Abstract：
:The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition of 3H-glutamate uptake from rat striatal homogenates. No change occurred with samples from the frontal cortex. Dopaminergic inhibition of HAGU in striatal homogenates was shown to be reversed in the presence of haloperidol or domperidone which act by blocking dopaminergic receptor sites. These results are consistent with the existence of an inhibitory control of the neuronal activity of the glutamatergic neurons in the striatum by the nigro-striatal dopaminergic input. The effects could be due to the activation of D2-like DA receptors located at pre-synaptic levels on cortico-striatal glutamatergic nerve endings.
journal_name
Life Scijournal_title
Life sciencesauthors
Nieoullon A,Kerkerian L,Dusticier Ndoi
10.1016/0024-3205(82)90658-0subject
Has Abstractpub_date
1982-04-05 00:00:00pages
1165-72issue
14eissn
0024-3205issn
1879-0631pii
0024-3205(82)90658-0journal_volume
30pub_type
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