Neuron-glia signaling: Implications for astrocyte differentiation and synapse formation.

abstract：AIMS:Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old. In a preliminary study, HA-WKY but not WKY/Izm showed hyperinsulinemia and severe hypercholesterolemia whe...

journal_title：Life sciences

authors： Inoue T,Takemori K,Yamamoto K,Ito H

更新日期：2010-02-27 00:00:00

abstract：:The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed sub...

journal_title：Life sciences

authors： van Ree JM

更新日期：1983-12-05 00:00:00

abstract：:Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...

journal_title：Life sciences

authors： Tien XY,Wahawisan R,Wallace LJ,Gaginella TS

更新日期：1985-05-20 00:00:00

abstract：:Purification of endothelin converting enzyme (ECE) from endothelial cells has been hindered by the difficulty in obtaining primary endothelial cells in large quantity. We therefore tested transformed human umbilical vein endothelial cells (EA.hy926) for ECE activity. Our data clearly demonstrate that this transformed ...

journal_title：Life sciences

authors： Ahn K,Pan S,Beningo K,Hupe D

更新日期：1995-01-01 00:00:00

abstract：AIM:To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS:NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This c...

journal_title：Life sciences

authors： Sreeja S,Krishnan Nair CK

更新日期：2018-02-15 00:00:00

abstract：:The present study attempts to indirectly determine if a neuronal cannabinoid (CB1) receptor mediates the intraocular pressure (IOP) reduction effects of arachidonoyl ethanolamide (AEA), its R-alpha-isopropyl analog, and the non-classical cannabinoid, CP-55,940. A series of these cannabinoids were dissolved in an aqueo...

journal_title：Life sciences

authors： Pate DW,Järvinen K,Urtti A,Mahadevan V,Järvinen T

更新日期：1998-01-01 00:00:00

abstract：:Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase incr...

journal_title：Life sciences

authors： José HJ,Berenice SG,Cecilia VR

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...

journal_title：Life sciences

authors： Greige-Gerges H,Abou Khalil R,Chahine R,Haddad C,Harb W,Ouaini N

更新日期：2007-01-16 00:00:00

abstract：:Two male adult rhesus monkeys were used and caged individually. The room was temperature-controlled having a light-dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45 and 60 mins after the k...

journal_title：Life sciences

authors： Mora OA,García Castiñeiras S,Ezquerra C,Guisado S

更新日期：1991-01-01 00:00:00

abstract：:Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weigh...

journal_title：Life sciences

authors： Figueroa J,Vijayagopal P,Debata C,Prasad A,Prasad C

更新日期：1999-01-01 00:00:00

abstract：:Hyperforin is the major active ingredient of Hypericum perforatum (St John's Wort), a traditional antidepressant medication. This study evaluated its inhibitory effects on the synaptic uptake of monoamines in rat forebrain homogenates, comparing the nature of the inhibition at synaptic and vesicular monoamine transpor...

journal_title：Life sciences

authors： Roz N,Mazur Y,Hirshfeld A,Rehavi M

更新日期：2002-09-27 00:00:00

abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...

journal_title：Life sciences

authors： Zagon IS,Hurst WJ,McLaughlin PJ

更新日期：1998-01-01 00:00:00

abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...

journal_title：Life sciences

authors： Uchizono Y,Takeya R,Iwase M,Sasaki N,Oku M,Imoto H,Iida M,Sumimoto H

更新日期：2006-12-14 00:00:00

abstract：:Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake1). There are reports which describe the activity of uptake1 being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a m...

journal_title：Life sciences

authors： Gliese M,Babin-Ebell J,Schömig E,Russ H

更新日期：1994-01-01 00:00:00

abstract：:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...

journal_title：Life sciences

authors： Aft RL,Mueller GC

更新日期：1985-06-03 00:00:00

abstract：:Physalis angulata and P. peruviana are herbs widely used in folk medicine. In this study, the aqueous and ethanol extracts prepared from the whole plant of these species were evaluated for their antihepatoma activity. Using XTT assay, three human hepatoma cells, namely Hep G2, Hep 3B and PLC/PRF/5 were tested. The res...

journal_title：Life sciences

authors： Wu SJ,Ng LT,Chen CH,Lin DL,Wang SS,Lin CC

更新日期：2004-03-05 00:00:00

abstract：:Dopamine inhibited basal, TRH-, IBMX- and A23187-stimulated prolactin secretion from rat anterior pituitary cells. However, dopamine did not inhibit prolactin secretion stimulated by elevated K+ concentrations. These data are interpreted in terms of dopaminergic inhibition of both cyclic AMP production and Ca2+ influx...

journal_title：Life sciences

authors： Merritt JE,Brown BL

更新日期：1984-08-13 00:00:00

abstract：:Recent reports indicate that some imidazole-5-acetic acid derivatives are competitive antagonists of angiotensin II receptors. However, to our knowledge, there is no published information regarding: 1) what constant infusion rate of these non-peptide angiotensin receptor blockers is necessary to effectively antagonize...

journal_title：Life sciences

authors： Jackson EK,Inagami T

更新日期：1990-01-01 00:00:00

abstract：:Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. However, little is known of the molecular action of these hormones in conditions of hyperthyroidism a...

journal_title：Life sciences

authors： Olímpio RMC,Moretto FCF,De Sibio MT,de Oliveira M,Mathias LS,Gonçalves BM,Deprá IC,Tilli HP,Rodrigues BM,Saraiva PP,Maria DA,Nogueira CR

更新日期：2019-08-15 00:00:00

abstract：:Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...

journal_title：Life sciences

authors： Kumar A,Upadhyay G,Modi DR,Singh MP

更新日期：2007-11-30 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

journal_title：Life sciences

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:The antinociceptive and temperature responses to morphine were compared in male and female rats from two different strains. Males of both the Sprague-Dawley and Wistar-Furth strains were slightly more responsive to the acute actions of morphine than were females of the same strain. However, Wistar-Furth animals requir...

journal_title：Life sciences

authors： Kasson BG,George R

更新日期：1984-04-23 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel numb...

journal_title：Life sciences

authors： Ribatti D,Surico G,Vacca A,De Leonardis F,Lastilla G,Montaldo PG,Rigillo N,Ponzoni M

更新日期：2001-01-26 00:00:00

abstract：AIMS:Aristolochic acid (AA) nephrotoxicity is related to accumulation of methylglyoxal (MGO) and N(ε)-(carboxymethyl)lysine (CML) in the mouse kidney. We studied the activity of renal semicarbazide-sensitive amine oxidase (SSAO), a key enzyme involved in MGO generation, in AA-treated mice, and investigated nephroprotec...

journal_title：Life sciences

authors： Huang TC,Chen SM,Li YC,Lee JA

更新日期：2014-09-26 00:00:00

abstract：:We report that both Na+ and Ca2+ currents are involved in the action potentials and in the hormone release from rat somatotrophs in primary culture. Single somatotrophs were identified by reverse hemolytic plaque assay (RHPA) and transmembrane voltage and currents were recorded using the whole-cell mode of the patch-c...

journal_title：Life sciences

authors： Chen C,Zhang J,Vincent JD,Israel JM

更新日期：1990-01-01 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an adhesion molecule of the immunoglobulin superfamily, has been characterized as a putative tumor suppressor because it is frequently down-regulated in aggressive types of cancer cells. Recently, however, several studies have shown that CEACAM1 acti...

journal_title：Life sciences

authors： Hokari M,Matsuda Y,Wakai T,Shirai Y,Sato M,Tsuchiya A,Takamura M,Yamagiwa S,Suzuki K,Ohkoshi S,Ichida T,Kawachi H,Aoyagi Y

更新日期：2007-07-04 00:00:00

abstract：:Normal mammary gland growth and reproduction were examined in C3H/HeMei mice given caffeine as drinking water (500 mg/l tap water) after weaning on day 20 of age. Caffeine ingestion had little effects on any of the day of vaginal opening, body growth, pattern of estrous cycles, mammary gland growth and reproduction ex...

journal_title：Life sciences

authors： Nagasawa H,Sakurai N

更新日期：1986-07-28 00:00:00

abstract：AIMS:Porcelain-fused-to-metal (PFM) crowns are a standard restoration technique in dentistry, but toxicity of PFM in vivo has not been systematically evaluated. The present study evaluated the effects of various metal alloy shells of PFM crowns on the development of zebrafish embryos and larvae in order to determine th...

journal_title：Life sciences

authors： Zhao L,Si J,Wei Y,Li S,Jiang Y,Zhou R,Liu B,Zhang H

更新日期：2018-06-15 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently defined as the worst pandemic disease. SARS-CoV-2 infects human cells via the binding of its S protein to the receptor angiotensin-converting enzyme (ACE2). The use of ACEIs/ARBs (RAAS inhibitors) ...

journal_title：Life sciences

authors： Zhang J,Wang M,Ding W,Wan J

更新日期：2020-09-15 00:00:00