Abstract：
:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg, PO) increased the percentage of entries into open arms and of time spent on open arms. In novel food consumption test, succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle. In the stress-induced hyperthermia test, 40 min after drug administration rectal temperature was measured, succinic acid at dose of 1.5 mg/kg, inhibited stress-induced hyperthermia. Thus, these findings indicated that, in contrast with diazepam, succinic acid exhibits anxiolytic-like effect.
journal_name
Life Scijournal_title
Life sciencesauthors
Chen SW,Xin Q,Kong WX,Min L,Li JFdoi
10.1016/j.lfs.2003.06.017subject
Has Abstractpub_date
2003-11-07 00:00:00pages
3257-64issue
25eissn
0024-3205issn
1879-0631pii
S0024320503008105journal_volume
73pub_type
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