SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.

abstract：AIMS:Bisphenol (BP)-A exposure can impair glucose and lipid metabolism. However, it is unclear whether this endocrine disruptor (ED) modulates these processes in postmenopause, a period with organic changes that increase the risk for metabolic diseases. Herein, we evaluated the effects of BPA exposure on adiposity, glu...

journal_title：Life sciences

authors： Figueiredo LS,Oliveira KM,Freitas IN,Silva JA Jr,Silva JN,Favero-Santos BC,Bonfleur ML,Carneiro EM,Ribeiro RA

更新日期：2020-09-01 00:00:00

abstract：:TCDD was assessed as a biological response modifier for increasing MMC cytotoxicity through aryl hydrocarbon receptor (AhR) activation and increasing levels of bioreductive enzymes. Human MCF-7 cells were exposed to TCDD, MMC and combinations thereof under aerobic or hypoxic conditions. Cytotoxicity, enzyme activities...

journal_title：Life sciences

authors： Collier AC,Pritsos KL,Pritsos CA

更新日期：2006-02-23 00:00:00

abstract：:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...

journal_title：Life sciences

authors： Aft RL,Mueller GC

更新日期：1985-06-03 00:00:00

abstract：:Maintenance of the cellular calcium homeostasis plays an important role for neuronal cell function and interneuronal cell to cell communication. Therefore, alterations of the neuronal Ca2+ homeostasis may play a crucial role for brain aging in general and for age-related deficits in cognitive functions particularly. N...

journal_title：Life sciences

authors： Hartmann H,Eckert A,Müller WE

更新日期：1994-01-01 00:00:00

abstract：:Resting pituitary levels of beta-endorphin-(beta-EP-IR), ACTH-(ACTH-IR), and alpha-MSH-(alpha-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependenc...

journal_title：Life sciences

authors： Crabbe JC,Keith LD,Kosobud A,Stack J

更新日期：1983-11-07 00:00:00

abstract：:The purpose of this study is to report the development of a non-radioactive fluorescent peptide assay for measuring protein kinase C activity (PKC). The assay is based on a glycogen synthase derived fluorescent peptide that is phosphorylated by PKC. Phosphorylation causes the peptide to migrate toward the anode while ...

journal_title：Life sciences

authors： Isbell JC,Christian ST,Mashburn NA,Bell PD

更新日期：1995-01-01 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:In our previous paper (Biochem. Biophys. Res. Commun. 141, 20-26 (1986) we reported the isolation of a 34000-dalton protein (p34K) which binds to calmodulin and F-actin from chicken gizzard smooth muscle. We examined the distribution of the immunoreactive component of gizzard p34K in bovine tissues by immunoblot analy...

journal_title：Life sciences

authors： Takahashi K,Hiwada K,Kokubu T

更新日期：1987-07-20 00:00:00

abstract：AIMS:To characterize the effects of a calorie matched high-fat diet (HFD) on spontaneous physical activity (SPA), body weight, inflammatory status and expression of genes related to energy homeostasis in hypothalamus of mice. MAIN METHODS:C57Bl/6 mice (n=5 per group) were fed a control diet (16.5% calories from fat) -...

journal_title：Life sciences

authors： Moretto TL,Benfato ID,de Carvalho FP,Barthichoto M,Le Sueur-Maluf L,de Oliveira CAM

更新日期：2017-06-15 00:00:00

abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...

journal_title：Life sciences

authors： Zhong J,Guo C,Hou W,Shen N,Miao C

更新日期：2019-10-15 00:00:00

abstract：:Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...

journal_title：Life sciences

authors： Crook JM,Dean B,Pavey G,Copolov D

更新日期：1999-01-01 00:00:00

abstract：:To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...

journal_title：Life sciences

authors： Ito I,Minegishi T,Hasegawa Y,Shinozaki H,Nakamura K,Igarashi S,Nakamura M,Miyamoto K,Ibuki Y

更新日期：1993-01-01 00:00:00

abstract：:Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effe...

journal_title：Life sciences

authors： Jiang N,Lv J,Wang H,Huang H,Wang Q,Lu C,Zeng G,Liu XM

更新日期：2020-07-01 00:00:00

abstract：:A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological c...

journal_title：Life sciences

authors： Cotecchia S,De Blasi A

更新日期：1984-12-03 00:00:00

abstract：:The aims of the current study were: 1) to determine if the epsilonPKC pseudosubstrate peptide (epsilonphi) (NH(2)-RKRQGAVRRRVHQVNG-COOH) could be used as an epsilonPKC-selective inhibitor in neonatal cardiac myocytes (NCMs) and 2) to determine if differences in the alpha and epsilonPKC autoinhibitory pseudosubstrate m...

journal_title：Life sciences

authors： Johnson JA

更新日期：2004-05-07 00:00:00

abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

journal_title：Life sciences

authors： Ono T,Iijima M,Shinoda S,Wada O

更新日期：1997-01-01 00:00:00

abstract：:In saturation binding experiments, (+)pentazocine, (+)3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP), haloperidol and rimcazole did not inhibit the binding of [3H]DTG in a purely competitive fashion. Although Scatchard analysis indicated that [3H]DTG bound to a single site, the inhibition curves of some, but not all, ...

journal_title：Life sciences

authors： DeHaven-Hudkins DL,Fleissner LC

更新日期：1992-01-01 00:00:00

abstract：:In order to assess the relative cytokine contribution to endotoxin stimulation of pituitary-adrenocortical hormone secretion, we measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF alpha), adrenocorticotropin (ACTH) and corticosterone following lipopolysaccharide (LPS) challenge in rats....

journal_title：Life sciences

authors： Takao T,Nanamiya W,Takemura T,Nishiyama M,Asaba K,Makino S,Hashimoto K,De Souza EB

更新日期：1997-01-01 00:00:00

abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

journal_title：Life sciences

authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

更新日期：1991-01-01 00:00:00

abstract：:The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...

journal_title：Life sciences

authors： de Araújo DA,Freitas C,Cruz JS

更新日期：2011-10-10 00:00:00

abstract：:Endogenous dopamine (DA) and norepinephrine (NE) in the superfusate from slices of rat medial prefrontal cortex were measured by high-performance liquid chromatography coupled to electrochemical detection (HPLC-ECD). Stimulation with high K+ or methamphetamine (MAP) evoked a dose-dependent elevation in the release of ...

journal_title：Life sciences

authors： Ohmori T,Koyama T,Yamashita I

更新日期：1991-01-01 00:00:00

abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

journal_title：Life sciences

authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

更新日期：1987-05-25 00:00:00

abstract：AIMS:Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the ...

journal_title：Life sciences

authors： Jesmin S,Shimojo N,Yamaguchi N,Mowa CN,Oki M,Zaedi S,Sultana SN,Rahman A,Islam M,Sawamura A,Gando S,Kawano S,Miyauchi T,Mizutani T

更新日期：2014-05-02 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of thyrotropin-releasing hormone (TRH) in a range from 0.1 to 100 micrograms induced a dose-related increase in blood pressure in conscious rats, whereas TRH-free acid (TRH-OH) and histidyl-proline diketopiperazine (His-Pro-DKP), metabolites of TRH, did not. The blood pr...

journal_title：Life sciences

authors： Okuda C,Mizobe T,Miyazaki M

更新日期：1987-03-30 00:00:00

abstract：:This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...

journal_title：Life sciences

authors： Iwamoto LM,Wilson VL,Lavallee SL,Fujiwara N,Ayau EL,Nakamura KT

更新日期：1996-01-01 00:00:00

abstract：:To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a holding potential of ...

journal_title：Life sciences

authors： Ma B,Yu LH,Fan J,Ni X,Burnstock G

更新日期：2008-08-01 00:00:00

abstract：:An experimental model which resembles human drug addiction was developed to study the effect of chronic drug (cocaine or morphine) administration on the immune system. As malnutrition has been associated with drug use, a low protein diet has been evaluated for its contribution to the impairment of the immune system du...

journal_title：Life sciences

authors： Lopez MC,Huang DS,Watzl B,Chen GJ,Watson RR

更新日期：1991-01-01 00:00:00

abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...

journal_title：Life sciences

authors： Chatterjee S,Johnson DC

更新日期：1993-01-01 00:00:00

abstract：:This study was designed to determine whether the increase in atriopeptin secretion induced by an intravenous infusion of norepinephrine is mediated directly by adrenergic receptor stimulation or indirectly by the associated increase in atrial pressure. Norepinephrine was infused at 0.5 microgram.kg-1.min-1 for 30 min ...

journal_title：Life sciences

authors： Zhu JL,Leadley RJ Jr,Geer PG,Wang BC,Goetz KL

更新日期：1990-01-01 00:00:00

abstract：:Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1998-01-01 00:00:00