Mode of action of antiprotozoan agents. Electron transfer and oxy radicals.

abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

journal_title：Life sciences

authors： Nath M,Bhattacharjee K,Choudhury Y

更新日期：2021-02-01 00:00:00

abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...

journal_title：Life sciences

authors： Gambacciani M,Yen SS,Rasmussen DD

更新日期：1988-01-01 00:00:00

abstract：:Orthodontic tooth movement induced alveolar bone resorption and formation around the teeth applied mechanical force. Although mechanical force can promote bone formation, the molecular mechanism that underlies this phenomenon is not fully understood. The purposes of this study were to determine how mechanical stress a...

journal_title：Life sciences

authors： Mitsui N,Suzuki N,Maeno M,Yanagisawa M,Koyama Y,Otsuka K,Shimizu N

更新日期：2006-05-01 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00

abstract：:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephr...

journal_title：Life sciences

authors： Johnson MD

更新日期：1987-10-19 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...

journal_title：Life sciences

authors： Mouton AJ,El Hajj EC,Ninh VK,Siggins RW,Gardner JD

更新日期：2020-03-15 00:00:00

abstract：:We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...

journal_title：Life sciences

authors： Besret L,Dauphin F,Guillouet S,Dhilly M,Gourand F,Blaizot X,Young AR,Petit-Taboué MC,Mickala P,Barbelivien A,Rault S,Barré L,Baron JC

更新日期：1998-01-01 00:00:00

abstract：:The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...

journal_title：Life sciences

authors： Pickworth WB,Bunker E,Welch P,Cone E

更新日期：1991-01-01 00:00:00

abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...

journal_title：Life sciences

authors： Hale CC,Rovetto MJ

更新日期：1995-01-01 00:00:00

abstract：:The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, I have shown that myricetin exhibits a significant induction of different...

journal_title：Life sciences

authors： Kuo PL

更新日期：2005-10-21 00:00:00

abstract：:Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful trea...

journal_title：Life sciences

authors： Suranyi-Cadotte BE,Quirion R,Nair NP,Lafaille F,Schwartz G

更新日期：1985-02-25 00:00:00

abstract：AIMS:Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the ...

journal_title：Life sciences

authors： Jesmin S,Shimojo N,Yamaguchi N,Mowa CN,Oki M,Zaedi S,Sultana SN,Rahman A,Islam M,Sawamura A,Gando S,Kawano S,Miyauchi T,Mizutani T

更新日期：2014-05-02 00:00:00

abstract：AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...

journal_title：Life sciences

authors： Liu G,Xie C,Fang Y,Qian K,Liu Q,Liu G,Cao Z,Du H,Fu J,Xu X

更新日期：2018-01-01 00:00:00

abstract：:Current therapy for type 1 diabetes mellitus involves a daily regimen of multiple subcutaneous or intramuscular injections of recombinant human insulin. To achieve long-term insulin delivery in vivo, we investigated the applicability of cytomedical therapy using beta TC6 cells or MIN6 cells, both of which are murine p...

journal_title：Life sciences

authors： Suzuki R,Okada N,Miyamoto H,Yoshioka T,Sakamoto K,Oka H,Tsutsumi Y,Nakagawa S,Miyazaki J,Mayumi T

更新日期：2002-08-30 00:00:00

abstract：:A question whether phosphorylation is involved in adrenergic effects on cardiac tissues has long been a matter of dispute. We examined whether phosphorylation is involved in adrenergic chronotropism and inotropism in excised cardiac muscles from guinea pigs. KT5720, a specific inhibitor of A-kinase, abolished the late...

journal_title：Life sciences

authors： Gotoh H

更新日期：1995-01-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

journal_title：Life sciences

authors： Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

更新日期：2021-01-27 00:00:00

abstract：:In a guinea-pig model of asthma, active immunization against substance P (SP) prevented the development of airways' hyperresponsiveness and reduced bronchospastic responses to SP (i.v.). The rat-mouse heterohybridoma NC1/34 secretes a specific, rat IgG1, anti-substance P antibody (alpha-SP Ab) which was isolated and p...

journal_title：Life sciences

authors： Jafarian A,Suresh MR,Kreutz FT,Biggs DF

更新日期：1995-01-01 00:00:00

abstract：AIMS:The study investigated the antidepressant-like effect and acute toxicity of 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole (Se-TZ), an organoselenium-containing heterocycle compound in mice. MAIN METHODS:The antidepressant-like effect of Se-TZ (1-50mg/kg) and its mechanism of action, was analyzed in the tail sus...

journal_title：Life sciences

authors： Donato F,de Gomes MG,Goes AT,Seus N,Alves D,Jesse CR,Savegnago L

更新日期：2013-09-17 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:Growth-related oncogene protein-alpha (GRO-alpha) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-alpha by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor alpha (sIL-6R). s...

journal_title：Life sciences

authors： Matsumiya T,Imaizumi T,Itaya H,Shibata T,Yoshida H,Sakaki H,Kimura H,Satoh K

更新日期：2002-05-17 00:00:00

abstract：:Since hypertension may compromise the ability to withstand hypernatremic dehydration, we investigated the impact of two experimental models of hypertension and pharmacologic normalization of blood pressure on the tolerance to chronic hypernatremic dehydration. In DOCA-salt hypertensive animals and the spontaneously-hy...

journal_title：Life sciences

authors： Trachtman H,del Pizzo R,Sturman J

更新日期：1990-01-01 00:00:00

abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...

journal_title：Life sciences

authors： Benschop RJ,Jabaaij L,Oostveen FG,Vingerhoets AJ,Kirschbaum C,Duivenvoorden HJ,Ballieux RE

更新日期：1993-01-01 00:00:00

abstract：:PD 128907 [4a R, 10 b R-(+)-trans-3, 4, 4a, 10 b - tetrahydro - 4- n -propyl2 H,5H-[1]benzop-yrano[4,3-b]1,4-oxazin-9-ol.], a selective dopamine (DA) D3 receptor agonist ligand exhibits about a 1000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a 10000-fold selectivity ...

journal_title：Life sciences

authors： Akunne HC,Towers P,Ellis GJ,Dijkstra D,Wikström H,Heffner TG,Wise LD,Pugsley TA

更新日期：1995-01-01 00:00:00

abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...

journal_title：Life sciences

authors： Guimarães AG,Scotti L,Scotti MT,Mendonça Júnior FJ,Melo NS,Alves RS,De Lucca Júnior W,Bezerra DP,Gelain DP,Quintans Júnior LJ

更新日期：2014-10-22 00:00:00

abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...

journal_title：Life sciences

authors： Ali S,Al-Sukhun S,El-Rayes BF,Sarkar FH,Heilbrun LK,Philip PA

更新日期：2009-05-22 00:00:00

abstract：:Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase incr...

journal_title：Life sciences

authors： José HJ,Berenice SG,Cecilia VR

更新日期：1997-01-01 00:00:00

abstract：:The important immunological activities of Thymosin alpha 1 (T alpha 1), a peptide derived from the thymus, led to its use in combination therapies in cancer patients. Prothymosin alpha (ProT alpha) is a highly acidic polypeptide, first isolated as the putative precursor of T alpha 1. However ProT alpha is now known to...

journal_title：Life sciences

authors： Cordero OJ,Sarandeses CS,Nogueira M

更新日期：1996-01-01 00:00:00

abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...

journal_title：Life sciences

authors： Yanagida M,Gohda E,Yamamoto I

更新日期：1996-01-01 00:00:00

abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...

journal_title：Life sciences

authors： Furfine ES,Carbine K,Bunker S,Tanoury G,Harmon M,Laubach V,Sherman P

更新日期：1997-01-01 00:00:00