Molecular mechanisms of interplay between autophagy and metabolism in cancer.

Abstract:

:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand in hand to support cancer cell progression. The important aspect in cancer and autophagy is the interdependence of autophagy in the survival and progression of cancer cells. Autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell types. Therefore, inhibition of autophagy as an effective therapeutic approach is being actively studied and tested in clinical studies. Multiple metabolic pathways are linked with autophagy that could potentially be a significant target for chemotherapeutic strategy. The comprehension of the interconnection of autophagy with cancer metabolism can pave a novel findings for effective combinatorial therapeutic strategies.

journal_name

Life Sci

journal_title

Life sciences

authors

Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

doi

10.1016/j.lfs.2020.118184

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

118184

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)30936-X

journal_volume

259

pub_type

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