Effect of dietary nitric oxide on gastric mucosal mast cells in absence or presence of an experimental gastritis in rats.

abstract：:[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degre...

journal_title：Life sciences

authors： Andorn AC,Huang EH,Warren AE

更新日期：1984-06-18 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：:The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices. Field potentials were evoked by stimulation of Schaffer collaterals, and recorded from the CA1 region of the hippocampus after infusion of 4-AP in the absence an...

journal_title：Life sciences

authors： Camacho-Ochoa M,VonVoigtlander PF,Hoffmann WE,Piercey MP

更新日期：1992-01-01 00:00:00

abstract：AIM:This study investigated the effect of voluntary motor effort during a low-intensity (30% maximal voluntary contraction [MVC]) muscle exercise training program on increasing muscle strength. MATERIALS AND METHODS:Eighteen young and healthy individuals were randomly assigned to one of three groups: high mental effor...

journal_title：Life sciences

authors： Jiang CH,Ranganathan VK,Siemionow V,Yue GH

更新日期：2017-06-01 00:00:00

abstract：AIMS:In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analgesics in rats with painful diabetic neuropathy. Using mic...

journal_title：Life sciences

authors： Suehiro K,Funao T,Fujimoto Y,Yamada T,Mori T,Nishikawa K

更新日期：2013-06-21 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：:Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of i...

journal_title：Life sciences

authors： Núñez MJ,Fernández-Rial JC,Couceiro J,Suárez JA,Gómez-Fernández DE,Rey-Méndez M,Freire-Garabal M

更新日期：1993-01-01 00:00:00

abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

journal_title：Life sciences

authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

更新日期：2020-07-15 00:00:00

abstract：:In an attempt to investigate the role of nucleoside transporter function in the hypertensive state, we have compared the binding of [3H]nitrobenzylthioinosine ([3H]NBMPR), a nucleoside transporter probe, in membranes prepared from platelet, renal, pulmonary, cardiac and brain tissues of spontaneously hypertensive rats...

journal_title：Life sciences

authors： Williams EF,Udofia UP,Brooks GR,Hawk NN

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of lipoxin A4 (LXA4) on inflammatory responses in obesity-related glomerulopathy (ORG) mouse model and its potential mechanisms. METHODS:Male C57BL/6 mice were randomly divided into 4 groups: normal, model, LXA4, and LXA4/Boc-2 groups (n = 8). Mice in LXA4 group were intraperitone...

journal_title：Life sciences

authors： Guo YP,Jiang HK,Jiang H,Tian HY,Li L

更新日期：2018-04-01 00:00:00

abstract：:Purification of endothelin converting enzyme (ECE) from endothelial cells has been hindered by the difficulty in obtaining primary endothelial cells in large quantity. We therefore tested transformed human umbilical vein endothelial cells (EA.hy926) for ECE activity. Our data clearly demonstrate that this transformed ...

journal_title：Life sciences

authors： Ahn K,Pan S,Beningo K,Hupe D

更新日期：1995-01-01 00:00:00

abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...

journal_title：Life sciences

authors： Bharadwaj S,Lee KE,Dwivedi VD,Kang SG

更新日期：2020-09-15 00:00:00

abstract：:This study was designed to evaluate the effects of roxithromycin (RXM), a newly synthesized macrolide antibiotic on allergic responses in mice. RXM was orally administered into BALB/c mice once a day for 42 days in a single dose of 5 mg/kg body weight. Spleen cells (Sp C) collected from mice on day 7, 14, 28 and 42 po...

journal_title：Life sciences

authors： Konno S,Adachi M,Asano K,Okamoto K,Takahashi T

更新日期：1993-01-01 00:00:00

abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

journal_title：Life sciences

authors： Bektas N,Arslan R,Ozturk Y

更新日期：2014-01-24 00:00:00

abstract：AIMS:Oxidative stress has been largely implicated in the pathogenesis of anoxia/reoxygenation injury. Ganoderma atrum polysaccharide (PSG-1), the most abundant component extracted from the fruiting bodies of G. atrum, has been shown to possess potent antioxidant activity. In this study, we investigated whether PSG-1 at...

journal_title：Life sciences

authors： Li WJ,Nie SP,Yan Y,Zhu SB,Xie MY

更新日期：2009-10-21 00:00:00

abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

journal_title：Life sciences

authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

更新日期：2003-02-07 00:00:00

abstract：AIMS:Insulin-like growth factor (IGF)-1 is a major mitogenic growth factor for mesangial cells (MCs). Statins slow the progression of chronic kidney disease by affecting inflammatory cell signaling pathways, in addition to improving lipid profile, however, no studies have investigated the effects of fluvastatin on mito...

journal_title：Life sciences

authors： Shibata T,Tamura M,Kabashima N,Serino R,Tokunaga M,Matsumoto M,Miyamoto T,Miyazaki M,Furuno Y,Takeuchi M,Abe H,Okazaki M,Otsuji Y

更新日期：2009-05-22 00:00:00

abstract：AIMS:Forkhead box (FOX) proteins constitute a huge family of transcriptional regulators, which are involved in a wide range of cancers. FOXK1 is a little studied member of FOXK subfamily. This study aimed to investigate the potential prognostic value of FOXK1 in human hepatocellular carcinoma (HCC) and explore potentia...

journal_title：Life sciences

authors： Cao H,Chu X,Wang Z,Guo C,Shao S,Xiao J,Zheng J,Zhang D

更新日期：2019-07-01 00:00:00

abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

journal_title：Life sciences

authors： Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

更新日期：2007-09-08 00:00:00

abstract：AIMS:Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and the mechanisms of actions are unclear. In this work, we evaluated its...

journal_title：Life sciences

authors： Sun S,Yang F,Zhu Y,Zhang S

更新日期：2020-12-01 00:00:00

abstract：:2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...

journal_title：Life sciences

authors： Schiller PW,Weltrowska G,Nguyen TM,Lemieux C,Chung NN,Lu Y

更新日期：2003-06-27 00:00:00

abstract：:Cold acclimation increases the thermogenic capacity of brown adipose tissue (BAT) and this is associated with both a general hypertrophy of the tissue and a selective increase in the proportion of a specific 32,000 molecular weight, GDP-binding protein in the mitochondrial membrane. This protein regulates the activity...

journal_title：Life sciences

authors： Young P,Wilson S,Arch JR

更新日期：1984-03-19 00:00:00

abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

journal_title：Life sciences

authors： Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

更新日期：2015-08-01 00:00:00

abstract：UNLABELLED:The mechanisms by which exercise affects atherosclerotic plaque stability remain incompletely understood. We evaluated the effects of two training protocols on both atherosclerotic plaque structure and the signaling pathways involved in plaque rupture. METHODS:Male low-density lipoprotein (LDL) receptor kno...

journal_title：Life sciences

authors： Cardinot TM,Lima TM,Moretti AI,Koike MK,Nunes VS,Cazita PM,Krieger MH,Brum PC,Souza HP

更新日期：2016-05-15 00:00:00

abstract：:Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...

journal_title：Life sciences

authors： Kawaguchi Y,Ikegami H,Fukuda M,Takekawa K,Fujioka Y,Fujisawa T,Ueda H,Ogihara T

更新日期：1994-01-01 00:00:00

abstract：:Renal failure (RF) has been shown to alter intestinal transport of a number of nutrients. We studied jejunal absorption of pyridoxine (B6) in rats rendered azotemic by subtotal nephrectomy (RF group) and compared the results with those obtained in normal rats subjected to sham operation (controls) and animals pair-fed...

journal_title：Life sciences

authors： Barbari A,Vaziri ND,Benavides I,Chen YT,Said H,Pahl MV

更新日期：1989-01-01 00:00:00

abstract：:Nitric oxide (NO) is a highly reactive free radical that is involved in a variety of different biological process. In recent reports, the putative role of NO in the neuropathogenesis of brain inflammation has been demonstrated. And then the relation between neuronal NO and convulsive seizures induced by virus has been...

journal_title：Life sciences

authors： Kawashima H,Inage Y,Ogihara M,Kashiwagi Y,Takekuma K,Hoshika A,Mori T,Watanabe Y

更新日期：2004-01-30 00:00:00

abstract：:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...

journal_title：Life sciences

authors： Moreno DA,Ilic N,Poulev A,Raskin I

更新日期：2006-05-08 00:00:00

abstract：:The loss of osteoblast function in aging bone is one of the major causes of osteopenia, or loss of bone mass. In this study, this loss of function was investigated by examining the proliferative response of rat long bone periosteal osteoblasts to TGF(beta1) and 1,25-dihydroxy vitamin D(3) (1,25-D(3)) as a function of ...

journal_title：Life sciences

authors： Shiels MJ,Mastro AM,Gay CV

更新日期：2002-05-10 00:00:00