Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937).

abstract：AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...

journal_title：Life sciences

authors： Lobato NS,Filgueira FP,Hagihara GN,Akamine EH,Pariz JR,Tostes RC,Carvalho MH,Fortes ZB

更新日期：2012-01-30 00:00:00

abstract：:The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...

journal_title：Life sciences

authors： Ogura J,Kobayashi M,Itagaki S,Hirano T,Iseki K

更新日期：2008-06-20 00:00:00

abstract：:Aging exerts profound influences on the function of the hypothalamic-pituitary-testicular-axis. This work has been performed in order to verify whether, in male rats, the decreased secretion of LH and testosterone (T) occurring in old animals is reflected by modifications of luteinizing hormone-releasing hormone (LHRH...

journal_title：Life sciences

authors： Limonta P,Dondi D,Maggi R,Martini L,Piva F

更新日期：1988-01-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：:The association between various parameters of acute and chronic smoking status and plasma levels of three proteins, C9, C1-inhibitor (C1-INH) and alpha 1-protease inhibitor (alpha 1-PI) were determined for 49 male cigarette smokers and 49 age-matched nonsmokers (mean age = 32.2 years). The mean number of cigarettes sm...

journal_title：Life sciences

authors： Bridges RB,Rehm SR,Wyatt RJ

更新日期：1985-03-11 00:00:00

abstract：:We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...

journal_title：Life sciences

authors： McMillen IC,Jenkin G,Haji-Baba AS,Browne CA,Thorburn GD

更新日期：1989-01-01 00:00:00

abstract：:Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...

journal_title：Life sciences

authors： Yu WH,Riedel M,Yamashiro D,Ramasharma K,McCann SM

更新日期：1994-01-01 00:00:00

abstract：:SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...

journal_title：Life sciences

authors： Arce A,Aicher L,Wahl D,Anderson NL,Meheus L,Raymackers J,Cordier A,Steiner S

更新日期：1998-01-01 00:00:00

abstract：:The parasympathetic nervous system is a key regulator of the human organism involved in the pathophysiology of various disorders through cholinergic mechanisms. In the lungs, acetylcholine (ACh) released by vagal nerve endings stimulates muscarinic receptors thereby increasing airway smooth muscle tone. Contraction of...

journal_title：Life sciences

authors： Pieper MP

更新日期：2012-11-27 00:00:00

abstract：:In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

journal_title：Life sciences

authors： Li Y,Lafuente A,Trush MA

更新日期：1994-01-01 00:00:00

abstract：:Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...

journal_title：Life sciences

authors： Ramaswamy S,Pillai NP,Gopalakrishnan V,Ghosh MN

更新日期：1983-09-19 00:00:00

abstract：AIMS:High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high f...

journal_title：Life sciences

authors： Losacco MC,de Almeida CFT,Hijo AHT,Bargi-Souza P,Gama P,Nunes MT,Goulart-Silva F

更新日期：2018-06-01 00:00:00

abstract：AIMS:Two natural alkaloids, methyl (M) and isopropyl (I) N-methylanthranilates, with recently demonstrated significant pharmacological activities, were assayed for their possible overall effect on intact gastric mucosa and their protective properties towards the onset of gastric lesions induced by diclofenac (a non-ste...

journal_title：Life sciences

authors： Radulović NS,Jovanović I,Ilić IR,Randjelović PJ,Stojanović NM,Miltojević AB

更新日期：2013-11-19 00:00:00

abstract：:The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties controlling the bidirectional exchange of molecules between the general circulation and the central nervous system. As lipophilic molecules are able to easily penetrate the membrane of brain microvessels endothelial cells, an...

journal_title：Life sciences

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1988-01-01 00:00:00

abstract：:A simple, selective reverse-phase HPLC-fluorometric method is described for the determination of serotonin (5HT) in cisternal CSF of the rat. The mean (+/- SE) value of CSF 5HT observed in control adult rats was 457 +/- 83 pg/ml (N = 16). In an attempt to validate the measure as an index of extracellular, or functiona...

journal_title：Life sciences

authors： Anderson GM,Teff KL,Young SN

更新日期：1987-06-08 00:00:00

abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

journal_title：Life sciences

authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

更新日期：2018-12-01 00:00:00

abstract：AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incub...

journal_title：Life sciences

authors： Lv J,Chen FK,Liu C,Liu PJ,Feng ZP,Jia L,Yang ZX,Hou F,Deng ZY

更新日期：2020-09-01 00:00:00

abstract：AIMS:Systemic administration of opiate analgesics such as morphine remains the most effective treatment for alleviating severe pain across a range of conditions including acute pain. However, chronic or repeated administration of opiate analgesics results in the development of analgesic tolerance. Glial cells such as m...

journal_title：Life sciences

authors： Harada S,Nakamoto K,Tokuyama S

更新日期：2013-10-11 00:00:00

abstract：:Decreased sweat secretion is a primary side effect of topiramate in pediatric patients, but the mechanism underlying this effect remains unclear. This study aimed to better understand how topiramate decreases sweat secretion by examining its effect on the expression of carbonic anhydrase (CA) II and aquaporin-5 (AQP5)...

journal_title：Life sciences

authors： Ma L,Huang YG,Deng YC,Tian JY,Rao ZR,Che HL,Zhang HF,Zhao G

更新日期：2007-06-06 00:00:00

abstract：:The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...

journal_title：Life sciences

authors： Raj P,Louis XL,Thandapilly SJ,Movahed A,Zieroth S,Netticadan T

更新日期：2014-01-30 00:00:00

abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...

journal_title：Life sciences

authors： Cho DI,Koo NY,Chung WJ,Kim TS,Ryu SY,Im SY,Kim KM

更新日期：2002-09-13 00:00:00

abstract：:Swim therapy in the form of moderate physical activity has general health benefits. Regular exercise prevents the progression of chronic diseases affecting the different bodily systems. The metabolic alterations associated with following such lifestyle remain not fully understood. The aim of the present study was to e...

journal_title：Life sciences

authors： Moustafa A,Arisha AH

更新日期：2020-12-01 00:00:00

abstract：:In the present study, we elucidated the possible role of hemodynamic parameters and chemical factors in the development of ventricular hypertrophy (VH) following chronic nitric oxide (NO) deprivation with Nomega-nitro-L-arginine methyl ester (L-NAME). Impedance spectral analysis was used to obtain the arterial hemodyn...

journal_title：Life sciences

authors： Hu CT,Chang HR,Hsu YH,Liu CJ,Chen HI

更新日期：2005-11-26 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (app) and V were alt...

journal_title：Life sciences

authors： Catalán RE,Martínez AM,Aragonés MD,Miguel BG,Hernández F,Cruz E

更新日期：1993-01-01 00:00:00

abstract：:Hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix, has regulatory influences on cells and cellular activities. To explore the effects of a high concentration (1 mg/mL) of high molecular weight HA (500-730 kD) on U937 macrophage growth dynamics, three factors that influence overall c...

journal_title：Life sciences

authors： Sheehan KM,DeLott LB,West RA,Bonnema JD,DeHeer DH

更新日期：2004-11-12 00:00:00

abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

journal_title：Life sciences

authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

更新日期：2000-10-06 00:00:00

abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

journal_title：Life sciences

authors： Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

更新日期：1986-03-17 00:00:00

abstract：:The effects of delta 9-THC and other cannabinoids on cAMP levels in synaptosomes from mouse brains were investigated in order to determine whether cannabinoids produced their behavioral effects through alterations in adenylate cyclase. delta 9-THC (0.01-10 microM) did not significantly alter basal cAMP levels, whereas...

journal_title：Life sciences

authors： Little PJ,Martin BR

更新日期：1991-01-01 00:00:00

abstract：:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a cri...

journal_title：Life sciences

authors： Yang DF,Shen YL,Wu C,Huang YS,Lee PY,Er NX,Huang WC,Tung YT

更新日期：2019-10-15 00:00:00