Abstract：
:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sired by alcohol-treated males: litter sizes were appreciably smaller (30%) and fetal mortality was more than 2 times higher than in controls. These results suggest that paternal alcohol use, like maternal alcohol abuse, may adversely affect fertility and fetal outcome.
journal_name
Life Scijournal_title
Life sciencesauthors
Cicero TJ,Nock B,O'Connor LH,Sewing BN,Adams ML,Meyer ERdoi
10.1016/0024-3205(94)90109-0subject
Has Abstractpub_date
1994-01-01 00:00:00pages
PL33-6issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(94)90109-0journal_volume
55pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90170-v
更新日期：1990-01-01 00:00:00
abstract：:Stimulation of the preganglionic trunk of the ipsilateral superior cervical sympathetic ganglion with square wave electrical pulses produced secretion from the main excretory duct of the rabbit lacrimal gland. The secretion was inhibited by propranolol (1 mg/kg) and metoprolol (10 mg/kg) but not by phenoxybenzamine (2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90424-7
更新日期：1984-06-11 00:00:00
abstract：:Previous studies with N-terminal fragments of substance P (SP) have suggested the existence of two separate SP receptor populations. SP1 receptors are found in guinea pig ilea and rat colons. SP2 receptors are found in mouse spinal cords and rat salivary glands. We have now found that substitution of Gly9 in substance...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90198-5
更新日期：1985-02-25 00:00:00
abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)01021-3
更新日期：2001-02-02 00:00:00
abstract：:Electroshock induced seizures in the rat enhanced high affinity specific Na+ independent binding of 3H-gamma aminobutyric acid (GABA) to frozen, Triton X-100 treated cerebral synaptic membranes 30 minutes after exposures to electroshock, although no change in 3H GABA binding was observed in similarly treated preparati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90756-1
更新日期：1982-11-29 00:00:00
abstract：AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117814
更新日期：2020-08-15 00:00:00
abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.011
更新日期：2009-02-27 00:00:00
abstract：AIMS:Few studies have compared the interaction of single and repeated administration of amitriptyline (amit) with the nitrergic system and glutamatergic system in the experimental model of neuropathic pain. We aimed to evaluate the antinociceptive effect of single and repeated administration of amit and to assess wheth...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116752
更新日期：2019-09-15 00:00:00
abstract：:The effects of naloxone, an opiate "pure" receptor antagonist, on the release of prolactin and corticosterone in the rat were studied following the administration of the serotonin precursor 5-hydroxytryptophan or the serotonin receptor agonist (-) -m-chlorophenylpiperazine. Naloxone clearly antagonizes the release of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90367-3
更新日期：1983-05-23 00:00:00
abstract：:The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was develope...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90163-3
更新日期：1986-11-03 00:00:00
abstract：:The aim of the study was to assess how the interruption of enterohepatic circulation may affect the regulation of apolipoprotein synthesis. For this purpose, apolipoprotein mRNA levels were measured in the liver and small intestine of male Wistar rats fed for 3 weeks diets with or without cholestyramine (5% w/w). In o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00640-7
更新日期：1994-01-01 00:00:00
abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.12.016
更新日期：2014-01-24 00:00:00
abstract：AIMS:β-Adrenoceptors (β-ADRs) mediating the relaxation of rat superior mesenteric arteries (SMAs) were pharmacologically identified, and the effects of chemical sympathetic denervation on β-ADR-mediated relaxation were examined. MAIN METHODS:The tension changes of endothelium-denuded SMAs were isometrically recorded a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117155
更新日期：2020-01-15 00:00:00
abstract：:The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2011.04.020
更新日期：2011-10-10 00:00:00
abstract：:Palytoxin induced increases in cytosolic Ca2+ and tension, which were dependent on external Ca2+, and depolarized the membrane in endothelium-denuded porcine coronary arteries. When the endothelium was present, however, these effects were greatly inhibited, suggesting that some factors from endothelium inhibited the p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00682-0
更新日期：1997-01-01 00:00:00
abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117989
更新日期：2020-09-01 00:00:00
abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90248-5
更新日期：1983-08-15 00:00:00
abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90335-m
更新日期：1992-01-01 00:00:00
abstract：:The effect of endothelin (END) on the release of atrial natriuretic peptides (ANP) was studied in isolated rat atria and in conscious rats. END stimulates the ANP release in vitro in a dose-dependent manner. An increase in ANP plasma levels and cyclic GMP plasma levels was also observed in conscious rats after injecti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90200-2
更新日期：1989-01-01 00:00:00
abstract：:Morphine sulfate and other opiate/narcotic analgesics are the most effective treatments for acute and chronic severe pain. However, their clinical utility is often hampered by the development of analgesic tolerance. This complex pathophysiological cycle contributes significantly to decreased quality of life in the gro...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2009.06.011
更新日期：2010-04-10 00:00:00
abstract：:In primary cultured bovine adrenal chromaffin cells (BACC), pituitary adenylate cyclase activating polypeptide 1-38 (PACAP) produced a dose related increase in tyrosine hydroxylase (TH) Vmax when measured 48 hours after the beginning of the treatment; a significant increase was observed with 0.5 nM and the maximal ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00614-8
更新日期：1994-01-01 00:00:00
abstract：:A number of potential functions of thioredoxin have been proposed in literature, including a role for DNA replication. The aim of our study was to investigate the effects of thioredoxin from Streptomyces aureofaciens (Trx S.a.) on plasmid DNA. Trx S.a. was incubated with plasmid forms and the incubation product(s) cha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01133-8
更新日期：1998-01-01 00:00:00
abstract：:Two proteinous factors, designated here as ram p25 GDP dissociation inhibitor (I) and (II) (ram-GDI (I) and (II)), were detected in the cytosolic fraction of rat spleen, which inhibited the initial dissociation of GDP from ram p25 produced by E. coli by causing characteristic lag. They had very weak effects on the rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90455-x
更新日期：1992-01-01 00:00:00
abstract：:We used a sensitive and specific radioimmunoassay for acetylcholine (ACh), and detected significant amounts of ACh in the blood of various mammals, including humans. About 60% of human blood ACh was localized in mononuclear leukocytes. Human leukemic T-cell lines, used as T-lymphocyte models, contained both ACh and ch...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(98)00131-3
更新日期：1998-01-01 00:00:00
abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00117-3
更新日期：1997-01-01 00:00:00
abstract：:The release of liver enzymes is typically used to assess tissue damage following ischemia-reperfusion. The present study was designed to determine the impact of ischemia-reperfusion on liver function and compare these findings with enzyme release. Isolated, perfused rat livers were subjected to low flow ischemia follo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00668-2
更新日期：2000-01-01 00:00:00
abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.07.038
更新日期：2004-01-16 00:00:00
abstract：:We previously demonstrated that tissue-type plasminogen activator (t-PA) specifically bound to its receptor (t-PAR) on human umbilical vein endothelial cells (HUVEC). In addition to analyses of t-PA binding to plasminogen activator inhibitor-1 (PAI-1) in the extracellular matrix (ECM) and to the t-PAR, we further eval...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)80007-7
更新日期：2000-01-01 00:00:00
abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.020
更新日期：2009-02-13 00:00:00
abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01507-2
更新日期：2002-04-05 00:00:00
