Abstract：
:A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and benzodiazepines. ZK 93423 (0.05-1.0 mg/kg) inhibited reticulata cells in a dose-related manner up to the cessation of their activity. Since the maximal rate-inhibition elicited by diazepam (1.0 mg/kg) was some 55% of baseline, ZK 93423 showed a much greater potency. Moreover, the firing depression by ZK 93423 was prevented and reversed by two benzodiazepine receptor antagonists: Ro15-1788 and ZK 93426. However, the dosage of Ro15-1788 required for these actions was at least five times higher than that for the blockade of the diazepam effect. The results indicate that the beta-carboline agonist ZK 93423 decreases the activity of reticulata neurons more effectively than diazepam.
journal_name
Life Scijournal_title
Life sciencesauthors
Mereu G,Corda MG,Carcangiu P,Giorgi O,Biggio Gdoi
10.1016/0024-3205(87)90333-xsubject
Has Abstractpub_date
1987-04-06 00:00:00pages
1423-30issue
14eissn
0024-3205issn
1879-0631pii
0024-3205(87)90333-Xjournal_volume
40pub_type
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