Abstract:
:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibited by L-N(G)-nitro arginine methyl ester (L-NAME), suggesting that nitric oxide (NO) contributes to the SNTX-induced response. Interestingly, D, L-proparglyglycine (PAG) and beta-cyano-L-alanine (BCA), irreversible and competitive inhibitors of cystathionine-gamma-lyase (CSE) respectively, also inhibited SNTX-induced vasorelaxation, indicating that H(2)S may also play a part in the effect of SNTX. The combined use of L-NAME with PAG or BCA showed that H(2)S and NO act synergistically in effecting SNTX-induced vasorelaxation.
journal_name
Life Scijournal_title
Life sciencesauthors
Liew HC,Khoo HE,Moore PK,Bhatia M,Lu J,Moochhala SMdoi
10.1016/j.lfs.2007.01.058subject
Has Abstractpub_date
2007-04-10 00:00:00pages
1664-8issue
18eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00100-2journal_volume
80pub_type
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