Differential inhibitory effects of sophoricoside analogs on bioactivity of several cytokines.

abstract：:Human milk was tested in the Ames plate incorporation test using strain TA98. Pools from smokers and non-smokers respectively, as well as individual samples from 14 smokers and 15 controls were tested. No difference was found between milk from smokers and non-smokers in the concentrations and volumes used. Preliminary...

journal_title：Life sciences

authors： Rivrud GN,Hagen I,Børresen AL

更新日期：1987-11-23 00:00:00

abstract：:In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, d...

journal_title：Life sciences

authors： Johnson DC

更新日期：1996-01-01 00:00:00

abstract：:Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction. Moreover, excess nu...

journal_title：Life sciences

authors： de Mello AH,Costa AB,Engel JDG,Rezin GT

更新日期：2018-01-01 00:00:00

abstract：:Opiate addiction could involve a change in the binding of endogenous antiopiates. A candidate for such a role is Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a brain peptide that can antagonize exogenous and endogenous opiates and bind to opiate receptors. Its primary action, however, may be through its own binding site in brain,...

journal_title：Life sciences

authors： Zadina JE,Kastin AJ,Ge LJ,Gulden H,Bungart KJ

更新日期：1989-01-01 00:00:00

abstract：:Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase incr...

journal_title：Life sciences

authors： José HJ,Berenice SG,Cecilia VR

更新日期：1997-01-01 00:00:00

abstract：:Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...

journal_title：Life sciences

authors： Mennini T,Gobbi M

更新日期：2004-07-16 00:00:00

abstract：:Skeletal muscle viability is crucially dependent on the tissue levels of its high energy phosphates. In this study we investigated the effect of the preservation medium Perfadex and illumination with Singlet Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by energy transfer from an excited photosen...

journal_title：Life sciences

authors： Lindgård A,Lundberg J,Rakotonirainy O,Elander A,Soussi B

更新日期：2003-04-25 00:00:00

abstract：:A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect ...

journal_title：Life sciences

authors： Wong JY,Lee EJ,Moochhala SM

更新日期：1993-01-01 00:00:00

abstract：:Prolonged use of glucocorticoids is associated with decreased bone formation, increased resorption and osteonecrosis, through direct and indirect effects on the activity and viability of bone effector cells, osteoblasts and osteoclasts, and osteocytes. This study has investigated molecular pathways implicated in Dexam...

journal_title：Life sciences

authors： Kogianni G,Mann V,Ebetino F,Nuttall M,Nijweide P,Simpson H,Noble B

更新日期：2004-10-29 00:00:00

abstract：:The effects of social crowding in rats on nociception and analgesic actions of mu- and kappa-opioid agonists agonist qualitatively different stimuli were examined. Crowding produced higher control thresholds for electroshock and paw pinch pressure but not for noxious heat. Naloxone did not effect shock thresholds in c...

journal_title：Life sciences

authors： Pilcher CW,Browne J

更新日期：1982-09-20 00:00:00

abstract：AIMS:With the improvement of the survival rates in children acute lymphoblastic leukemia (ALL), some children ALL survivors show impaired cognitive function. Methotrexate (MTX), an essential component in ALL treatment, has been reported to be related to neurologic sequelae and to increased oxidative stress through its ...

journal_title：Life sciences

authors： Chen YC,Sheen JM,Hsu MH,Hsiao CC,Wang SC,Huang LT

更新日期：2020-02-01 00:00:00

abstract：:To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previously. Plasma ghrelin levels were measured by both N-RIA recognizing th...

journal_title：Life sciences

authors： Okimura Y,Ukai K,Hosoda H,Murata M,Iguchi G,Iida K,Kaji H,Kojima M,Kangawa K,Chihara K

更新日期：2003-04-18 00:00:00

abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

journal_title：Life sciences

authors： Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

更新日期：2013-03-28 00:00:00

abstract：:Restraint stress is known to induce gastric ulcers in rats. Peripheral sympathetic activity and catecholamines are involved in the pathogenesis of these gastric ulcers. The aim of the present study was to evaluate the effects of restraint on mucosal and muscle catecholamine concentrations in the glandular stomach of r...

journal_title：Life sciences

authors： Gaudin C,Safar M,Cuche JL

更新日期：1990-01-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of the neurohypophyseal neuropeptide arginine8-vasopressin (AVP) results in a dose-dependent attenuation of endotoxin-induced fever (EIF) in rats. Specific antagonists of the neuropeptided(CH2)5[Tyr(Me)2]AVP for V1 receptors, d(CH2)5[dlle2lle4]AVP for the V2 receptors an...

journal_title：Life sciences

authors： Kovacs GL,Baars AM,De Wied D

更新日期：1992-01-01 00:00:00

abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

journal_title：Life sciences

authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

更新日期：2016-01-01 00:00:00

abstract：:Morphine and the enkephalin-like peptide FK 33-824 given i.p. to rats potently inhibit gastrointestinal transit of a charcoal test meal, the doses inhibiting transit by 50% being respectively about 10 and 1 microgram/kg. These intestinal effects are opiate-specific, locally elicited and presumably involve the same act...

journal_title：Life sciences

authors： Manara L,Bianchi G,Fiocchi R,Notarnicola A,Peracchia F,Tavani A

更新日期：1982-09-20 00:00:00

abstract：:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lo...

journal_title：Life sciences

authors： Reid LD,Konecka AM,Przewłocki R,Millan MH,Millan MJ,Herz A

更新日期：1982-10-18 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently defined as the worst pandemic disease. SARS-CoV-2 infects human cells via the binding of its S protein to the receptor angiotensin-converting enzyme (ACE2). The use of ACEIs/ARBs (RAAS inhibitors) ...

journal_title：Life sciences

authors： Zhang J,Wang M,Ding W,Wan J

更新日期：2020-09-15 00:00:00

abstract：:Galectin-10 (gal-10, also known as Charcot-Leyden crystal protein) is a member of the galectin family of beta-galactoside binding proteins that is expressed uniquely in eosinophilic and basophilic leukocytes. To gain a better understanding of galectin gene expression, we present an analysis of the transcriptional regu...

journal_title：Life sciences

authors： Dyer KD,Rosenberg HF

更新日期：2001-06-01 00:00:00

abstract：AIMS:Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme that is shown to function as a gut mucosal defense factor, but its defensive mechanism remains unclear. The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic colitis in inte...

journal_title：Life sciences

authors： Lee C,Chun J,Hwang SW,Kang SJ,Im JP,Kim JS

更新日期：2014-04-01 00:00:00

abstract：:A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...

journal_title：Life sciences

authors： Moore RH 3rd,Dowling DA

更新日期：1982-10-11 00:00:00

abstract：:Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...

journal_title：Life sciences

authors： Martin BR

更新日期：2005-08-19 00:00:00

abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...

journal_title：Life sciences

authors： Kumar R,Yadav A,Pakrasi PL

更新日期：2017-02-01 00:00:00

abstract：:DCLHb, a hemoglobin based oxygen carrier, has been extensively studied for the treatment of hemorrhagic shock in both animal models and humans. Numerous accidents resulting in trauma are due to ethanol intoxication, in particular cases of car accidents. Therefore, trauma patients might be intoxicated with drugs of abu...

journal_title：Life sciences

authors： Palaparthy R,Saini BK,Gulati A

更新日期：2001-02-09 00:00:00

abstract：:Adenylate cyclase activity in pancreatic acinar cell membranes was determined in rats that had undergone a treatment with pentagastrin (250 micrograms/kg, intraperitoneal three times daily) for 1 week or that had undergone small bowel resection (90%) and were sacrified at 2 weeks, 1 month and 6 months after interventi...

journal_title：Life sciences

authors： Alvaro-Alonso I,Boyano-Adánez MC,Martín-Espinosa A,Arilla E

更新日期：1995-01-01 00:00:00

abstract：:Effects of intracellular accumulation of isoproterenol (ISO) on lactate production were examined in perfused rat heart. The lactate production during ISO perfusion in rat heart was increased and subsequent addition of an inhibitor of catechol-O-methyl transferase (COMT) further enhanced the production, and the enhance...

journal_title：Life sciences

authors： Kurahashi K,Akimoto Y,Inoue M,Kosakai K,Fujiwara M

更新日期：1990-01-01 00:00:00

abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...

journal_title：Life sciences

authors： Liu S,Zhai M,Xiao W,Zhou Q,Zhang D,Gong Y,Deng C,Liu C,Li L,He C

更新日期：2021-01-29 00:00:00

abstract：:The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...

journal_title：Life sciences

authors： Ogura J,Kobayashi M,Itagaki S,Hirano T,Iseki K

更新日期：2008-06-20 00:00:00