Abstract：
:The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed subcutaneously 1 h before each daily session. It was found that the opioid peptides alpha-, gamma- and beta-endorphin hardly influenced acquisition of heroin self-administration, while the non-opioid fragments of alpha- and gamma- endorphin modulated this behavioral response. In fact, beta-endorphin (beta E) 2-9 tended to facilitate the rate of acquisition, while the gamma-type endorphins, des-Tyr1-gamma-endorphin (beta E 2-17) and des-enkephalin-gamma-endorphin (beta E 6-17), decreased heroin intake. Concerning the ACTH/MSH related peptides, a decreasing effect of heroin intake was found following treatment with (D-Phe7)-ACTH 4-10, with a high dose of the ACTH 4-9 analog Org 2766 and with gamma 2-MSH, while ACTH 1-24, ACTH 4-10 and a low dose of Org 2766 did not significantly influence self-injecting behavior. It is concluded that pro-opiomelanocortin serves as a precursor molecule for peptide fragments, which modulate the acquisition of heroin self-administration in rats.
journal_name
Life Scijournal_title
Life sciencesauthors
van Ree JMdoi
10.1016/0024-3205(83)90261-8subject
Has Abstractpub_date
1983-12-05 00:00:00pages
2283-9issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(83)90261-8journal_volume
33pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibite...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.01.058
更新日期：2007-04-10 00:00:00
abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90218-g
更新日期：1990-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116930
更新日期：2019-11-15 00:00:00
abstract：:In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00088-4
更新日期：1996-01-01 00:00:00
abstract：:14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-reti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.08.027
更新日期：2005-02-18 00:00:00
abstract：:The mechanism of fibrate-induced myopathy was investigated in this report. When clofibrate (30 to 300 microM) was applied to L6 rat skeletal myoblasts, dose-dependently apoptosis was observed within 24 h. In the apoptotic myoblasts, a caspase-12 cleavage was observed at 2 h and with following caspases-9 and -3-related...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.08.003
更新日期：2006-03-13 00:00:00
abstract：:Although intraepithelial T lymphocytes of the large intestine (LI) are known to differ from those of the small intestine (SI) in phenotype and function, differences in LI and SI lamina propria (LP) lymphocyte populations have not been clearly established. In this work we found striking phenotypic differences between S...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.08.042
更新日期：2005-04-29 00:00:00
abstract：:Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90357-7
更新日期：1986-12-01 00:00:00
abstract：:Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable levels of the nNOS protein were evident in the SK-N-SH, SH-SY5Y, and N1E-115 neuroblastoma cell lines, as well as the NG108-15 neuroblastoma x glioma hybrid. Only...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01732-0
更新日期：2002-07-05 00:00:00
abstract：:Although several reports imply that anticoagulants and preservatives contain zinc, the quantity of zinc in heparin, if any, has not been documented. Zinc concentration was determined by flame atomic absorption spectroscopy in varying dilutions of multiple commercially obtained samples of purified sodium heparin N = 15...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90348-x
更新日期：1983-12-26 00:00:00
abstract：:We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00329-x
更新日期：1999-01-01 00:00:00
abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(95)00068-2
更新日期：1995-03-03 00:00:00
abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01507-2
更新日期：2002-04-05 00:00:00
abstract：:The effects of erythropoietin (EPO) on cytosolic free calcium concentration ([Ca2+]i) in platelets of 20 essential hypertensive patients (HT) and of 25 normotensive subjects (NT) were investigated using the fura2 technique. In resting platelets [Ca2+]i were not significantly higher in HT compared to NT (74.3 +/- 7.8 n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90010-m
更新日期：1992-01-01 00:00:00
abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90792-0
更新日期：1983-08-01 00:00:00
abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90593-z
更新日期：1991-01-01 00:00:00
abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.01.033
更新日期：2015-05-01 00:00:00
abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90331-7
更新日期：1989-01-01 00:00:00
abstract：AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.02.018
更新日期：2011-04-25 00:00:00
abstract：:Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00689-5
更新日期：2000-07-14 00:00:00
abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.03.018
更新日期：2007-05-16 00:00:00
abstract：:Clinical reports suggest that EGFR-mutated lung cancer usually respond significantly towards small molecule tyrosine kinase inhibitors. Same studies also report the eventual development of acquired resistance within a median time interval of 9 to 14months. One of the major mechanisms involved in this acquired resistan...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2017.08.001
更新日期：2017-10-01 00:00:00
abstract：AIMS:Cancer Stem Cells (CSCs) refers to heterogeneous tumor cells retaining the abilities of self-renewal and differentiation. This study used mRNAsi, which is an index to describe the similarity between tumor cells and CSCs, to define genes involved in endometrial carcinoma. MATERIALS AND METHODS:The mRNA expression ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118231
更新日期：2020-10-01 00:00:00
abstract：:Meso-dimercaptosuccinic acid (DMSA) and the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) are analogous in chemical structure to dimercaprol (BAL, British Anti-Lewisite). Dimercaprol was among the first therapeutically useful metal chelating agents and was developed originally as an anti-lewisite agent. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90108-4
更新日期：1982-11-08 00:00:00
abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00107-0
更新日期：1997-01-01 00:00:00
abstract：:The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nuc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02287-7
更新日期：2002-12-20 00:00:00
abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(92)90201-y
更新日期：1992-01-01 00:00:00
abstract：:Mast cells were originally considered wandering histiocytes, but are now known to derive from the bone marrow and enter the tissues as immature or precursor cells which then differentiate under micro-environmental influences such as interleukin-3. At least three types of mature mast cells have been identified as seros...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(90)90129-f
更新日期：1990-01-01 00:00:00
abstract：:The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, I have shown that myricetin exhibits a significant induction of different...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.026
更新日期：2005-10-21 00:00:00
abstract：:Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.08.018
更新日期：2006-03-06 00:00:00
