Chagasic IgG modifies the activity of sarcolemmal ATPases through a beta adrenergic mechanism.

abstract：:The effect of endothelin (END) on the release of atrial natriuretic peptides (ANP) was studied in isolated rat atria and in conscious rats. END stimulates the ANP release in vitro in a dose-dependent manner. An increase in ANP plasma levels and cyclic GMP plasma levels was also observed in conscious rats after injecti...

journal_title：Life sciences

authors： Stasch JP,Hirth-Dietrich C,Kazda S,Neuser D

更新日期：1989-01-01 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：:Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicit...

journal_title：Life sciences

authors： Beach JE,Smallridge RC,Kinzer CA,Bernton EW,Holaday JW,Fein HG

更新日期：1989-01-01 00:00:00

abstract：:Dopamine receptors in human parathyroid were studied in vitro using ligand binding techniques. With 3H-piflutixol as ligand, binding characteristic of the dopamine D1 receptor was observed. Administration of apomorphine, flupenthixol or metoclopramide to normal controls or acute schizophrenic patients at doses produci...

journal_title：Life sciences

authors： Cross AJ,Ferrier IN,Bloxham CA

更新日期：1983-08-22 00:00:00

abstract：:Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...

journal_title：Life sciences

authors： Chauhan A,Chauhan VP,Brockerhoff H,Wisniewski HM

更新日期：1991-01-01 00:00:00

abstract：:Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...

journal_title：Life sciences

authors： Yun J,Lee CK,Chang IM,Takatsu K,Hirano T,Min KR,Lee MK,Kim Y

更新日期：2000-10-27 00:00:00

abstract：AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...

journal_title：Life sciences

authors： Zhou MW,Jiang RH,Kim KD,Lee JH,Kim CD,Yin WT,Lee JH

更新日期：2016-06-15 00:00:00

abstract：AIM:We previously reported the possible involvement of mucosal nitric oxide (NO)-triggered 5-HT release in luminal glutamate sensing by the gastric vagus nerve, and we proposed that the stomach, like the duodenum, could "taste" luminal nutrients. Nitric oxide synthase (NOS) is widely distributed in the gastric mucosa, ...

journal_title：Life sciences

authors： Uneyama H,Niijima A,Kitamura A,Torii K

更新日期：2009-12-16 00:00:00

abstract：:Physiological, pharmacological and toxicological responses to two regimens of cocaine administration were compared between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. An initial experiment examined renal excretory and hemodynamic function in response to an acute volume load in anesthetized SHR and WK...

journal_title：Life sciences

authors： Ishizuka Y,Rockhold RW,Kirchner K,Hoskins B,Ho IK

更新日期：1989-01-01 00:00:00

abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

journal_title：Life sciences

authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

更新日期：1987-05-25 00:00:00

abstract：:The potency of six antimuscarinic oxotremorine analogs at sympathetic ganglionic M1 and brainstem M2 muscarinic receptors was compared in the rat. Inhibition of the pressor effects of McNA343 or physostigmine was used as functional indicators of M1 and M2 blockade, respectively. 50% inhibitory doses (ID50) were calcul...

journal_title：Life sciences

authors： Vargas HM,Ringdahl B

更新日期：1990-01-01 00:00:00

abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...

journal_title：Life sciences

authors： Sheppard MN,Marangos PJ,Bloom SR,Polak JM

更新日期：1984-01-16 00:00:00

abstract：:Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...

journal_title：Life sciences

authors： Holsapple MP,Munson AE,Freeman AS,Martin BR

更新日期：1982-08-23 00:00:00

abstract：:Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report,...

journal_title：Life sciences

authors： Chen GG,Lee JF,Wang SH,Chan UP,Ip PC,Lau WY

更新日期：2002-04-19 00:00:00

abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

journal_title：Life sciences

authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

更新日期：2004-03-26 00:00:00

abstract：:Polyinosinic polycytidylic acid (poly I:C) is an analog of double stranded RNA, which is a common replication intermediate for many viruses. It acts through a toll-like receptor (TLR3) to induce a group of cytokines that can mediate host resistance to viruses and some cancers. The effect of ethanol (EtOH) on induction...

journal_title：Life sciences

authors： Pruett SB,Fan R,Zheng Q

更新日期：2003-03-07 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to examine whether the adhesion of polymorphonuclear leukocytes (PMNs) to endothelial cells and/or reactive oxygen species (ROS) released from PMNs are responsible for inducing angiogenesis. Angiogenesis was assessed by tube formation using endothelial cells obtained from bovine thoracic ...

journal_title：Life sciences

authors： Yasuda M,Shimizu S,Tokuyama S,Watanabe T,Kiuchi Y,Yamamoto T

更新日期：2000-04-14 00:00:00

abstract：:The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices. Field potentials were evoked by stimulation of Schaffer collaterals, and recorded from the CA1 region of the hippocampus after infusion of 4-AP in the absence an...

journal_title：Life sciences

authors： Camacho-Ochoa M,VonVoigtlander PF,Hoffmann WE,Piercey MP

更新日期：1992-01-01 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...

journal_title：Life sciences

authors： Chang YC,Lin CW,Chang YS,Chen PH,Li CY,Wu WC,Kao YH

更新日期：2020-10-15 00:00:00

abstract：:Nitric oxide (NO) plays a critical role in the pathogenesis of endotoxin-induced uveitis (EIU). Since NO is a labile free radical, it is difficult to examine the dynamics of NO directly in vivo. In this study, we established a system for direct monitoring of the dynamics of NO and partial pressure of oxygen (pO(2)) in...

journal_title：Life sciences

authors： Yomura Y,Shoji Y,Asai D,Murakami E,Ueno S,Nakashima H

更新日期：2007-03-27 00:00:00

abstract：:In an effort to obtain highly potent glucagon antagonists, we have investigated glucagon (1) structure-function relationships utilizing the following design principles: (1) structural changes known to lead to partial agonist activities; (2) conformational restrictions; (3) changes in the conformational probabilities o...

journal_title：Life sciences

authors： Hruby VJ,Gysin B,Trivedi D,Johnson DG

更新日期：1993-01-01 00:00:00

abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

journal_title：Life sciences

authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

更新日期：2005-02-25 00:00:00

abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...

journal_title：Life sciences

authors： Wei Z,Hao Y,Yu H,Shi L,Jing X,Zhang X,Liu N,Li T,Zhang X,Yuan F

更新日期：2020-09-15 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...

journal_title：Life sciences

authors： Kasckow JW,Regmi A,Sheriff S,Mulchahey J,Geracioti TD Jr

更新日期：1999-01-01 00:00:00