Abstract：
:The influence of the stage of the estrous cycle on binding of [3H]diazepam was examined in membranes from brains of female mice. In order to conserve endogenous factors such as progesterone, other steroids, or GABA, the assay was performed without the extensive washing procedures typically employed in measurements of benzodiazepine binding. Significant variations in the apparent maximal numbers of binding sites (Bmax) were noted during the estrous cycle in both hypothalamus and cortex. The Bmax measured in membranes from proestrus female mice was significantly higher than in membranes from mice at other stages in the estrous cycle. Variations in apparent equilibrium binding dissociation constants (Kd) were not statistically significant by stage of the estrous cycle. The demonstrated variations in binding suggest the existence of a factor which varies with the estrous cycle in female mice and modulates the activity of the GABAA receptor complex.
journal_name
Life Scijournal_title
Life sciencesauthors
Martin JV,Williams DBdoi
10.1016/0024-3205(95)02177-ksubject
Has Abstractpub_date
1995-01-01 00:00:00pages
1903-9issue
21eissn
0024-3205issn
1879-0631pii
002432059502177Kjournal_volume
57pub_type
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