Abstract:
:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephrine-induced renin secretion is initiated by a change in blood composition, independent of the passage of the blood through any organ. Accordingly, the left kidneys of anesthetized dogs were perfused with femoral arterial blood via an extracorporeal circuit. The circuit consisted of large-bore Tygon tubing (157 ml volume) with an infusion port and a mixing chamber near the femoral arterial origin, and a blood sampling and pressure-monitoring site near the renal artery. A roller pump was used to maintain renal perfusion pressure approximately equal to femoral arterial pressure, and renal blood flow was measured with an electromagnetic flowmeter. Transit time (of a dye) in the extracorporeal circuit was approximately 40 seconds. Intravenous infusion of epinephrine at 25 ng X kg-1 X min-1 increased renin secretion significantly. However, infusion of epinephrine into the extracorporeal circuit at a rate of 5 ng X kg-1 X min-1 did not alter renin secretion, even though epinephrine concentration in the renal perfusate was higher than during intravenous infusion. The data do not support the hypothesis that epinephrine-induced renin secretion is initiated by a direct effect of epinephrine on blood composition, independent of the passage of blood through any organ.
journal_name
Life Scijournal_title
Life sciencesauthors
Johnson MDdoi
10.1016/0024-3205(87)90747-8subject
Has Abstractpub_date
1987-10-19 00:00:00pages
1945-51issue
16eissn
0024-3205issn
1879-0631pii
0024-3205(87)90747-8journal_volume
41pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117778
更新日期:2020-08-01 00:00:00
abstract::This review aims to systematically review and synthesize scientific evidence for the influence of air pollution exposure and outdoor exercise on health. We conducted a literature search in the PubMed, Cochrane, EMBASE, and Web of Science for articles that evaluated the combination effect of air pollution exposure and ...
journal_title:Life sciences
pub_type: 杂志文章,meta分析
doi:10.1016/j.lfs.2018.12.036
更新日期:2019-02-01 00:00:00
abstract::Nephrotoxicity is a limiting factor in the use of ifosfamide in children. Despite the co-administration of uroprotective agents such as sodium 2-mercaptoethanesulfonate (mesna), ifosfamide chemotherapy is associated with nephropathy characterized by glomerular toxicity and Fanconi syndrome in many children treated wit...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00915-2
更新日期:2000-11-24 00:00:00
abstract::Plasma levels of prolactin, growth hormone, glucagon insulin and glucose were measured in non-treated control rats, bromocriptine-treated control rats and GH3-cell-tumor-bearing rats with and without bromocriptine treatment. Bromocriptine treatment increased plasma levels of glucagon, insulin and glucose in control ra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90042-1
更新日期:1986-08-18 00:00:00
abstract::The neurological mutant whirler mouse, one of several strains of waltzing mice, may be suitable as an animal model for testing studies relative to hyperkinesis. As in hyperkinetic children, behaviorally the mice are extremely restless, nervous, excitable, irritable and aggressive but also show symptoms of rotation beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90404-7
更新日期:1985-08-05 00:00:00
abstract::The effects of unilateral intracarotid administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in sheep were studied with the goal of producing a non-primate, large animal model of Parkinson's Disease. Adult female sheep were given an acute (over 30 min) or chronic (over 1 week) injection of MPTP (0.4-5....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00406-4
更新日期:1994-01-01 00:00:00
abstract::The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90060-8
更新日期:1985-01-21 00:00:00
abstract:AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.064
更新日期:2016-04-15 00:00:00
abstract::Heterotrimeric G-protein signalling systems are primarily activated via cell surface receptors possessing the seven membrane span motif. Several observations suggest the existence of other modes of input to such signalling systems either downstream of effectors or at the level of G-proteins themselves. Using a functio...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(01)01019-0
更新日期:2001-04-06 00:00:00
abstract::Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.117734
更新日期:2020-08-01 00:00:00
abstract::CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.06.026
更新日期:2008-08-29 00:00:00
abstract::The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00981-4
更新日期:2001-01-05 00:00:00
abstract::The platelet activating factor (PAF) receptor of the guinea pig peritoneal eosinophil was characterized by radioligand ([3H]WEB 2086) binding and measurement of PAF-stimulated membrane GTPase activity. Specific binding of [3H]WEB 2086 was rapid, reversible and saturable, with an equilibrium KD of 20.4 nM at 0 degrees ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90045-5
更新日期:1993-01-01 00:00:00
abstract::The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.01.018
更新日期:2008-04-09 00:00:00
abstract::Recent studies on the control of adrenal zona glomerulosa function and aldosterone secretion have focussed attention on the role of MSH-like peptides. In particular, at low concentrations, alpha-MSH has a specific stimulatory effect on rat adrenal glomerulosa cells. The synthesis of alpha-MSH analogues which have pote...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90255-8
更新日期:1984-08-06 00:00:00
abstract::The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.02.025
更新日期:2006-07-04 00:00:00
abstract::We describe here a nonpeptide neuropeptide Y Y1 receptor antagonist, 2,4-dioxo-1,5-bis(2-oxo-2-orthotolyl-ethyl)-3-[3-[3-([3-[3-(3-p iperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propyl]-car bamoyloxymethyl)-phenyl]-ureido]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diaz epine (Compound 1), which was previously synthesized as...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00357-9
更新日期:1998-01-01 00:00:00
abstract::Aspartate (ASP), glutamate (GLU), noradrenaline (NA), dopamine (DA) and its acidic metabolites DOPAC and HVA, serotonin (5-HT) and its metabolite 5-HIAA were simultaneously investigated in post-mortem tissue samples from right parahippocampal gyrus (temporal cortex) and frontal cortical pole (frontal cortex) of adults...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00067-2
更新日期:1997-01-01 00:00:00
abstract::An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90175-0
更新日期:1988-01-01 00:00:00
abstract::Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02106-9
更新日期:2002-10-18 00:00:00
abstract:AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.03.011
更新日期:2017-05-01 00:00:00
abstract::Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01843-x
更新日期:2002-08-09 00:00:00
abstract::The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.06.013
更新日期:2008-08-15 00:00:00
abstract::Systemic administration of the selective D1 antagonist, SCH 23390, caused significant motor changes in healthy African green monkeys. The effects included the parkinsonian signs of motor freezing, incoordination, bradykinesia, poverty of movement, tremor and depressed blink rate. SCH 23390 administered to MPTP-treated...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90299-q
更新日期:1991-01-01 00:00:00
abstract::In this study we analyzed the N-formyl-Met-Leu-Phe (fMLP)-induced calcium signal in alveolar macrophages (AM) isolated from ovalbumin-sensitized (OA-sensitized AM) and naive (naive AM) guinea-pigs. Guinea-pigs were sensitized by subcutaneous injection of OA and AM were isolated by bronchoalveolar lavage 6 weeks therea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01239-5
更新日期:2001-08-24 00:00:00
abstract::This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90277-a
更新日期:1993-01-01 00:00:00
abstract:AIMS:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly through binding to angiotensin converting enzyme 2 (ACE2) via its S-protein. Genetic analysis of (ACE2) gene revealed several variants that have been suggested t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118219
更新日期:2020-10-15 00:00:00
abstract::In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00181-2
更新日期:1999-01-01 00:00:00
abstract::The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days. The doses of 0.025, 0.05, 0.25, 0.5 and 1.0 mg/kg were administered immediately before Metrazol (100 mg/kg in all but 18-day-old animals where 90 mg/kg were ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90421-k
更新日期:1992-01-01 00:00:00
abstract::The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.04.012
更新日期:2004-08-27 00:00:00