Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 correlate with progression in human neuroblastoma.

abstract：:Glial cells are currently viewed as active partners of neurons in synapse formation. The close proximity of astrocytes to the synaptic cleft implicates that they strongly influence synapse function as well as suggests that these cells might be potential targets for neuronal-released molecules. In this review, we discu...

journal_title：Life sciences

authors： Stipursky J,Romão L,Tortelli V,Neto VM,Gomes FC

更新日期：2011-10-10 00:00:00

abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

journal_title：Life sciences

authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

更新日期：2016-01-01 00:00:00

abstract：:The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats w...

journal_title：Life sciences

authors： Nihei T,Miura Y,Yagasaki K

更新日期：2001-05-11 00:00:00

abstract：:Glucocorticoids (GCs) are hormones with anti-inflammatory and immuno-suppressive effects. The use of hormonal medicine like GCs may cause systemic adverse effects. In the present study, the cellular response of murine pre-osteoclast cell line RAW264.7 to dexamethasone (DEX) was investigated and the result demonstrated...

journal_title：Life sciences

authors： Zhang Q,Fong CC,Zhang Y,Tzang CH,Fong WF,Yang M

更新日期：2008-01-16 00:00:00

abstract：:The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...

journal_title：Life sciences

authors： Basu S,Chaudhuri T,Chauhan SP,Das Gupta AK,Chaudhury L,Vedasiromoni JR

更新日期：2005-05-13 00:00:00

abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...

journal_title：Life sciences

authors： El Golli N,Dkhili H,Dallagi Y,Rahali D,Lasram M,Bini-Dhouib I,Lebret M,Rosa JP,El Fazaa S,Allal-El Asmi M

更新日期：2016-02-01 00:00:00

abstract：:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...

journal_title：Life sciences

authors： Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K

更新日期：2004-08-13 00:00:00

abstract：:Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...

journal_title：Life sciences

authors： Chen TH,Huang HP,Matsumoto Y,Wu SH,Wang MF,Chung SY,Uezu K,Moriyama T,Uezu E,Korin T,Sato S,Yamamoto S

更新日期：1996-01-01 00:00:00

abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...

journal_title：Life sciences

authors： Shukla GS,Hussain T,Chandra SV

更新日期：1987-11-09 00:00:00

abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...

journal_title：Life sciences

authors： Yanagida M,Gohda E,Yamamoto I

更新日期：1996-01-01 00:00:00

abstract：AIMS:Idiopathic pulmonary fibrosis continues to be a devastating clinical disorder for which there are few therapeutic options, and the pathogenesis of this disease remains largely unknown. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in cholesterol biosynthesis, and they have been reported...

journal_title：Life sciences

authors： Oka H,Ishii H,Iwata A,Kushima H,Toba S,Hashinaga K,Umeki K,Tokimatsu I,Hiramatsu K,Kadota J

更新日期：2013-12-18 00:00:00

abstract：AIMS:Tet1, Tet2, and interleukin-6 (IL-6) have been linked to atherosclerosis. Whether Tet3 has a relationship with atherosclerosis and IL-6 was unknown. This study aims to determine the link between Tet3 and IL-6, and the role of Tet3 in prenatal hypoxia-induced atherosclerosis in offspring rats. MAIN METHODS:Pregnan...

journal_title：Life sciences

authors： Zhang P,Chen X,Zhang Y,Su H,Zhang Y,Zhou X,Sun M,Li L,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

journal_title：Life sciences

authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

更新日期：2004-03-26 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

journal_title：Life sciences

authors： Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

更新日期：2007-09-08 00:00:00

abstract：:Data reviewed here indicate that acute and chronic ethanol ingestion induce a decrease in the concentration of GSH and an increase in lipoperoxidation in the liver both in experimental animals and in man, changes that are closely interrelated GSH depletion is suggested to be due to an oxidation in the liver tissue and...

journal_title：Life sciences

authors： Videla LA,Valenzuela A

更新日期：1982-11-29 00:00:00

abstract：:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...

journal_title：Life sciences

authors： Sindhu RK,Roberts CK,Ehdaie A,Zhan CD,Vaziri ND

更新日期：2005-01-07 00:00:00

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：:We studied the effects of arachidonic acid (AA) on Cl secretion across primary cultures of dog tracheal epithelium. Cell sheets showed mean values for baseline short-circuit current (Isc) and transepithelial resistance of 33.8 muA/cm2 and 360 omega.cm2 (n = 44). AA (5 x 10(-5) M) added to both sides increased Isc by 2...

journal_title：Life sciences

authors： Mochizuki H,Chao AC,Widdicombe JH

更新日期：1992-01-01 00:00:00

abstract：:Human, dog and rabbit corpus cavernosum type 5 phosphodiesterases (PDE5) were isolated and their characteristics were compared. The three enzymes showed Km values of 0.8, 2.1 and 2.3 uM, respectively. They exhibited similar pH-dependence with optimal pH being 7.5. They required Mg++ for activity and the activity was s...

journal_title：Life sciences

authors： Wang P,Wu P,Myers JG,Stamford A,Egan RW,Billah MM

更新日期：2001-03-16 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...

journal_title：Life sciences

authors： Benschop RJ,Jabaaij L,Oostveen FG,Vingerhoets AJ,Kirschbaum C,Duivenvoorden HJ,Ballieux RE

更新日期：1993-01-01 00:00:00

abstract：:We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 produ...

journal_title：Life sciences

authors： Funaki N,Arii S,Adachi Y,Higashituji H,Tanaka J,Imamura M

更新日期：1993-01-01 00:00:00

abstract：:The effect of anti beta adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after beta adrenoceptor blockade or after the absorption of...

journal_title：Life sciences

authors： Pascual J,Borda E,Sterin-Borda L

更新日期：1987-01-26 00:00:00

abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist...

journal_title：Life sciences

authors： Leung FW,Iwata F,Kao J,Seno K,Itoh M,Leung JW

更新日期：2002-01-04 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...

journal_title：Life sciences

authors： Kanno S,Shouji A,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Obara Y,Nakahata N,Ishikawa M

更新日期：2006-01-11 00:00:00

abstract：:Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...

journal_title：Life sciences

authors： Huang YC,Guh JH,Teng CM

更新日期：2004-05-21 00:00:00

abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...

journal_title：Life sciences

authors： Sakurai T,Inagaki N,Nagai H

更新日期：1994-01-01 00:00:00