Hepatic mitochondrial enzyme activity and serum amino acid composition in rats treated with tumor necrosis factor.

abstract：:The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a po...

journal_title：Life sciences

authors： Ben V,Bruguerolle B

更新日期：2000-08-18 00:00:00

abstract：AIMS:Thrombin is a serine proteinase that is not only involved in coagulation cascade, but also mediates a number of biological responses relevant to tissues repair, and induces bronchoconstriction. TGF-β plays a pivotal role in airway remodeling due to its effects on airway smooth muscle proliferation and extracellula...

journal_title：Life sciences

authors： Yao ZH,Xie HJ,Yuan YL,Huo YT,Cao J,Lai WY,Cai RJ,Cheng YX

更新日期：2018-03-15 00:00:00

abstract：AIMS:Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found. Levosimendan demonstrated neuroprotective effects and reduced mortality...

journal_title：Life sciences

authors： Gooshe M,Tabaeizadeh M,Aleyasin AR,Mojahedi P,Ghasemi K,Yousefi F,Vafaei A,Amini-Khoei H,Amiri S,Dehpour AR

更新日期：2017-01-01 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：:ACE and chymase play crucial roles in the establishment of pressure overload-induced cardiac hypertrophy. In the present study, time sequences of ACE and chymase-like activities, and their correlation with hypertrophic changes including free wall thickness and cardiac fibrosis, were elucidated in dogs with constant pr...

journal_title：Life sciences

authors： Orito K,Yamane T,Kanai T,Fujii Y,Wakao Y,Matsuda H

更新日期：2004-07-16 00:00:00

abstract：AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...

journal_title：Life sciences

authors： Wan L,Tan N,Zhang N,Xie X

更新日期：2020-11-15 00:00:00

abstract：:Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...

journal_title：Life sciences

authors： Soltani N,Keshavarz M,Sohanaki H,Dehpour AR,Zahedi Asl S

更新日期：2005-02-11 00:00:00

abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...

journal_title：Life sciences

authors： Magnan E,Cataldi M,Guillaume V,Conte-Devolx B,Graziani N,Figaroli JC,Thomas F,Chihara K,Oliver C

更新日期：1992-01-01 00:00:00

abstract：:Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...

journal_title：Life sciences

authors： Cirino G,Misasi M,Loffredo A,Sorrentino L,Caivano P,Bucci M,Cicala C

更新日期：1996-01-01 00:00:00

abstract：:The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...

journal_title：Life sciences

authors： Avent KM,Riker RR,Fraser GL,Van der Schyf CJ,Usuki E,Pond SM

更新日期：1997-01-01 00:00:00

abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...

journal_title：Life sciences

authors： Irvine RJ,White JM,Head RJ

更新日期：1995-02-17 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...

journal_title：Life sciences

authors： Desiderio DM,Cezayirli RC,Fridland G,Robertson JT,Sacks H

更新日期：1985-11-11 00:00:00

abstract：:Evidence for a drug-induced activation of central sigma systems is presented. The model is the locomotor activation initiated by a subcutaneous (SC) challenge of 1.6 mg/kg of (+)-butaclamol, (+)-BUT, given 30 min before 10 mg/kg SC of (-)-N-allylnormetazocine, (-)-NAN, in Sprague-Dawley male rats which have been pretr...

journal_title：Life sciences

authors： Iwamoto ET

更新日期：1989-01-01 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:We investigated the effects of genistein and genistin on proliferation and apoptosis of human ovarian SK-OV-3 cells and explored the mechanism for these effects. SK-OV-3 cells were treated with genistein and genistin at various concentrations (ranging from 1 to 100 muM) either alone or in combination for 24 and 48 h. ...

journal_title：Life sciences

authors： Choi EJ,Kim T,Lee MS

更新日期：2007-03-20 00:00:00

abstract：:Uncoupling proteins (UCPs) are supposed to be involved in diet-induced thermogenesis. Their activities are usually elevated by feeding and reduced by fasting in normal animals. To investigate whether fasting affects the expression of UCPs mRNA in brown adipose tissue (BAT) of bilateral ventromedial hypothalamus (VMH)-...

journal_title：Life sciences

authors： Kageyama H,Osaka T,Kageyama A,Kawada T,Hirano T,Oka J,Miura M,Namba Y,Ricquier D,Shioda S,Inoue S

更新日期：2003-05-16 00:00:00

abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

journal_title：Life sciences

authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

更新日期：2012-09-24 00:00:00

abstract：:Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...

journal_title：Life sciences

authors： Yue KK,Chung WS,Leung AW,Cheng CH

更新日期：2003-10-03 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：:The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...

journal_title：Life sciences

authors： Gulati A,Rebello S,Chari G,Bhat R

更新日期：1992-01-01 00:00:00

abstract：:Cold acclimation increases the thermogenic capacity of brown adipose tissue (BAT) and this is associated with both a general hypertrophy of the tissue and a selective increase in the proportion of a specific 32,000 molecular weight, GDP-binding protein in the mitochondrial membrane. This protein regulates the activity...

journal_title：Life sciences

authors： Young P,Wilson S,Arch JR

更新日期：1984-03-19 00:00:00

abstract：AIMS:Steroid hormones and steroid receptors (SRs) play a crucial role in spermatogenesis. Steroid receptor coregulators are the major determinants of SR functioning, and any alteration in their expression is known to be associated with impaired spermatogenesis. Since Bisphenol A (BPA) exposure leads to an impairment of...

journal_title：Life sciences

authors： Salian S,Doshi T,Vanage G

更新日期：2009-07-03 00:00:00

abstract：AIMS:We tested the hypothesis that respiratory quotient (RQ) determines sympathovagal balance associated with metabolism of stored and dietary energy substrates. MAIN METHODS:Six 18-20 year-old African-American males were studied after two control pretreatments of fasting and post-treatments of metabolizing high-fat a...

journal_title：Life sciences

authors： Millis RM,Austin RE,Bond V,Faruque M,Goring KL,Hickey BM,Blakely R,Demeersman RE

更新日期：2009-07-17 00:00:00

abstract：AIMS:Centella asiatica has been used to treat kidney diseases in Chinese traditional medicine. Asiaticoside (an extraction of C. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. However, the mechanism of asiaticoside in the treatment of renal diseases rem...

journal_title：Life sciences

authors： Wang Z,Liu J,Sun W

更新日期：2013-09-03 00:00:00

abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...

journal_title：Life sciences

authors： Chen J,Tan L,Liao Y,Long J,Zhou Y,Wei J,Zhou Y

更新日期：2020-08-15 00:00:00

abstract：:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lo...

journal_title：Life sciences

authors： Reid LD,Konecka AM,Przewłocki R,Millan MH,Millan MJ,Herz A

更新日期：1982-10-18 00:00:00

abstract：:Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin alpha, which is a member of the thymic hormone family, has recently been suggested to act as a nuc...

journal_title：Life sciences

authors： Wu CL,Shiau AL,Lin CS

更新日期：1997-01-01 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00