Polyamines and the catalytic domain of protein kinase C.

abstract：:The concentrations and molecular forms of urinary and plasma gastrin from normal subjects were studied by radioimmunoassays using two region-specific antisera. Urinary concentration of NH2-terminal big gastrin (G-34) immunoreactivity was several hundred times as great as that of COOH-terminal gastrin immunoreactivity....

journal_title：Life sciences

authors： Higashimoto Y,Himeno S,Shinomura Y,Kanayama S,Nagao K,Tarui S

更新日期：1990-01-01 00:00:00

abstract：:Galectin-10 (gal-10, also known as Charcot-Leyden crystal protein) is a member of the galectin family of beta-galactoside binding proteins that is expressed uniquely in eosinophilic and basophilic leukocytes. To gain a better understanding of galectin gene expression, we present an analysis of the transcriptional regu...

journal_title：Life sciences

authors： Dyer KD,Rosenberg HF

更新日期：2001-06-01 00:00:00

abstract：:We examined the effects of estrogen, 12-O-tetradecanoylphorbol 13 acetate (TPA), and lipopolysaccharide (LPS) on the gene expression of platelet-derived growth factor (PDGF) by the monocyte/macrophage cell line, THP-1. THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation. Some were treated with...

journal_title：Life sciences

authors： Shanker G,Sorci-Thomas M,Adams MR

更新日期：1995-01-01 00:00:00

abstract：AIMS:Opioid addiction is associated with long-term adaptive changes in the brain that involve protein expression. The carboxyl-terminal of the μ opioid receptor (MOR-C) is important for receptor signal transduction under opioid treatment. However, the proteins that interact with MOR-C after chronic morphine exposure re...

journal_title：Life sciences

authors： Zhou P,Jiang J,Dong Z,Yan H,You Z,Su R,Gong Z

更新日期：2015-12-15 00:00:00

abstract：:Using electric eel acetylcholinesterase (AChE) which was either membrane-bound (AChEm) or solubilized (AChEs), similar kinetics were seen in the absence of inhibitor or in the presence of edrophonium, trimethylammonium ion or paraoxon. Thus, both forms of the enzyme appear to behave similarly toward various inhibitors...

journal_title：Life sciences

authors： Lenz DE,Maxwell DM,Walden MB

更新日期：1984-01-16 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00

abstract：:Our previous research with long term cannabis users established an impaired ability to focus attention and filter out irrelevant information, which was progressive with the cumulative duration of exposure to cannabis. The current study examined these processes in a group of ex-cannabis users. The results suggested a p...

journal_title：Life sciences

authors： Solowij N

更新日期：1995-01-01 00:00:00

abstract：:Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes. Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino...

journal_title：Life sciences

authors： Gessi S,Campi F,Varani K,Borea PA

更新日期：1999-01-01 00:00:00

abstract：:Endomorphin 1 (EM1) and endomorphin 2 (EM2) are highly potent and selective mu-opioid receptor agonists and have significant antinociceptive action. In the mu-selective pocket of endomorphins (EMs), Pro2 residue is a spacer and directs the Tyr1 and Trp3/Phe3 side chains into the required orientation. The present work ...

journal_title：Life sciences

authors： Zhao QY,Chen Q,Yang DJ,Feng Y,Long Y,Wang P,Wang R

更新日期：2005-07-22 00:00:00

abstract：:The initial stage of atherosclerotic plaque formation involves oxidation of the phosphatidyl-choline moiety of low density lipoprotein (LDL) and subsequent uptake by macrophages. Ongoing uptake in developing plaque also may involve oxidized LDL and would require an oxidizing environment in plaque lipids. Atherosclerot...

journal_title：Life sciences

authors： Piotrowski JJ,Shah S,Alexander JJ

更新日期：1996-01-01 00:00:00

abstract：AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...

journal_title：Life sciences

authors： Beckmann DV,Carvalho FB,Mazzanti CM,Dos Santos RP,Andrades AO,Aiello G,Rippilinger A,Graça DL,Abdalla FH,Oliveira LS,Gutierres JM,Schetinger MR,Mazzanti A

更新日期：2014-05-17 00:00:00

abstract：:This study was designed to investigate the effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase N(G), N(G)-asymmetric dimethylarginine (ADMA) in patients and rats with diabetes, and to determine whether elevated endogenous ADMA is implicated in endothelial dysfunction or...

journal_title：Life sciences

authors： Xiong Y,Lei M,Fu S,Fu Y

更新日期：2005-05-27 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine kinetics in mice after a single 1 mg/kg injection of flumazenil. After a single 20 mg/kg i.p. dose of bupivacaine, C max, Vd, Cl and AUC were not significantly modified by flumazenil; even if T max was shown to be significantly shorter when flumazenil...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1993-01-01 00:00:00

abstract：AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...

journal_title：Life sciences

authors： Mustafa S,Ismael HN

更新日期：2017-11-01 00:00:00

abstract：:Effects of ethanol in vitro on membrane vesicles (microsacs prepared from mouse cerebral cortex) were evaluated by monitoring 36Cl- influx. Different assay parameters were tested to determine increased or decreased action of ethanol on GABA-activated chloride channels. The ability of 30 mM ethanol to augment 36Cl- flu...

journal_title：Life sciences

authors： McQuilkin SJ,Harris RA

更新日期：1990-01-01 00:00:00

abstract：:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydro...

journal_title：Life sciences

authors： Mastropaolo D,Camerman A,Ma LY,Camerman N

更新日期：1987-05-18 00:00:00

abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

journal_title：Life sciences

authors： Maccarrone C,Jarrott B

更新日期：1988-01-01 00:00:00

abstract：:A sensitive and specific radioimmunoassay for substance P has been developed and its full characterisation is described. The assay was used to investigate the stability of substance P in tissue in order to establish the optimal conditions of tissue storage for maximal recovery of the peptide. The results indicate unex...

journal_title：Life sciences

authors： McGregor GP,Bloom SR

更新日期：1983-02-07 00:00:00

abstract：:The effects of eight catechin derivatives on vascular tone in rat thoracic aorta were examined. Catechin derivatives (10 microM) potentiated the contractile response to phenylephrine in endothelium-intact arteries. The potentiations produced by EGCg and EGC were almost absent in endothelium-denuded arteries and abolis...

journal_title：Life sciences

authors： Sanae F,Miyaichi Y,Kizu H,Hayashi H

更新日期：2002-10-11 00:00:00

abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...

journal_title：Life sciences

authors： Delgado-Marín L,Sánchez-Borzone M,García DA

更新日期：2017-04-15 00:00:00

abstract：:Using a two-lever drug discrimination procedure, six rats were trained to discriminate 0.5 mg/kg of racemic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) from saline. Once trained, the animals demonstrated a dose-related decrease in discriminative performance upon administration of lower doses of DOI (ED50 = 0.1...

journal_title：Life sciences

authors： Glennon RA

更新日期：1986-09-01 00:00:00

abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

journal_title：Life sciences

authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

更新日期：2001-08-17 00:00:00

abstract：AIMS:Idiopathic pulmonary fibrosis continues to be a devastating clinical disorder for which there are few therapeutic options, and the pathogenesis of this disease remains largely unknown. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in cholesterol biosynthesis, and they have been reported...

journal_title：Life sciences

authors： Oka H,Ishii H,Iwata A,Kushima H,Toba S,Hashinaga K,Umeki K,Tokimatsu I,Hiramatsu K,Kadota J

更新日期：2013-12-18 00:00:00

abstract：:The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...

journal_title：Life sciences

authors： Kim WK,Jung JW,Ahn NY,Oh HR,Lee BK,Oh JK,Cheong JH,Chun HS,Ryu JH

更新日期：2004-10-22 00:00:00

abstract：AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...

journal_title：Life sciences

authors： Yan G,Li S,Yue M,Li C,Kang Z

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...

journal_title：Life sciences

authors： Liu J,Xu Y,Wu Q,Ding Q,Fan W

更新日期：2018-11-01 00:00:00

abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...

journal_title：Life sciences

authors： Seong SH,Ha MT,Min BS,Jung HA,Choi JS

更新日期：2018-10-01 00:00:00

abstract：:Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these events by pharmacologically active agent gain predominance in cancer treatment. In current investigation Solanidine, a steroidal alkaloid was evaluated on tumori...

journal_title：Life sciences

authors： Malojirao VH,Vigneshwaran V,Thirusangu P,Mahmood R,Prabhakar BT

更新日期：2018-04-15 00:00:00

abstract：:An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1,...

journal_title：Life sciences

authors： Nordberg LO,Raffa RB,Tallarida RJ

更新日期：1993-01-01 00:00:00

abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

journal_title：Life sciences

authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

更新日期：1995-03-03 00:00:00