Ouabain--a local, paracrine, aldosterone synthesis regulating hormone?

abstract：AIMS:As of the 28th April 2020, the COVID-19 pandemic has infiltrated over 200 countries and affected over three million confirmed people. We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. METHODS:A systematic review of the lit...

journal_title：Life sciences

authors： Kermali M,Khalsa RK,Pillai K,Ismail Z,Harky A

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Sepsis is a life-threatening organ dysfunction syndrome arising from uncontrolled inflammatory responses. Liver injury is a crucial factor for the prognosis of sepsis. Camptothecins (CPTs) have been reported to suppress the inflammatory response induced by sepsis. G2, a CPT-bile acid conjugate...

journal_title：Life sciences

authors： Xiao LX,Qi L,Zhang XL,Zhou YQ,Yue HL,Yu ED,Li QY

更新日期：2020-09-15 00:00:00

abstract：:The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...

journal_title：Life sciences

authors： Akil H,Shiomi H,Thompson R,Lax S,Coy D,Watson S

更新日期：1982-11-15 00:00:00

abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

journal_title：Life sciences

authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

更新日期：1999-01-01 00:00:00

abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...

journal_title：Life sciences

authors： Bäck M

更新日期：2002-06-28 00:00:00

abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

journal_title：Life sciences

authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

更新日期：2004-01-16 00:00:00

abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...

journal_title：Life sciences

authors： Hale CC,Rovetto MJ

更新日期：1995-01-01 00:00:00

abstract：:Hydroxyethyl starch (HES) found in rat serum and spleen after single and daily administrations of 0.9 g/kg for 1 week was characterized by gas-liquid chromatography. There was very little difference in the degree of substitution (D.S.) and molar substitution (M.S.) of HES in serum samples obtained at 1 hour and 57 day...

journal_title：Life sciences

authors： Sum CY,Lai CM,Yacobi A,Kalhorn TF

更新日期：1983-11-14 00:00:00

abstract：:Restraint stress is known to induce gastric ulcers in rats. Peripheral sympathetic activity and catecholamines are involved in the pathogenesis of these gastric ulcers. The aim of the present study was to evaluate the effects of restraint on mucosal and muscle catecholamine concentrations in the glandular stomach of r...

journal_title：Life sciences

authors： Gaudin C,Safar M,Cuche JL

更新日期：1990-01-01 00:00:00

abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

journal_title：Life sciences

authors： Storlien LH

更新日期：1985-02-11 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：:U-54494A, a 1,2-diamine anticonvulsant, and U-50488H, a structurally related agonist for opiate kappa receptors, were tested for effects on spontaneous and glutamate-evoked firing rates in cerebral cortex of urethane-anesthetized male Sprague-Dawley rats. Iontophoretic application of 1,2-diamines, glutamate diethyl et...

journal_title：Life sciences

authors： Ochoa MC,Vogelsang GD,Lum JT,VonVoigtlander PF,Piercey MF

更新日期：1992-01-01 00:00:00

abstract：:Thymol induced superoxide production (O2-) by blood leukocytes was examined in various primates including man. Leukocytes of chimpanzee and hamadryas baboon cells showed only 35% of the maximal O2- production rate obtained in human cells, and those of the Japanese monkey and orang-utan failed to respond. In contrast, ...

journal_title：Life sciences

authors： Suzuki Y,Nakamura S,Sugiyama K,Furuta H

更新日期：1987-09-28 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. ...

journal_title：Life sciences

authors： Wu Y,Tu X,Lin G,Xia H,Huang H,Wan J,Cheng Z,Liu M,Chen G,Zhang H,Fu J,Liu Q,Liu DX

更新日期：2007-10-13 00:00:00

abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...

journal_title：Life sciences

authors： Zabetian CP,Staley JK,Flynn DD,Mash DC

更新日期：1994-01-01 00:00:00

abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...

journal_title：Life sciences

authors： de Lima Portella R,Barcelos RP,de Bem AF,Carratu VS,Bresolin L,da Rocha JB,Soares FA

更新日期：2008-12-19 00:00:00

abstract：:The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertensi...

journal_title：Life sciences

authors： Yoneda T,Kihara Y,Ohkusa T,Iwanaga Y,Inagaki K,Takeuchi Y,Hayashida W,Ueyama T,Hisamatsu Y,Fujita M,Hatac S,Matsuzaki M,Sasayama S

更新日期：2001-11-30 00:00:00

abstract：AIMS:The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model. MAIN METHODS:Rats were randomized to normothermia (n = 10) or ...

journal_title：Life sciences

authors： Shi J,Dai W,Carreno J,Hale SL,Kloner RA,Kay GL

更新日期：2019-07-15 00:00:00

abstract：:Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...

journal_title：Life sciences

authors： Mennini T,Gobbi M

更新日期：2004-07-16 00:00:00

abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...

journal_title：Life sciences

authors： Olson JW

更新日期：1985-12-09 00:00:00

abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...

journal_title：Life sciences

authors： Kimes AS,Smith WJ,Winchell CJ,London ED

更新日期：1992-01-01 00:00:00

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

journal_title：Life sciences

authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

更新日期：2005-04-01 00:00:00

abstract：:Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA ther...

journal_title：Life sciences

authors： Siu FK,Lo SC,Leung MC

更新日期：2004-07-30 00:00:00

abstract：AIMS:Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98-105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is u...

journal_title：Life sciences

authors： Wang M,Shibamoto T,Kuda Y,Tanida M,Zhang T,Song J,Kurata Y

更新日期：2016-02-15 00:00:00

abstract：:The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...

journal_title：Life sciences

authors： Shokouhi G,Tubbs RS,Shoja MM,Roshangar L,Mesgari M,Ghorbanihaghjo A,Ahmadi N,Sheikhzadeh F,Rad JS

更新日期：2008-04-09 00:00:00

abstract：:Uptake of 131iodine-metaiodobenzylguanidine (131I-MIBG) by 6-23 rat medullary thyroid carcinoma (MTC), was studied in vitro and in vivo. In vitro, there was an 8-fold increase in 131I uptake by 6-23 cells when labeled with 131I-MIBG (131I 24 +/- 15 cpm/10(6) cells, 131I-MIBG 196 +/- 9 cpm/10(6) cells). MIBG uptake in ...

journal_title：Life sciences

authors： Poston GJ,Fawcett HD,Townsend CM Jr,James E,Lieg JL,Nusynowitz ML,Thompson JC

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a severe public health problem around the globe. Various epidemiological, statistical, and laboratory-based studies have shown that the role of temperature and other environmental factors has important influence in the transmission of coronaviruses. Scientific r...

journal_title：Life sciences

authors： Fawad M,Mubarik S,Malik SS,Ren J

更新日期：2021-01-18 00:00:00

abstract：:Dopamine receptors in human parathyroid were studied in vitro using ligand binding techniques. With 3H-piflutixol as ligand, binding characteristic of the dopamine D1 receptor was observed. Administration of apomorphine, flupenthixol or metoclopramide to normal controls or acute schizophrenic patients at doses produci...

journal_title：Life sciences

authors： Cross AJ,Ferrier IN,Bloxham CA

更新日期：1983-08-22 00:00:00