Ouabain--a local, paracrine, aldosterone synthesis regulating hormone?

abstract：:Viperid, elapid and crotalid snake venoms were screened in vitro for antiviral activity against Sendai virus. The hemolysis of 10(8) human erythrocytes in 1 ml, caused by 70 HAU of Sendai virus, was abolished when the virions were pretreated with 10 ug of the viperid venom of Echis coloratus, and was considerably dimi...

journal_title：Life sciences

authors： Borkow G,Ovadia M

更新日期：1992-01-01 00:00:00

abstract：:Decreased sweat secretion is a primary side effect of topiramate in pediatric patients, but the mechanism underlying this effect remains unclear. This study aimed to better understand how topiramate decreases sweat secretion by examining its effect on the expression of carbonic anhydrase (CA) II and aquaporin-5 (AQP5)...

journal_title：Life sciences

authors： Ma L,Huang YG,Deng YC,Tian JY,Rao ZR,Che HL,Zhang HF,Zhao G

更新日期：2007-06-06 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...

journal_title：Life sciences

authors： Deng P,Zuo Y,Feng S,Li Z,Chen W,Li H,Wang X

更新日期：2018-12-15 00:00:00

abstract：:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...

journal_title：Life sciences

authors： Stuart EC,Scandlyn MJ,Rosengren RJ

更新日期：2006-11-17 00:00:00

abstract：:Human milk was tested in the Ames plate incorporation test using strain TA98. Pools from smokers and non-smokers respectively, as well as individual samples from 14 smokers and 15 controls were tested. No difference was found between milk from smokers and non-smokers in the concentrations and volumes used. Preliminary...

journal_title：Life sciences

authors： Rivrud GN,Hagen I,Børresen AL

更新日期：1987-11-23 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:A monoclonal antibody (C351) against alpha human atrial natriuretic polypeptide (alpha hANP) recognizing human form ring structure was established and applied to a radioimmunoassay of plasma alpha hANP. The minimum detectable amount in terms of 10% radioligand displacement relative to zero dose were 0.28 fmol/tube, co...

journal_title：Life sciences

authors： Naomi S,Umeda T,Iwaoka T,Miura F,Ohno M,Sasaki M,Oishi S,Sato T,Takatsu K

更新日期：1988-01-01 00:00:00

abstract：:A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans. However no previous studies have compared the effects of the most potent pharmacological agonist and antagonist, morphine and naloxone, in the same subjects. The present study examined the acute effect...

journal_title：Life sciences

authors： Petraglia F,Porro C,Facchinetti F,Cicoli C,Bertellini E,Volpe A,Barbieri GC,Genazzani AR

更新日期：1986-06-09 00:00:00

abstract：:The effects of adenosine on the amylase secretion from rat pancreatic lobules have been studied. Adenosine induces a dose-dependent stimulation on amylase release, which is maximal at a concentration of 10(-4) M. It has been observed a clear inhibition of this secretory action when atropine was added whereas no amylas...

journal_title：Life sciences

authors： Rodríguez-Nodal F,San Román JI,López-Novoa JM,Calvo JJ

更新日期：1995-01-01 00:00:00

abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...

journal_title：Life sciences

authors： Kuo CW,Shen CJ,Tung YT,Chen HL,Chen YH,Chang WH,Cheng KC,Yang SH,Chen CM

更新日期：2015-08-15 00:00:00

abstract：:Certain pharmacological properties of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, have been investigated in chicks. Although beta-CCM has been established previously as an "inverse agonist" of benzodiazepine receptors in rodents, having effects opposite to those of benzodiazepines...

journal_title：Life sciences

authors： Venault P,Prado de Carvalho L,Brown CL,Dodd RH,Rossier J,Chapouthier G

更新日期：1986-09-22 00:00:00

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：AIMS:Sickle cell disease (SCD) pathogenesis leads to recurrent vaso-occlusive and hemolytic processes, causing numerous clinical complications including renal damage. As vasoconstrictive mechanisms may be enhanced in SCD, due to endothelial dysfunction and vasoactive protein production, we aimed to determine whether th...

journal_title：Life sciences

authors： dos Santos AF,Almeida CB,Brugnerotto AF,Roversi FM,Pallis FR,Franco-Penteado CF,Lanaro C,Albuquerque DM,Leonardo FC,Costa FF,Conran N

更新日期：2014-11-04 00:00:00

abstract：AIMS:Idiopathic pulmonary fibrosis continues to be a devastating clinical disorder for which there are few therapeutic options, and the pathogenesis of this disease remains largely unknown. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in cholesterol biosynthesis, and they have been reported...

journal_title：Life sciences

authors： Oka H,Ishii H,Iwata A,Kushima H,Toba S,Hashinaga K,Umeki K,Tokimatsu I,Hiramatsu K,Kadota J

更新日期：2013-12-18 00:00:00

abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

journal_title：Life sciences

authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

更新日期：2005-04-01 00:00:00

abstract：AIMS:In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats. MATERIALS AND METHODS:Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+...

journal_title：Life sciences

authors： Ma C,Pan Y,Yang Z,Meng Z,Sun R,Wang T,Fei Y,Fan W

更新日期：2016-01-01 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00

abstract：AIMS:Oxidative stress has been largely implicated in the pathogenesis of anoxia/reoxygenation injury. Ganoderma atrum polysaccharide (PSG-1), the most abundant component extracted from the fruiting bodies of G. atrum, has been shown to possess potent antioxidant activity. In this study, we investigated whether PSG-1 at...

journal_title：Life sciences

authors： Li WJ,Nie SP,Yan Y,Zhu SB,Xie MY

更新日期：2009-10-21 00:00:00

abstract：AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...

journal_title：Life sciences

authors： Zhao Q,Li J,Yan J,Liu S,Guo Y,Chen D,Luo Q

更新日期：2016-07-15 00:00:00

abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

journal_title：Life sciences

authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

更新日期：2017-08-15 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00

abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...

journal_title：Life sciences

authors： Raffa RB,Porreca F

更新日期：1989-01-01 00:00:00

abstract：:Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of gua...

journal_title：Life sciences

authors： Yamaji Y,Natsumeda Y,Yamada Y,Irino S,Weber G

更新日期：1990-01-01 00:00:00

abstract：:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effe...

journal_title：Life sciences

authors： MacMurray JP,Barker JP,Armstrong JD,Bozzetti LP,Kuhn IN

更新日期：1983-05-16 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...

journal_title：Life sciences

authors： Huang H,Chan H,Wang YY,Ouyang DY,Zheng YT,Tam SC

更新日期：2006-08-22 00:00:00

abstract：:This work explored cellular trapping and extrusion of Cd and Hg in epithelial cells, with special emphasis on the jejunal mucosa. Important determinants of these processes are the concentration, diffusibility and relative metal affinities of a variety of cellular metal-binding compounds including metallothionein (MT)....

journal_title：Life sciences

authors： Foulkes EC

更新日期：1993-01-01 00:00:00

abstract：:2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...

journal_title：Life sciences

authors： Schiller PW,Weltrowska G,Nguyen TM,Lemieux C,Chung NN,Lu Y

更新日期：2003-06-27 00:00:00