::Human alpha-fetoprotein (AFP) was expressed in Saccharomyces cerevisiae, with a plasmid containing the cDNA sequence for human AFP fused with the rat AFP signal peptide. The recombinant AFP was purified from the yeast lysate by DEAE-cellulose and immunoaffinity chromatography. The amino acid composition and the molecu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90383-3
更新日期:1990-01-01 00:00:00
abstract::Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00638-x
更新日期:2000-06-16 00:00:00
abstract::Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2014.03.025
更新日期:2014-05-28 00:00:00
abstract::Malaria is a major health problem in many countries and according to an estimate of the WHO, more than 500 million infections occur per year. Artemisinin, a sesquiterpene from Artemisia annua L., has received considerable attention as a promising and potent antimalarial drug for its stage speciticity, its rather low t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01447-3
更新日期:2002-01-04 00:00:00
abstract::An increase in natural killer (NK) cell activity can be conditioned with a one trial learning paradigm to demonstrate the interaction between the central nervous system (CNS) and the immune system. In order to demonstrate learning possibilities during 'non-conscious' state, mice were anesthetized with a ketamin/rompun...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90573-8
更新日期:1992-01-01 00:00:00
abstract::Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00337-3
更新日期:1998-01-01 00:00:00
abstract::The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02067-s
更新日期:1995-01-01 00:00:00
abstract::An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90175-0
更新日期:1988-01-01 00:00:00
abstract::The effect of polyamines on the catalytic domain of protein kinase C from rat brain was investigated. It was found that the addition of spermine strongly inhibited phosphorylation activity toward histone H1 as substrate. This tetramine, at millimolar concentrations, was most potently effective while triamines and diam...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90382-7
更新日期:1988-01-01 00:00:00
abstract::We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00413-6
更新日期:2000-02-11 00:00:00
abstract::The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.017
更新日期:2003-11-07 00:00:00
abstract::Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90666-5
更新日期:1983-09-12 00:00:00
abstract::An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90475-x
更新日期:1989-01-01 00:00:00
abstract:AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.11.017
更新日期:2013-02-27 00:00:00
abstract::The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(99)00282-9
更新日期:1999-01-01 00:00:00
abstract::Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as myocardial ischemi...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118628
更新日期:2021-01-01 00:00:00
abstract::Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2003.07.008
更新日期:2003-12-12 00:00:00
abstract::The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90441-d
更新日期:1991-01-01 00:00:00
abstract::Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent diabetes mellitus, and its deposition may contribute to the central nervous system (CNS) manifestations of this disease. Amylin, but not its mRNA, is found in brain, suggesting that CNS amylin is derived from the circulation. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02197-q
更新日期:1995-01-01 00:00:00
abstract::The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90309-2
更新日期:1987-03-09 00:00:00
abstract::Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.036
更新日期:2004-11-19 00:00:00
abstract:AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.04.026
更新日期:2015-08-01 00:00:00
abstract::Estrogen has diverse effects on the vasculature, such as vasodilation, endothelial growth and inhibition of vascular smooth muscle cell (VSMC) proliferation and migration. However, little is known about the genes that are regulated by estrogen in the vascular wall. Wistar rats were ovariectomized or sham-operated (Sha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.03.004
更新日期:2004-07-23 00:00:00
abstract:AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.11.005
更新日期:2012-01-30 00:00:00
abstract::To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.020
更新日期:2005-01-21 00:00:00
abstract:AIM:Up-regulation of inflammasome proteins was reported in dystrophin-deficient muscles. However, it remains to be determined whether inflammasome activation plays a role in the pathogenesis of Duchenne muscular dystrophy. This study was therefore set out to investigate whether genetic disruption of the inflammasome pa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118069
更新日期:2020-09-15 00:00:00
abstract::The purpose of the present studies was to investigate the activity of the adrenal gland and the pituitary beta-endorphin system in individuals from families with a 3 generation history of alcoholism, High Risk group, or from families without history of alcoholism, Low Risk group. All subjects had a medical examination...
journal_title:Life sciences
pub_type: 临床试验,杂志文章
doi:10.1016/0024-3205(89)90167-7
更新日期:1989-01-01 00:00:00