Abstract：
:The inhibitory effect of some isoxazolpyrimidine derivatives on iNOS and COX-2 endotoxin induction in mouse peritoneal macrophages has been studied. Three of these compounds inhibited nitrite and PGE2 accumulation in a concentration dependent-manner at microM range. None of these active compounds affected iNOS, COX-2, COX-1 or PLA2 activities, although some reduced iNOS or COX-2 expression. Besides, no effect was observed on human neutrophil inflammatory responses (LTB4 biosynthesis and superoxide or elastase release). Active compounds were assayed by oral administration in the mouse air pouch model, where they inhibited nitrite accumulation without affecting PGE2 levels or leukocyte migration.
journal_name
Life Scijournal_title
Life sciencesauthors
Vidal A,Ferrándiz ML,Ubeda A,Guillén I,Riguera R,Quintela JM,Peinador C,Moreira MJ,Alcaraz MJdoi
10.1016/s0024-3205(99)00658-xsubject
Has Abstractpub_date
2000-01-21 00:00:00pages
PL125-31issue
9eissn
0024-3205issn
1879-0631pii
S002432059900658Xjournal_volume
66pub_type
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