Abstract：
:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 months. Blood was collected and plasma aldosterone (PA) was estimated with radioimmunoassay (RIA). Ex vivo heart perfusion was performed, the ex vivo cardiac aldosterone (EXCA) was assessed by RIA after high-performance liquid chromatography separation. PA and EXCA were significantly decreased after one month but increased after 4 months in valsartan administration group. The combined valsartan and spironolactone therapy normalized cardiac aldosterone levels. This study provides the first evidence that the long-term treatment with Angiotensin II type 1 receptor antagonist (AT1A) induces local aldosterone escape in cardiovascular tissue, whereas the combined AT1A and spironolactone therapy inhibits the escape in hypertensive rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CXdoi
10.1016/j.lfs.2004.04.012subject
Has Abstractpub_date
2004-08-27 00:00:00pages
1871-8issue
15eissn
0024-3205issn
1879-0631pii
S0024320504004825journal_volume
75pub_type
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