Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.

abstract：AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...

journal_title：Life sciences

authors： Beserra SS,Santos-Miranda A,Sarmento JO,Miranda VM,Roman-Campos D

更新日期：2020-08-15 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...

journal_title：Life sciences

authors： Genedani S,Bernardi M,Tagliavini S,Bertolini A

更新日期：1989-01-01 00:00:00

abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

journal_title：Life sciences

authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

更新日期：1987-05-25 00:00:00

abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...

journal_title：Life sciences

authors： Kashihara K,Sakai K,Marui K,Shohmori T

更新日期：1998-01-01 00:00:00

abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...

journal_title：Life sciences

authors： Xu M,Zhang Y,Dong W,Jiang L,Zhang J,Yu P,Xie S,Zhou L

更新日期：2018-05-15 00:00:00

abstract：:Ribonucleotide reductase is the rate limiting enzyme of de novo DNA synthesis; its activity is significantly increased in tumor cells related to the proliferation rate. Therefore the enzyme is considered to be an excellent target for cancer chemotherapy. In the present study we tested the in vitro and in vivo antitumo...

journal_title：Life sciences

authors： Fritzer-Szekeres M,Novotny L,Romanova D,Göbl R,Sedlak J,Vachalkova A,Rauko P,Elford HL,Szekeres T

更新日期：1998-01-01 00:00:00

abstract：:High salt intake is involved in the genesis of hypertension and vascular changes in salt-sensitive patients. Although many mechanisms have been proposed, the underlying mechanisms of these alterations in healthy rats are not completely elucidated. The aim of this study was to investigate if male Wistar rats fed a high...

journal_title：Life sciences

authors： dos Santos L,Gonçalves MV,Vassallo DV,Oliveira EM,Rossoni LV

更新日期：2006-04-04 00:00:00

abstract：AIMS:Chemerin has been recently identified as a vasoactive adipokine implicated in blood pressure regulation. In this context, we evaluated whether chemerin could influence pulmonary vasoreactive response. MATERIALS AND METHODS:Vascular reactivity to chemerin and to phenylephrine, serotonin and endothelin-1 after chem...

journal_title：Life sciences

authors： Hanthazi A,Jespers P,Vegh G,Degroot GN,Springael JY,Lybaert P,Dewachter L,Mc Entee K

更新日期：2019-08-15 00:00:00

abstract：:Myelin basic protein and phosphatidylinositol-4-phosphate are phosphorylated in vitro by ATP and solubilized rat brain myelin. When both substrates are present together, the rate of phosphorylation of each is increased about eight-fold. It appears likely that the phosphate turnover of myelin basic protein and of phosp...

journal_title：Life sciences

authors： Deshmukh DS,Kuizon S,Brockerhoff H

更新日期：1984-01-16 00:00:00

abstract：AIMS:LexA protein is a transcriptional repressor which regulates the expression of more than 60 genes belonging to the SOS global regulatory network activated by damages to bacterial DNA. Considering its role in bacteria, LexA represents a key target to counteract bacterial resistance: the possibility to modulate SOS r...

journal_title：Life sciences

authors： Bellio P,Mancini A,Di Pietro L,Cracchiolo S,Franceschini N,Reale S,de Angelis F,Perilli M,Amicosante G,Spyrakis F,Tondi D,Cendron L,Celenza G

更新日期：2020-01-15 00:00:00

abstract：:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...

journal_title：Life sciences

authors： Aft RL,Mueller GC

更新日期：1985-06-03 00:00:00

abstract：AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...

journal_title：Life sciences

authors： Pinho CA,Tromm CB,Tavares AM,Silva LA,Silveira PC,Souza CT,Benetti M,Pinho RA

更新日期：2012-04-09 00:00:00

abstract：:Phospholipid-sensitive Ca2+-dependent protein kinase and its endogenous substrate proteins were examined in acinar cells from rat pancreas. The enzyme was clearly demonstrable by DEAE-cellulose chromatography of acinar cell extract. At least four endogenous substrate proteins (Mr = 38K, 30K, 22K and 15K) for this Ca2+...

journal_title：Life sciences

authors： Wrenn RW

更新日期：1983-05-16 00:00:00

abstract：AIMS:Thrombin is a serine proteinase that is not only involved in coagulation cascade, but also mediates a number of biological responses relevant to tissues repair, and induces bronchoconstriction. TGF-β plays a pivotal role in airway remodeling due to its effects on airway smooth muscle proliferation and extracellula...

journal_title：Life sciences

authors： Yao ZH,Xie HJ,Yuan YL,Huo YT,Cao J,Lai WY,Cai RJ,Cheng YX

更新日期：2018-03-15 00:00:00

abstract：:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...

journal_title：Life sciences

authors： Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

更新日期：1999-01-01 00:00:00

abstract：AIMS:Microvascular endothelial cell dysfunction is a leading cause of radiation-induced heart disease (RIHD). BRCA1 plays an important role in DNA damage repair. The study aims to explore the effect of BRCA1 in endothelial cells involved in RIHD. MATERIALS AND METHODS:BRCA1 and p21 expression were detected in human um...

journal_title：Life sciences

authors： Zeng ZM,Du HY,Xiong L,Zeng XL,Zhang P,Cai J,Huang L,Liu AW

更新日期：2020-03-01 00:00:00

abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...

journal_title：Life sciences

authors： Chen J,Tan L,Liao Y,Long J,Zhou Y,Wei J,Zhou Y

更新日期：2020-08-15 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：:The inhibitory effect of some isoxazolpyrimidine derivatives on iNOS and COX-2 endotoxin induction in mouse peritoneal macrophages has been studied. Three of these compounds inhibited nitrite and PGE2 accumulation in a concentration dependent-manner at microM range. None of these active compounds affected iNOS, COX-2,...

journal_title：Life sciences

authors： Vidal A,Ferrándiz ML,Ubeda A,Guillén I,Riguera R,Quintela JM,Peinador C,Moreira MJ,Alcaraz MJ

更新日期：2000-01-21 00:00:00

abstract：:The in vitro and in vivo regulation of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors (PBR) by ion transport/exchange inhibitors was studied in the kidney. The potencies of 9-anthroic acid, furosemide, bumetanide, hydrochlorothiazide and SITS as inhibitors of [3H]Ro 5-4864 binding to renal membranes were...

journal_title：Life sciences

authors： Basile AS,Lueddens HW,Skolnick P

更新日期：1988-01-01 00:00:00

abstract：:Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...

journal_title：Life sciences

authors： Fujita K,Mogami A,Hayashi A,Kamataki T

更新日期：2000-04-07 00:00:00

abstract：:A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and...

journal_title：Life sciences

authors： Mereu G,Corda MG,Carcangiu P,Giorgi O,Biggio G

更新日期：1987-04-06 00:00:00

abstract：AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...

journal_title：Life sciences

authors： Abareshi A,Hosseini M,Beheshti F,Norouzi F,Khazaei M,Sadeghnia HR,Boskabady MH,Shafei MN,Anaeigoudari A

更新日期：2016-12-15 00:00:00

abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

journal_title：Life sciences

authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

更新日期：1997-01-01 00:00:00

abstract：:We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...

journal_title：Life sciences

authors： Bernardini R,Calogero AE,Mauceri G,Chrousos GP

更新日期：1990-01-01 00:00:00

abstract：:The microscopic localization of angiotensin II receptors in the rat brainstem has been accomplished utilizing in vitro receptor autoradiographic techniques. These receptors are highly localized to discrete nuclear regions of the brainstem. Significant densities of autoradiographic grains, indicating the presence of sp...

journal_title：Life sciences

authors： Gehlert DR,Speth RC,Healy DP,Wamsley JK

更新日期：1984-04-16 00:00:00

abstract：:5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with alpha-methyl 5-HT or prostaglandin F2 alpha. Relaxation was not blocked by propranolol (1 micron), atropine (1 micron), indomethacin (3 microns), mepyramine (1 micron), cimetidine (1 micron), o...

journal_title：Life sciences

authors： Trevethick MA,Feniuk W,Humphrey PP

更新日期：1984-07-30 00:00:00

abstract：:A fostering/crossfostering analysis of the effects of maternal ethanol exposure on jejunal and ileal folate absorption was performed. Male and female rats were randomized into two groups. In the first group, ethanol-treated rats received ad libitum 5, 10 and 15% ethanol in the drinking fluid during three successive we...

journal_title：Life sciences

authors： Murillo-Fuentes ML,Murillo ML,Carreras O

更新日期：2003-09-12 00:00:00

abstract：:Autophagy is a metabolic process that maintains the homeostasis of the intracellular environment by degrading damaged proteins and organelles in lysosomes. Recently, independent studies have indicated that some hepatitis viruses develop abilities to hijack autophagy for their replication, such as hepatitis B (HBV) and...

journal_title：Life sciences

authors： Zhang L

更新日期：2020-02-01 00:00:00

abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

journal_title：Life sciences

authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

更新日期：2020-09-01 00:00:00