Abstract:
:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand in hand to support cancer cell progression. The important aspect in cancer and autophagy is the interdependence of autophagy in the survival and progression of cancer cells. Autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell types. Therefore, inhibition of autophagy as an effective therapeutic approach is being actively studied and tested in clinical studies. Multiple metabolic pathways are linked with autophagy that could potentially be a significant target for chemotherapeutic strategy. The comprehension of the interconnection of autophagy with cancer metabolism can pave a novel findings for effective combinatorial therapeutic strategies.
journal_name
Life Scijournal_title
Life sciencesauthors
Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar Ddoi
10.1016/j.lfs.2020.118184subject
Has Abstractpub_date
2020-10-15 00:00:00pages
118184eissn
0024-3205issn
1879-0631pii
S0024-3205(20)30936-Xjournal_volume
259pub_type
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