Abstract：
:Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report, we show that the expression of PPARgamma was significantly increased in tumor tissues from human colon cancer compared with non-tumor tissues and that PPARgamma ligands, 15-Deoxy-delta(12,14)prostaglandin J2 or ciglitizone, induced apoptosis in HT-29 cells, a human colon cancer cell line. The occurrence of apoptosis induced by PPARgamma ligands was sequentially accompanied by reduced levels of NF-kappaB and Bcl-2. Over-expression of Bcl-2 significantly protected the cells from apoptosis. This study suggested that a PPARgamma-Bcl-2 feedback loop may function to control the life-death continuum in colonic cells and that a deficiency in generation of PPARgamma ligands may precede the development of human colon cancer.
journal_name
Life Scijournal_title
Life sciencesauthors
Chen GG,Lee JF,Wang SH,Chan UP,Ip PC,Lau WYdoi
10.1016/s0024-3205(02)01510-2subject
Has Abstractpub_date
2002-04-19 00:00:00pages
2631-46issue
22eissn
0024-3205issn
1879-0631pii
S0024-3205(02)01510-2journal_volume
70pub_type
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