Abstract:
:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different age groups at various times after EEDQ injection. These results suggest that loss of striatal dopamine receptors during aging may be due to a decreased biosynthetic rate.
journal_name
Life Scijournal_title
Life sciencesauthors
Henry JM,Roth GSdoi
10.1016/0024-3205(84)90416-8subject
Has Abstractpub_date
1984-08-20 00:00:00pages
899-904issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(84)90416-8journal_volume
35pub_type
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