Subcellular distribution of choline acetyltransferase by immunogold electron microscopy in non-neuronal cells: placenta, airways and murine embryonic stem cells.

abstract：:We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 produ...

journal_title：Life sciences

authors： Funaki N,Arii S,Adachi Y,Higashituji H,Tanaka J,Imamura M

更新日期：1993-01-01 00:00:00

abstract：:Secreted frizzled-related protein 5 (Sfrp5) primarily acts in combination with wingless-type family member 5a (Wnt5a), to inhibits chronic inflammation and repress atherosclerosis and other metabolic disorders. Epicardial adipose tissue (EAT), surrounding the heart and coronary arteries, has been found to be highly re...

journal_title：Life sciences

authors： Tong S,Du Y,Ji Q,Dong R,Cao J,Wang Z,Li W,Zeng M,Chen H,Zhu X,Zhou Y

更新日期：2020-03-15 00:00:00

abstract：AIMS:The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS:The animals ...

journal_title：Life sciences

authors： Kalayci M,Kocdor MA,Kuloglu T,Sahin İ,Sarac M,Aksoy A,Yardim M,Dalkilic S,Gursu O,Aydin S,Akkoc RF,Ugras M,Artas G,Ozercan İH,Ugur K,Aydin S

更新日期：2017-10-01 00:00:00

abstract：:Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susce...

journal_title：Life sciences

authors： Jarman J,Glover V,Sandler M

更新日期：1991-01-01 00:00:00

abstract：AIMS:Studies on diabetes mellitus have shown that the phosphoinositide 3-kinase (PI3K)/serine threonine kinase (AKT)/forkhead box protein O1 (FoxO1) signaling pathway can regulate insulin secretion by modulating the expression of pancreatic and duodenal homeobox-1 (PDX-1). Therefore, it was hypothesized that the pathwa...

journal_title：Life sciences

authors： Zhang B,Sun P,Shen C,Liu X,Sun J,Li D,Liu Z,Zhang W,Zhang K,Niu Y

更新日期：2020-10-01 00:00:00

abstract：:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...

journal_title：Life sciences

authors： Mallet PE,Beninger RJ

更新日期：1998-01-01 00:00:00

abstract：:During the myocardial protection induced by ischemic preconditioning a reduction in myocardial metabolism occurs due to activation of the A1 adenosine receptors. This study investigates whether preconditioning changes both resting coronary flow and the magnitude of coronary reactive hyperemia and whether A1 adenosine ...

journal_title：Life sciences

authors： Pagliaro P,Penna C,Gattullo D

更新日期：1999-01-01 00:00:00

abstract：:Ether à go-go (EAG) potassium channels possess oncogenic properties and have gained great interest as research tools for cancer detection and therapy. Besides, EAG electrophysiological properties are regulated through the cell cycle and determined by cytoskeletal interactions. Thus, because of the pivotal role of extr...

journal_title：Life sciences

authors： Toral C,Mendoza-Garrido ME,Azorín E,Hernández-Gallegos E,Gomora JC,Delgadillo DM,Solano-Agama C,Camacho J

更新日期：2007-06-27 00:00:00

abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...

journal_title：Life sciences

authors： Raffa RB,Porreca F

更新日期：1989-01-01 00:00:00

abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...

journal_title：Life sciences

authors： Matsuyama S,Shuntoh H,Katayama S,Tanaka C

更新日期：1993-01-01 00:00:00

abstract：:To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previously. Plasma ghrelin levels were measured by both N-RIA recognizing th...

journal_title：Life sciences

authors： Okimura Y,Ukai K,Hosoda H,Murata M,Iguchi G,Iida K,Kaji H,Kojima M,Kangawa K,Chihara K

更新日期：2003-04-18 00:00:00

abstract：:The ability of selective mu- ([D-Ala2, NHPhe4, Gly-ol]enkephalin: DAMGO), delta1- ([D-Pen2, Pen5]enkephalin: DPDPE) and delta2- ([D-Ala2]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[35...

journal_title：Life sciences

authors： Tsuji M,Narita M,Mizoguchi H,Narita M,Ohsawa M,Kamei J,Nagase H,Takeda H,Matsumiya T,Tseng LF

更新日期：1999-01-01 00:00:00

abstract：:The present study was designed to investigate the effect of partial (two-thirds) hepatectomy (PH) on hepatic and intestinal glutathione S-transferases (GSTs) activities. A significant decrease of cytosolic hepatic GSTs activity was observed after the PH. The lowest value of hepatic GSTs was obtained 48 h after the sur...

journal_title：Life sciences

authors： Carnovale CE,Monti JA,Favre C,Scapini C,Carrillo MC

更新日期：1995-01-01 00:00:00

abstract：:Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity. ...

journal_title：Life sciences

authors： Sugg EE,Shook JE,Serra M,Korc M,Yamamura HI,Burks TF,Hruby VJ

更新日期：1986-11-03 00:00:00

abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

journal_title：Life sciences

authors： Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

更新日期：2021-01-15 00:00:00

abstract：:To characterize the mechanism of the analgesic action of H1 antihistaminics the effects of a new, highly selective agonist, 2-(3-trifluoromethylphenyl)histamine dihydrogenmaleate (FMPH), and of the better known H1 agonist, 2-thiazolylethylamine (2-TEA), were studied on pain threshold by means of three different kinds ...

journal_title：Life sciences

authors： Malmberg-Aiello P,Lamberti C,Ipponi A,Bartolini A,Schunack W

更新日期：1998-01-01 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...

journal_title：Life sciences

authors： Hu QW,Liu GT

更新日期：2006-07-04 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：AIMS:Histone modifications play central epigenetic roles in regulating the entire genome of the cell and cell proliferation. Herein, we investigated the effects of the natural compound, 16-hydroxycleroda-3,13-dien-15,16-olide (PL3), on the expressions of histone-modifying enzymes, and examined how it induces apoptosis ...

journal_title：Life sciences

authors： Lin YH,Lee CC,Chang FR,Chang WH,Wu YC,Chang JG

更新日期：2011-12-05 00:00:00

abstract：:The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly r...

journal_title：Life sciences

authors： Matsumoto S,Isshiki A,Watanabe Y,Wieloch T

更新日期：2002-12-20 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular diseases, including atherosclerosis. However, the regulatory mechanis...

journal_title：Life sciences

authors： Wu X,Zheng X,Cheng J,Zhang K,Ma C

更新日期：2020-02-15 00:00:00

abstract：:Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

journal_title：Life sciences

authors： Fischman AJ,Kastin AJ,Graf MV

更新日期：1984-11-12 00:00:00

abstract：AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...

journal_title：Life sciences

authors： Woodman OL,Malakul W

更新日期：2009-07-03 00:00:00

abstract：:Three forms of alkaline phosphatase have been isolated from different sections of the small intestine: F3 180 kDa from the duodenum; F2 150 kDa principally jejunal; F1 120 kDa the only ileal form. Their catalytic properties have been compared as well as the electrophoretic properties the dimer and monomer of their pho...

journal_title：Life sciences

authors： Tardivel S,Razanamaniraka L,Porembska Z,Crouzoulon G,Fournier P,Dupuis Y

更新日期：1988-01-01 00:00:00

abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...

journal_title：Life sciences

authors： Miller KE,Brooks RR,Bonk KR,Carpenter JF

更新日期：1991-01-01 00:00:00

abstract：:The effects of pretreatment with selective mu-, delta- and kappa-opioid receptor antagonists on the enhancement of the pentobarbital-induced loss of the righting reflex by morphine were examined in mice. Mice injected with pentobarbital (50 mg/kg, i.p.) showed an increased duration for the loss of the righting reflex ...

journal_title：Life sciences

authors： Kamei J,Ohsawa M,Nagase H

更新日期：1996-01-01 00:00:00

abstract：:Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...

journal_title：Life sciences

authors： Jenks BG,van Zoest ID,de Koning HP,Leenders HJ,Roubos EW

更新日期：1991-01-01 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...

journal_title：Life sciences

authors： Huang H,Chan H,Wang YY,Ouyang DY,Zheng YT,Tam SC

更新日期：2006-08-22 00:00:00

abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...

journal_title：Life sciences

authors： Fujie H,Hayashi I,Oh-ishi S

更新日期：1993-01-01 00:00:00