Abstract：
:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylactic experiment, bicyclol (100 and 200mg.kg(-1)) was administered by gavage in association with DMN injection. For the therapeutic experiment, mice were firstly injected with DMN for 5 weeks as in the prophylactic experiment, and then the mice in drug groups were orally administered bicyclol (100 and 200mg.kg(-1)) once daily for 5 weeks. As a result, the levels of alanine aminotransferase (ALT), total bilirubin, hydroxyproline (Hyp), prolidase, tumor necrosis factor-alpha (TNFalpha), transforming growth factor beta-1 (TGFbeta(1)), type I collagen in serum and the score of liver fibrosis all significantly increased in the hepatic fibrosis model group in comparison with those in control group. The treatment with bicyclol markedly reduced all the above criteria. Bicyclol also attenuated the decrease of body weight of mice, serum total protein and albumin. In addition, bicyclol treatment inhibited liver TGFbeta(1) and tissue inhibitor of metalloproteinase 1 (TIMP-1) mRNA expression in the prophylactic experiment. Similarly, bicyclol reduced TIMP-1 levels in liver and serum and increased collagenase activity in the liver in the therapeutic experiment. The result suggest that bicyclol attenuates DMN-induced hepatic fibrosis in mice. Its mechanisms of action may be related to the hepatoprotective and anti-inflammation properties, the down-regulation of liver TGFbeta(1) and TIMP-1 expression and the increase of net collagenase activity in liver.
journal_name
Life Scijournal_title
Life sciencesauthors
Hu QW,Liu GTdoi
10.1016/j.lfs.2006.02.025subject
Has Abstractpub_date
2006-07-04 00:00:00pages
606-12issue
6eissn
0024-3205issn
1879-0631pii
S0024-3205(06)00178-0journal_volume
79pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The opiate antagonist naloxone was found to block nitrous oxide analgesia in a stereospecific fashion. Using a modified hotplate test in mice, the (-)-enantiomer of naloxone (which has a KD of approximately 1 nM for opiate receptors) antagonized the analgesic actions of nitrous oxide in a dose-dependent (2.5-20 mg/kg)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90381-0
更新日期：1989-01-01 00:00:00
abstract：AIMS:Studies using transgenic mouse strains that incorporate Alzheimer's disease (AD) mutations are valuable for the identification of signaling pathways, potential drug targets, and possible mechanisms of disease that will aid in our understanding of AD. However, reports on the effects of specific AD mutations (Swedis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.04.014
更新日期：2010-06-19 00:00:00
abstract：:Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.04.004
更新日期：2008-06-20 00:00:00
abstract：:The acute dose-dependent effects of epinephrine and cocaine on heart rate and coronary flow rate (CFR) were examined in isolated, perfused (Langendorff) rat hearts from animals: i) pretreated with daily cocaine injections (20 mg/kg/day) for 8 weeks; ii) after 2-day withdrawal from 8-week cocaine pretreatment; iii) veh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90390-d
更新日期：1990-01-01 00:00:00
abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90055-v
更新日期：1990-01-01 00:00:00
abstract：:Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.07.027
更新日期：2005-02-11 00:00:00
abstract：:The present experiment was designed to determine whether scavenging capacity of serum, in addition to glucose level, influences hemoglobin and serum protein glycosylation in non-insulin dependent diabetic patients. For this purpose forty-seven patients homogeneous for age, disease duration, therapy and glyco-metabolic...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00256-1
更新日期：1996-01-01 00:00:00
abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90598-8
更新日期：1984-01-16 00:00:00
abstract：:The novel guanidines N-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine (ME 10092) and N-(3,4-dimethoxy-2-chlorobenzylideneamino)-N1-hydroxyguanidine (PR5) were recently reported to exhibit promising cardioprotective activities in myocardial ischaemia and reperfusion in rats. The current study investigated for the f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.03.030
更新日期：2004-09-10 00:00:00
abstract：:Certain pharmacological properties of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, have been investigated in chicks. Although beta-CCM has been established previously as an "inverse agonist" of benzodiazepine receptors in rodents, having effects opposite to those of benzodiazepines...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90201-8
更新日期：1986-09-22 00:00:00
abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90105-4
更新日期：1983-05-02 00:00:00
abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00025-2
更新日期：1995-01-01 00:00:00
abstract：:Quetiapine, a new atypical antipsychotic drug, has beneficial effects on cognitive impairment and neuropathological changes in treating chronic neurodegenerative diseases. Our previous studies have demonstrated that quetiapine may have neuroprotective properties. In the present study, we investigated the effects of a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.05.020
更新日期：2007-07-12 00:00:00
abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00512-3
更新日期：1999-10-29 00:00:00
abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.02.011
更新日期：2012-10-15 00:00:00
abstract：:Pharmacokinetic and pharmacodynamic interactions between simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and diltiazem, a calcium antagonist, were investigated in 7 male and 4 female patients with hypercholesterolemia and hypertension. The patients were given, for one in a three con...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/j.lfs.2004.06.022
更新日期：2004-12-03 00:00:00
abstract：:Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01510-2
更新日期：2002-04-19 00:00:00
abstract：:When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.06.032
更新日期：2003-11-21 00:00:00
abstract：:5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with alpha-methyl 5-HT or prostaglandin F2 alpha. Relaxation was not blocked by propranolol (1 micron), atropine (1 micron), indomethacin (3 microns), mepyramine (1 micron), cimetidine (1 micron), o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90240-6
更新日期：1984-07-30 00:00:00
abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90638-7
更新日期：1986-06-23 00:00:00
abstract：:The effect of maternal glucocorticoid depletion upon the fetal development of the organ of Zuckerkandl (OZ) in rats was determined. Maternal hypophysectomy at 13d8h gestation resulted in a fifty percent decrease in plasma corticosterone levels at 18d8h when compared to both sham operated and unoperated controls. No di...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90609-6
更新日期：1987-09-14 00:00:00
abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01710-1
更新日期：2002-06-21 00:00:00
abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.036
更新日期：2016-01-15 00:00:00
abstract：:Ischemic preconditioning (IP) may protect the lung from ischemia-reperfusion (I/R) injury following cardiopulmonary by-pass and lung or heart transplantation. The present study was undertaken to investigate the role of ATP-dependent potassium channels (K(ATP)) in IP in the isolated buffer-perfused rat lung (IBPR) unde...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.011
更新日期：2006-11-02 00:00:00
abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.12.002
更新日期：2017-02-01 00:00:00
abstract：:Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90072-5
更新日期：1987-06-29 00:00:00
abstract：:The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90532-t
更新日期：1992-01-01 00:00:00
abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(93)90295-e
更新日期：1993-01-01 00:00:00
abstract：AIMS:Proton Nuclear Magnetic Resonance (NMR) based metabolomics analysis is extensively used to explore the metabolic profiling of biofluids. This approach was used for the analysis of metabolites in serum of patients with major types of muscular dystrophy in early phase of the disease. MATERIAL AND METHODS:Proton NMR...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.01.032
更新日期：2016-04-15 00:00:00
abstract：:The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic etha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00396-8
更新日期：1998-01-01 00:00:00
