Abstract:
:Resting pituitary levels of beta-endorphin-(beta-EP-IR), ACTH-(ACTH-IR), and alpha-MSH-(alpha-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary beta-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary beta-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.
journal_name
Life Scijournal_title
Life sciencesauthors
Crabbe JC,Keith LD,Kosobud A,Stack Jdoi
10.1016/0024-3205(83)90672-0subject
Has Abstractpub_date
1983-11-07 00:00:00pages
1877-87issue
19eissn
0024-3205issn
1879-0631pii
0024-3205(83)90672-0journal_volume
33pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90429-u
更新日期:1990-01-01 00:00:00
abstract:AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.08.033
更新日期:2012-10-29 00:00:00
abstract::A phencyclidine (PCP) receptor binding site has been solubilized in an active ligand-binding state from rat cerebral cortical membranes with sodium deoxycholate. Optimal receptor solubilization occurs at a detergent/protein ratio of 0.5 (w/w); for 5 mg protein/ml solubilized with 0.25% sodium deoxycholate, about 60% o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90567-5
更新日期:1989-01-01 00:00:00
abstract::Cognitive function of rats treated with saline (control), THA (8 mg/kg, i.p.), scopolamine (5 mg/kg, i.p.), or a combination of THA (8 mg/kg) and scopolamine (5 mg/kg) was tested in the Morris water maze. The latency to find the platform in the water maze was used to evaluate performance. THA did not significantly alt...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02254-6
更新日期:1996-01-01 00:00:00
abstract::A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90047-9
更新日期:1982-10-11 00:00:00
abstract::In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90651-x
更新日期:1986-07-28 00:00:00
abstract:AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118402
更新日期:2020-11-15 00:00:00
abstract::This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00120-6
更新日期:2003-04-11 00:00:00
abstract::Serotonin (5HT) stimulates phosphoinositide turnover in a number of tissues, but it is not known whether this effect is due to activation of a 5HT receptor which is coupled to phosphoinositide hydrolysis or if the effect is secondary to 5HT stimulated arachidonate metabolism or to the release of another neurotransmitt...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90060-3
更新日期:1986-02-17 00:00:00
abstract:AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.01.008
更新日期:2014-11-24 00:00:00
abstract::Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2015.01.006
更新日期:2015-04-01 00:00:00
abstract::To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90260-8
更新日期:1987-02-16 00:00:00
abstract::The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90357-u
更新日期:1992-01-01 00:00:00
abstract:AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.01.010
更新日期:2013-03-14 00:00:00
abstract:AIMS:Asiaticoside (AS) is a saponin monomer extracted from the medicinal plant Centella asiatica, which has a variety of biological effects. We intended to investigate the effects of asiaticoside on a hypoxia-induced pulmonary hypertension (HPH) rat model and examine the possible effects of asiaticoside on TGF-β1/Smad ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.07.016
更新日期:2015-09-15 00:00:00
abstract::Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(82)90643-9
更新日期:1982-01-11 00:00:00
abstract::Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.032
更新日期:2007-11-30 00:00:00
abstract::Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00107-0
更新日期:1997-01-01 00:00:00
abstract::Several different vasodilator substances can be released by vascular endothelium in response to mechanical stimuli and vasoactive agents. The purpose of this study was to determine whether there is a male-female difference in the relative contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing facto...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01851-9
更新日期:2002-08-23 00:00:00
abstract:AIMS:To investigate the therapeutic effects of human amniotic mesenchymal stem cells (hAMSCs) on paraquat (PQ)-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. MAIN METHODS:hAMSCs were identified by morphological, flow cytometry and immunocytochemistry. A pulmonary fibrosis model was ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117290
更新日期:2020-02-15 00:00:00
abstract::As a step in the purification and characterization of the glucose transporter from rat skeletal muscle, we have reconstituted glucose transport activity in liposomes. Plasma membranes were prepared from skeletal muscle which display D-glucose reversible binding of cytochalasin B (10 pmol sites/mg protein; KD = 0.3 mic...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90503-0
更新日期:1987-06-15 00:00:00
abstract::Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90312-1
更新日期:1985-06-03 00:00:00
abstract::In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0.75 mg and intravenous clonidine 2 mcg/kg on CO2-induced increases in ratings of subjective anxiety, pulse rate, and ventilation were measured in healthy human subjects. Pretreatment wit...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90255-5
更新日期:1989-01-01 00:00:00
abstract::Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90210-7
更新日期:1982-10-18 00:00:00
abstract:AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118391
更新日期:2020-10-15 00:00:00
abstract::The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.12.010
更新日期:2018-02-01 00:00:00
abstract::Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90347-2
更新日期:1982-09-20 00:00:00
abstract::Metalloproteinases (MMP), particularly MMP-9 produced by the intratumor monocyte/macrophages, play an important role in tumor invasion and metastases. Recent clinical trials in patients with primary breast cancer suggest that bisphosphonates (BP), above all clodronate, may reduce bone metastases. The aim of the presen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00657-x
更新日期:2003-09-26 00:00:00
abstract:UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90261-z
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of lipoxin A4 (LXA4) on inflammatory responses in obesity-related glomerulopathy (ORG) mouse model and its potential mechanisms. METHODS:Male C57BL/6 mice were randomly divided into 4 groups: normal, model, LXA4, and LXA4/Boc-2 groups (n = 8). Mice in LXA4 group were intraperitone...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.02.039
更新日期:2018-04-01 00:00:00