Melatonin effect on serotonin uptake and release in rat platelets: diurnal variation in responsiveness.

abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...

journal_title：Life sciences

authors： Ding YX,Shi Y,Han WJ,Cui H

更新日期：2016-04-01 00:00:00

abstract：UNLABELLED:Acute exercise is a stress stimulus that may cause cell damage through the activation of the toll-like receptor (TLR)4 pathway, resulting in the translocation of nuclear factor kappa B (NF-κB) into the cell nucleus and the upregulation of inflammatory genes. Nonsteroidal anti-inflammatory drugs, such as dicl...

journal_title：Life sciences

authors： Barcelos RP,Bresciani G,Rodriguez-Miguelez P,Cuevas MJ,Soares FA,Barbosa NV,González-Gallego J

更新日期：2016-03-01 00:00:00

abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...

journal_title：Life sciences

authors： Flint RS,McBride WJ

更新日期：1986-01-20 00:00:00

abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

journal_title：Life sciences

authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

更新日期：1998-01-01 00:00:00

abstract：:Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At AT1 receptors of the rabbit aorta, A-81282 exhibited a pA2 of 9.64 (+/- 0.33) vs. angiotensin-II, and demonstrated characteristics consistent with competitive an...

journal_title：Life sciences

authors： Hancock AA,Buckner SA,Lee JY,Brune M,Morse PA,Oheim K,Warner RB,Winn M,Zydowsky TM,De B

更新日期：1993-01-01 00:00:00

abstract：:An increased level of melanin is characteristic of a large number of skin diseases, including acquired hyperpigmentation conditions such as melasma, post inflammatory melanoderma, and solar lentigo. Thus, there is an increasing need for the development of depigmenting agents. In order to evaluate the depigmenting capa...

journal_title：Life sciences

authors： Lee J,Jung K,Kim YS,Park D

更新日期：2007-06-27 00:00:00

abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...

journal_title：Life sciences

authors： Mazurkiewicz-Kwilecki IM

更新日期：1983-03-07 00:00:00

abstract：:The effects of adenosine on the amylase secretion from rat pancreatic lobules have been studied. Adenosine induces a dose-dependent stimulation on amylase release, which is maximal at a concentration of 10(-4) M. It has been observed a clear inhibition of this secretory action when atropine was added whereas no amylas...

journal_title：Life sciences

authors： Rodríguez-Nodal F,San Román JI,López-Novoa JM,Calvo JJ

更新日期：1995-01-01 00:00:00

abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

journal_title：Life sciences

authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

更新日期：1985-03-18 00:00:00

abstract：:Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration...

journal_title：Life sciences

authors： Kirby AW,Harding TH,Wiley RW

更新日期：1987-12-14 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

journal_title：Life sciences

authors： Dufy B,Barker JL

更新日期：1982-05-31 00:00:00

abstract：:Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressu...

journal_title：Life sciences

authors： Ames JR,Ryan MD,Kovacic P

更新日期：1987-10-19 00:00:00

abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

journal_title：Life sciences

authors： Yasmineh WG,Tsai MY,Theologides A

更新日期：1995-01-01 00:00:00

abstract：AIMS:We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response. MAIN METHODS:The pathophysiological changes induced by a lack of both α2-AP and PA...

journal_title：Life sciences

authors： Okada K,Ueshima S,Kawao N,Yano M,Tamura Y,Tanaka M,Sakamoto A,Hatano M,Arima M,Miyata S,Nagai N,Tokuhisa T,Matsuo O

更新日期：2013-07-30 00:00:00

abstract：:The cytokeratins from human bladder and esophageal epithelia were separated using chromatographic techniques. The cytokeratins were first extracted from fresh autopsy tissue using high and low salt buffers. Urea, 8.0-9.5 M, was used to solubilize the resulting cytokeratin pellet. Imidazole was found to increase the so...

journal_title：Life sciences

authors： Meiklejohn B,Nagle RB,McDaniel KM,Wilson GS

更新日期：1990-01-01 00:00:00

abstract：:The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...

journal_title：Life sciences

authors： Coussons-Read ME,Daniels M,Gilmour MI

更新日期：1999-01-01 00:00:00

abstract：:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...

journal_title：Life sciences

authors： Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park R

更新日期：2002-10-04 00:00:00

abstract：:14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-reti...

journal_title：Life sciences

authors： Rühl R,Hamscher G,Garcia AL,Nau H,Schweigert FJ

更新日期：2005-02-18 00:00:00

abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...

journal_title：Life sciences

authors： Cha JH,Dure LS 4th

更新日期：1994-01-01 00:00:00

abstract：AIMS:Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and m...

journal_title：Life sciences

authors： Gergerlioglu HS,Oz M,Demir EA,Nurullahoglu-Atalik KE,Yerlikaya FH

更新日期：2016-03-01 00:00:00

abstract：:Bacitracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is...

journal_title：Life sciences

authors： deBlois D,Bouthillier J,Marceau F

更新日期：1990-01-01 00:00:00

abstract：:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...

journal_title：Life sciences

authors： Haigler HJ,Cahill LF,Crager MR,Charles E

更新日期：1987-01-12 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:Linoleic acid (LA) (n-6) and α-linolenic acid (ALA) (n-3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3) that pla...

journal_title：Life sciences

authors： Saini RK,Keum YS

更新日期：2018-06-15 00:00:00

abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...

journal_title：Life sciences

authors： El Golli N,Dkhili H,Dallagi Y,Rahali D,Lasram M,Bini-Dhouib I,Lebret M,Rosa JP,El Fazaa S,Allal-El Asmi M

更新日期：2016-02-01 00:00:00

abstract：AIMS:Studies have associated obesity with a wide variety of cancers. Metformin, an anti-diabetic drug, has recently received attention as a potentially useful therapeutic agent for treating cancer. Therefore, the objective of this study was to analyze the mechanisms involved in the increase in tumor development and the...

journal_title：Life sciences

authors： de Queiroz EA,Akamine EH,de Carvalho MH,Sampaio SC,Fortes ZB

更新日期：2015-01-15 00:00:00

abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...

journal_title：Life sciences

authors： Weinberger SE,Steinbrook RA,Carr DB,Fencl V,Gabel RA,Leith DE,Fisher JE,Harris R,Rosenblatt M

更新日期：1987-02-16 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00