Abstract：
:This work explored cellular trapping and extrusion of Cd and Hg in epithelial cells, with special emphasis on the jejunal mucosa. Important determinants of these processes are the concentration, diffusibility and relative metal affinities of a variety of cellular metal-binding compounds including metallothionein (MT). As predicted from the known properties of MT, this protein can compete with other sulfhydryl compounds for Cd but not for Hg; this is illustrated by the observation that glutathione (GSH) stimulates extrusion of only Hg. Similar factors can help explain why, in spite of its tighter binding by MT, Hg has a shorter biological half-life in renal cortex than does Cd. Metal extrusion from cells presumably involves movement of diffusible complexes such as HgGSH.
journal_name
Life Scijournal_title
Life sciencesauthors
Foulkes ECdoi
10.1016/0024-3205(93)90042-2subject
Has Abstractpub_date
1993-01-01 00:00:00pages
1617-20issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(93)90042-2journal_volume
52pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:T cell receptor (TCR/CD3) induced fluctuations in intracellular free ionizied calcium, [Ca2+]i, was analysed in the human T leukemia cell clone, Jurkat, cultured in the presence of the opioid methionine enkephalinamide (Met-Enk) in titrated concentrations (10[-7] to 10[-15] M) or saline (PBS). In the majority of indiv...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00055-1
更新日期：1998-01-01 00:00:00
abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90626-1
更新日期：1988-01-01 00:00:00
abstract：AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117814
更新日期：2020-08-15 00:00:00
abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.119009
更新日期：2021-01-04 00:00:00
abstract：:Insulin remains a predominant life-saving medication for type 1 and type 2 Diabetes Mellites. Natural insulin secretion limits the fluctuation of the narrow and high surge of blood glucose levels. However, imitating the same by external insulin remains a challenge as a variety of insulin analogs (rapid acting, short a...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.01.011
更新日期：2019-02-15 00:00:00
abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.004
更新日期：2006-07-04 00:00:00
abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.11.002
更新日期：2017-01-01 00:00:00
abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90392-3
更新日期：1992-01-01 00:00:00
abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90593-z
更新日期：1991-01-01 00:00:00
abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.11.003
更新日期：2010-01-02 00:00:00
abstract：:It has been previously shown in anesthetized pigs that intravenous infusion of 2 microg/h of 17beta-estradiol primarily dilated renal, iliac and coronary circulations, while higher doses of the hormone were required to cause vasodilation also in the mesenteric vascular bed. In the same experimental model, a tonic beta...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00399-9
更新日期：1999-01-01 00:00:00
abstract：:The microscopic localization of angiotensin II receptors in the rat brainstem has been accomplished utilizing in vitro receptor autoradiographic techniques. These receptors are highly localized to discrete nuclear regions of the brainstem. Significant densities of autoradiographic grains, indicating the presence of sp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90611-8
更新日期：1984-04-16 00:00:00
abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.12.015
更新日期：2017-03-01 00:00:00
abstract：AIMS:This study aimed to design and screen a dual functional fusion peptide that could penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular endothelial cells for the anti-angiogenesis of glioma treatment. MAIN METHODS:At the cellular level, the in vitro anti-angiogenic activity of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119113
更新日期：2021-01-27 00:00:00
abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90367-x
更新日期：1986-09-08 00:00:00
abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90316-4
更新日期：1991-01-01 00:00:00
abstract：:Effects of ethanol in vitro on membrane vesicles (microsacs prepared from mouse cerebral cortex) were evaluated by monitoring 36Cl- influx. Different assay parameters were tested to determine increased or decreased action of ethanol on GABA-activated chloride channels. The ability of 30 mM ethanol to augment 36Cl- flu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90009-g
更新日期：1990-01-01 00:00:00
abstract：:In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01214-0
更新日期：2001-08-03 00:00:00
abstract：:Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90216-x
更新日期：1986-06-09 00:00:00
abstract：:The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.04.005
更新日期：2007-05-16 00:00:00
abstract：:The effects of t-butylhydroperoxide (TBH) and cigarette smoke on lung mechanics (CDYN and RL) and glutathione status (GSH) were studied using an isolated perfused and ventilated rat lung preparation. TBH (200, 400, 1000 microM) infused via the pulmonary circulation caused a dose-related bronchoconstriction. The lung G...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90054-9
更新日期：1988-01-01 00:00:00
abstract：:[3H]A-69024 has been prepared as a radioligand for studying the dopamine D1 receptor. [3H]A-69024 binds to rat striatal membranes with a KD = 14.3 +/- 3.2 nM (mean +/- SEM; n = 3) and Bmax = 63.5 +/- 12.8 fmol/mg wet tissue (1.8 +/- 0.3 pmol/mg protein). This ligand binds to only one site with a Hill coefficient close...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02212-2
更新日期：1995-01-01 00:00:00
abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90786-5
更新日期：1983-08-22 00:00:00
abstract：:Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more freque...
journal_title：Life sciences
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90394-5
更新日期：1992-01-01 00:00:00
abstract：:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90338-1
更新日期：1982-09-20 00:00:00
abstract：:This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.03.011
更新日期：2004-08-06 00:00:00
abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90549-1
更新日期：1985-08-26 00:00:00
abstract：AIMS:Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.08.032
更新日期：2017-11-15 00:00:00
abstract：:Specific binding sites for atrial natriuretic peptide (ANP) were identified and characterized in primary cultures of human thyroid cells. Saturation analysis using [125I] alpha rat ANP as the ligand showed a single class of high affinity binding (Kd = 0.2 nM) which was inhibited by atriopeptin I and the alpha -human f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90172-0
更新日期：1989-01-01 00:00:00
