Abstract：
:Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms of rectal temperatures and rotorod activity both 20 and 60 min after drug administration. Verapamil alone did not affect body temperature, but it potentiated ethanol-induced hypothermia at both post-administration test times. Both verapamil and ethanol impaired muscular coordination and these effects were additive at the two observation periods. Verapamil did not affect ethanol blood levels from 10 to 80 min after administration of the drugs. Since motor impairment was observed when verapamil was administered with only its ethanol vehicle, this suggests a powerful interactive effect between the two drugs.
journal_name
Life Scijournal_title
Life sciencesauthors
Johnston JE,Draski LJ,Molina JC,Burright RG,Reynoso G,Calendrillo BA,Isaacson RLdoi
10.1016/0024-3205(86)90357-7subject
Has Abstractpub_date
1986-12-01 00:00:00pages
2067-72issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(86)90357-7journal_volume
39pub_type
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