Discriminative and aversive properties of beta-carboline-3-carboxylic acid ethyl ester, a benzodiazepine receptor inverse agonist, in rhesus monkeys.

abstract：:The effect of gonadal steroids on the response to analgesia testing was determined in castrated male and female rats and castrated male and female rats treated with testosterone propionate (TP) and estradiol benzoate (EB), respectively. The time to respond to a noxious somatic stimulus in the form of heat was assessed...

journal_title：Life sciences

authors： Forman LJ,Tingle V,Estilow S,Cater J

更新日期：1989-01-01 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS:We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reac...

journal_title：Life sciences

authors： Tanimoto N,Kumon Y,Suehiro T,Ohkubo S,Ikeda Y,Nishiya K,Hashimoto K

更新日期：2003-05-09 00:00:00

abstract：:Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the sec...

journal_title：Life sciences

authors： Rocha LT,Costa KA,Oliveira AC,Nascimento EB Jr,Bertollo CM,Araújo F,Teixeira LR,Andrade SP,Beraldo H,Coelho MM

更新日期：2006-06-27 00:00:00

abstract：AIMS:7-Ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxidized low-density lipoprotein (oxLDL), has been reported to be a crucial ligand of beta2-glycoprotein I (β(2)-GPI), and plays a potential role in the development of atherosclerosis (AS), however, the role of the sole oxLig-1 in the development of...

journal_title：Life sciences

authors： Huang Z,Li W,Wang R,Zhang F,Chi Y,Wang D,Liu Z,Zhang Y,Matsuura E,Liu Q

更新日期：2010-11-20 00:00:00

abstract：:The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition ...

journal_title：Life sciences

authors： Nieoullon A,Kerkerian L,Dusticier N

更新日期：1982-04-05 00:00:00

abstract：:The effect of naloxone upon neurologic deficit was evaluated in a model of transient forebrain ischemia in rats. Awake male Wistar rats were subjected to a 30 minute ischemia by occluding both common carotid arteries 8 days after cauterizing vertebral arteries. Administration of naloxone 1 or 5 mg/kg iv 10 minutes aft...

journal_title：Life sciences

authors： Capdeville C,Pruneau D,Allix M,Plotkine M,Boulu RG

更新日期：1986-02-03 00:00:00

abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

journal_title：Life sciences

authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

更新日期：2001-08-17 00:00:00

abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...

journal_title：Life sciences

authors： Cuccheddu T,Floris S,Serra M,Porceddu ML,Sanna E,Biggio G

更新日期：1995-03-10 00:00:00

abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...

journal_title：Life sciences

authors： Rico EP,Senger MR,Fauth Mda G,Dias RD,Bogo MR,Bonan CD

更新日期：2003-09-05 00:00:00

abstract：:The effects of nicotine on normal physiological function are of increasing concern. Preliminary to studies on the effects of prenatal exposure to nicotine, we examined methods of administering nicotine to rats. Drinking water containing nicotine was not palatable to rats and was an unsatisfactory method in our hands, ...

journal_title：Life sciences

authors： Murrin LC,Ferrer JR,Zeng WY,Haley NJ

更新日期：1987-04-27 00:00:00

abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

journal_title：Life sciences

authors： Osadchii O,Woodiwiss A,Alves N,Norton G

更新日期：2005-12-12 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:The presence of gonadotropin-releasing hormone (GnRH) binding sites in biopsy samples of human epithelial ovarian cancer and ovarian tumor cell lines as well as the demonstration of the inhibitory effects of GnRH analogues on the growth of these cells raised the possibility that GnRH is produced locally by ovarian can...

journal_title：Life sciences

authors： Yin H,Cheng KW,Hwa HL,Peng C,Auersperg N,Leung PC

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output o...

journal_title：Life sciences

authors： Sánchez-Campos S,Tuñón MJ,González P,Marín JJ,González-Gallego J

更新日期：1998-01-01 00:00:00

abstract：:Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....

journal_title：Life sciences

authors： Elliott ME

更新日期：1990-01-01 00:00:00

abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

journal_title：Life sciences

authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

更新日期：2000-02-18 00:00:00

abstract：:Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...

journal_title：Life sciences

authors： Jourdan D,Ardid D,Chapuy E,Le Bars D,Eschalier A

更新日期：1998-01-01 00:00:00

abstract：:Polyamines have been shown to relax several types of smooth muscle including vasculature. In the estrogen-treated uterus, uterine blood flow and polyamine levels in the uterus are increased. The relaxant effect of polyamines on blood vessels suggest that polyamines may act on uterine vasculature to cause uterine hyper...

journal_title：Life sciences

authors： Wing LY

更新日期：1992-01-01 00:00:00

abstract：AIMS:TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of colorectal cancer keep largely unknown. Therefore, we sought to investigate the roles and the molecular mechanisms of TRAF6 in regulation colorectal cancer. MATER...

journal_title：Life sciences

authors： Zhu G,Cheng Z,Huang Y,Zheng W,Yang S,Lin C,Ye J

更新日期：2019-10-15 00:00:00

abstract：:Extracts of Chan Su, a traditional Chinese medication used as a topical anesthetic and cardiac medication, were incubated with cardiomyocytes that had been loaded with a calcium specific fluorescent probe. Calcium transients were measured by real-time fluorescence spectrophotometry following treatment. The transients ...

journal_title：Life sciences

authors： Bick RJ,Poindexter BJ,Sweney RR,Dasgupta A

更新日期：2002-12-27 00:00:00

abstract：AIMS:Chemo-resistance still was the main obstacle for AML patients, more effective and less toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug for diabetes recently delivered us a new identity that it exerted anti-tumor activity through suppressing mTOR in various tumors. But the a...

journal_title：Life sciences

authors： Yuan F,Cheng C,Xiao F,Liu H,Cao S,Zhou G

更新日期：2020-02-15 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:The role of serotonin (5-HT) in the regulation of steroidogenesis in the ovary via 5-HT2 receptor was studied in normal cycling rats and their preovulatory follicles. Oral administration of ketanserin (KET), a selective 5-HT2 antagonist, at 10 mg/kg BW at 1100h on the day of proestrus resulted in a marked decrease in ...

journal_title：Life sciences

authors： Tanaka E,Baba N,Toshida K,Suzuki K

更新日期：1993-01-01 00:00:00

abstract：:In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...

journal_title：Life sciences

authors： Fabbri E,Buzzi M,Biondi C,Capuzzo A

更新日期：1999-01-01 00:00:00

abstract：:Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...

journal_title：Life sciences

authors： Chinellato A,Froldi G,Caparrotta L,Ragazzi E

更新日期：1998-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effects of a mood stabilizer lamotrigine (LMG) on learning and memory processes using Morris water maze (MWM), modified elevated plus maze (mEPM) and passive avoidance (PA) tests. MAIN METHODS:Balb-c mice were used. LMG were injected (20; 40mg/kg, intraperitoneal, i.p....

journal_title：Life sciences

authors： Celikyurt IK,Ulak G,Mutlu O,Akar FY,Erden F,Komsuoglu SS

更新日期：2012-12-17 00:00:00

abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...

journal_title：Life sciences

authors： Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

更新日期：2020-10-15 00:00:00

abstract：:The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M +...

journal_title：Life sciences

authors： Ahmed MS,Randall LW,Sibai B,Dass C,Fridland G,Desiderio DM,Tolun E

更新日期：1987-05-25 00:00:00

abstract：:The conversion of beta-carotene to retinal and the succeeding metabolic process of the retinal leading to production of retinol and retinyl esters are the prerequisite for the utilization of beta-carotene as a provitamin A. These processes are participated by beta-carotene cleavage enzyme, retinal reductase and retino...

journal_title：Life sciences

authors： Tajima S,Goda T,Takase S

更新日期：1999-01-01 00:00:00