Abstract：
:The opiate antagonist naloxone was found to block nitrous oxide analgesia in a stereospecific fashion. Using a modified hotplate test in mice, the (-)-enantiomer of naloxone (which has a KD of approximately 1 nM for opiate receptors) antagonized the analgesic actions of nitrous oxide in a dose-dependent (2.5-20 mg/kg) fashion. In contrast, the (+)-enantiomer (KD approximately 10,000 nM) had no effect on nitrous oxide analgesia at the highest dose tested (40 mg/kg). These data strongly suggest that nitrous oxide analgesia is mediated via opiate receptors and is consistent with the hypotheses that this effect occurs either through the release of endogenous opioids or by physical perturbation of the opiate receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
Moody EJ,Mattson M,Newman AH,Rice KC,Skolnick Pdoi
10.1016/0024-3205(89)90381-0subject
Has Abstractpub_date
1989-01-01 00:00:00pages
703-9issue
11eissn
0024-3205issn
1879-0631pii
0024-3205(89)90381-0journal_volume
44pub_type
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