Abstract：
:This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts were detected in lower abundance in this tissue. alpha1a-adrenoceptor mRNA expression presented a complex dependency on androgens, while alpha1b- and alpha1d-adrenoceptor transcripts were both upregulated with surgical and chemical castration, suggesting a negative modulation by androgens. Testosterone treatment reversed the effects caused by surgical castration. Functional studies confirmed the involvement of alpha1A- and alpha1B-adrenoceptor in the seminal vesicle contractile responses, and suggested that alpha1B-induced contractile response was upregulated after castration. Taken together, the results suggest that alpha1-adrenoceptor expression in seminal vesicle is differentially regulated by the androgen status of the rat.
journal_name
Life Scijournal_title
Life sciencesauthors
Mendes FR,Hamamura M,Queiróz DB,Porto CS,Avellar MCdoi
10.1016/j.lfs.2004.03.011subject
Has Abstractpub_date
2004-08-06 00:00:00pages
1449-63issue
12eissn
0024-3205issn
1879-0631pii
S0024320504004424journal_volume
75pub_type
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